Rheumatoid arthritis CD14 + monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression

(2020) Xiu-Qiong Fu et al.   Cell Death & Disease

Alterations and abnormal expression of A20 in peripheral monocyte subtypes in patients with rheumatoid arthritis

(2020) Lu Zhang et al.   CLINICAL RHEUMATOLOGY

ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome

(2019) Xiwen Dong et al.   Cellular & Molecular Immunology

Preferences of Patients and At-risk Individuals for Preventive Approaches to Rheumatoid Arthritis

(2019) Marie Falahee et al.   CLINICAL THERAPEUTICS

The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion

(2019) Lewis C Rodgers et al.   RHEUMATOLOGY

Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation

(2018) Markus Zeisbrich et al.   ANNALS OF THE RHEUMATIC DISEASES

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses

(2018) Bo Ruem Yoon et al.   Frontiers in Immunology

Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis

(2018) Amit Kumar Rana et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Metabolic regulation of macrophage phenotype and function

(2017) Shilpi Saha et al.   IMMUNOLOGICAL REVIEWS

CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression

(2017) Yanxia Guo et al.   JOURNAL OF IMMUNOLOGY

The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2Production

(2017) Zbigniew Zasłona et al.   JOURNAL OF IMMUNOLOGY

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Preventing progression from arthralgia to arthritis: targeting the right patients

(2017) Hanna W. van Steenbergen et al.   Nature Reviews Rheumatology

STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells

(2017) Man Li et al.   Oncotarget

β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function

(2017) Leonie Schittenhelm et al.   Frontiers in Immunology

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

2016 update of the EULAR recommendations for the management of early arthritis

(2016) Bernard Combe et al.   ANNALS OF THE RHEUMATIC DISEASES

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

(2016) Zhen Yang et al.   Science Translational Medicine

Monocyte trafficking across the vessel wall

(2015) Teresa Gerhardt et al.   CARDIOVASCULAR RESEARCH

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical AtherosclerosisCLINICAL PERSPECTIVE

(2015) Lindsay M. Reynolds et al.   Circulation-Cardiovascular Genetics

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis

(2015) Annette E. Neele et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-Citrullinated Protein Antibodies Induce Macrophage Subset Disequilibrium in RA Patients

(2015) Wei Zhu et al.   INFLAMMATION

Surface APRIL Is Elevated on Myeloid Cells and Is Associated with Disease Activity in Patients with Rheumatoid Arthritis

(2015) A. J. Weldon et al.   JOURNAL OF RHEUMATOLOGY

The number of circulating monocytes as biomarkers of the clinical response to methotrexate in untreated patients with rheumatoid arthritis

(2015) Luis Chara et al.   Journal of Translational Medicine

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical AtherosclerosisCLINICAL PERSPECTIVE

(2015) Lindsay M. Reynolds et al.   Circulation-Cardiovascular Genetics

A Single-Cell Gene-Expression Profile Reveals Inter-Cellular Heterogeneity within Human Monocyte Subsets

(2015) Susanne T. Gren et al.   PLoS One

Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

(2014) Wei Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

(2014) M. A. Hoeksema et al.   EMBO Molecular Medicine

Functional Phenotype of Synovial Monocytes Modulating Inflammatory T-Cell Responses in Rheumatoid Arthritis (RA)

(2014) Bo Ruem Yoon et al.   PLoS One

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity

(2014) Ewa Klimek et al.   Biomed Research International

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced InflammationIn Vivo

(2013) João Antônio Chaves de Souza et al.   MEDIATORS OF INFLAMMATION

Circulating CD4+CD161+ T Lymphocytes Are Increased in Seropositive Arthralgia Patients but Decreased in Patients with Newly Diagnosed Rheumatoid Arthritis

(2013) Paulina Chalan et al.   PLoS One

EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis

(2012) Danielle M Gerlag et al.   ANNALS OF THE RHEUMATIC DISEASES

Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells

(2012) Ji Hyeon Ju et al.   ARTHRITIS AND RHEUMATISM

Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients

(2012) L. R. Coulthard et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

 -Enolase Expressed on the Surfaces of Monocytes and Macrophages Induces Robust Synovial Inflammation in Rheumatoid Arthritis

(2012) S. Bae et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis

(2011) Leonard C Harty et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis

(2011) Monika Biniecka et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

(2011) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: Findings of a prospective pilot study

(2011) Yoony Y. J. Gent et al.   ARTHRITIS AND RHEUMATISM

The CD14bright CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population

(2011) Manuela Rossol et al.   ARTHRITIS AND RHEUMATISM

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

(2011) T. Mori et al.   INTERNATIONAL IMMUNOLOGY

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia

(2010) L. A. van de Stadt et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies

(2009) D Sugiyama et al.   ANNALS OF THE RHEUMATIC DISEASES

Toll-like Receptor 9 Activation of Signal Transducer and Activator of Transcription 3 Constrains Its Agonist-Based Immunotherapy

(2009) M. Kortylewski et al.   CANCER RESEARCH

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

(2009) H. G. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA