Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms23020985
Keywords
COPD; innate immune system; inflammation; bronchial epithelium; macrophages; TLR; bacterial colonization
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Chronic obstructive pulmonary disease (COPD) is a common disease characterized by progressive airflow limitation due to chronic inflammation in the bronchi. The mechanisms of the innate immune system play a role in the pathogenesis of COPD, leading to chronic inflammation and lung tissue damage.
Chronic obstructive pulmonary disease (COPD) is a common, socially significant disease characterized by progressive airflow limitation due to chronic inflammation in the bronchi. Although the causes of COPD are considered to be known, the pathogenesis of the disease continues to be a relevant topic of study. Mechanisms of the innate immune system are involved in various links in the pathogenesis of COPD, leading to persistence of chronic inflammation in the bronchi, their bacterial colonization and disruption of lung structure and function. Bronchial epithelial cells, neutrophils, macrophages and other cells are involved in the development and progression of the disease, demonstrating multiple compromised immune mechanisms.
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