Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study

(2014) Chang-Fu Kuo et al.   ANNALS OF THE RHEUMATIC DISEASES

Evolutionary history and metabolic insights of ancient mammalian uricases

(2014) J. T. Kratzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9

(2014) Brian J DeBosch et al.   Nature Communications

Uric Acid - Key Ingredient in the Recipe for Cardiorenal Metabolic Syndrome

(2014) Kunal Chaudhary et al.   CardioRenal Medicine

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Uric acid, chronic kidney disease and type 2 diabetes: A cluster of vascular risk factors

(2013) Vasilios G. Athyros et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis

(2013) Arrigo F.G. Cicero et al.   JOURNAL OF HYPERTENSION

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Hyperuricemia Causes Pancreatic β-Cell Death and Dysfunction through NF-κB Signaling Pathway

(2013) Lu Jia et al.   PLoS One

The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality

(2013) David Gustafsson et al.   BMC Nephrology

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Uric Acid Induces Renal Inflammation via Activating Tubular NF-κB Signaling Pathway

(2012) Yang Zhou et al.   PLoS One

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced interleukin-1β production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals

(2012) Eleni E Mylona et al.   ARTHRITIS RESEARCH & THERAPY

Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008

(2011) Yanyan Zhu et al.   ARTHRITIS AND RHEUMATISM

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Gout

(2011) Tuhina Neogi   NEW ENGLAND JOURNAL OF MEDICINE

Gout. Epidemiology of gout

(2011) Edward Roddy et al.   ARTHRITIS RESEARCH & THERAPY

The Role of Uric Acid as an Endogenous Danger Signal in Immunity and Inflammation

(2011) Faranak Ghaemi-Oskouie et al.   Current Rheumatology Reports

How interleukin-1β induces gouty arthritis

(2010) Charles A. Dinarello   ARTHRITIS AND RHEUMATISM

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

The genetic basis of hyperuricaemia and gout

(2010) Tony R. Merriman et al.   JOINT BONE SPINE

Caught red-handed: uric acid is an agent of inflammation

(2010) Yan Shi   JOURNAL OF CLINICAL INVESTIGATION

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Uric acid and evolution

(2010) B. Alvarez-Lario et al.   RHEUMATOLOGY

Monosodium urate crystals in inflammation and immunity

(2009) Yan Shi et al.   IMMUNOLOGICAL REVIEWS

Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome

(2009) Ru Liu-Bryan   IMMUNOLOGY AND CELL BIOLOGY

Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1  by mononuclear cells through a caspase 1-mediated process

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