Crosstalk Between Staphylococcus aureus and Innate Immunity: Focus on Immunometabolism

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

(2020) Kelsey J. Yamada et al.   PLoS Pathogens

Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation

(2020) Sebastián A. Riquelme et al.   Cell Metabolism

A reactive metabolite as an immune suppressant

(2020) Vijyendra Ramesh et al.   NATURE IMMUNOLOGY

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive Staphylococcus aureus infection

(2020) Aimee D. Potter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines

(2020) Nitija Tiwari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunometabolism during Mycobacterium tuberculosis Infection

(2020) Nicole C. Howard et al.   TRENDS IN MICROBIOLOGY

Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)

(2020) Lorena Tuchscherr et al.   Frontiers in Microbiology

Pulmonary Pathogens Adapt to Immune Signaling Metabolites in the Airway

(2020) Sebastián A. Riquelme et al.   Frontiers in Immunology

Metabolic Regulation of Myeloid-Derived Suppressor Cell Function in Cancer

(2020) Yufei Wang et al.   Cells

Sustained Coinfections with Staphylococcus aureus and Pseudomonas aeruginosa in Cystic Fibrosis

(2020) Anthony J Fischer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies

(2020) Katrin Schilcher et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genotypic and Phenotypic Diversity of Staphylococcus aureus Isolates from Cystic Fibrosis Patient Lung Infections and Their Interactions with Pseudomonas aeruginosa

(2020) Eryn E. Bernardy et al.   mBio

Resident macrophages acquire innate immune memory in staphylococcal skin infection

(2020) Reinhild Feuerstein et al.   eLife

Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection

(2020) Cortney E. Heim et al.   Nature Microbiology

The Role of HIF in Immunity and Inflammation

(2020) Anne F. McGettrick et al.   Cell Metabolism

Immunometabolism in the Single-Cell Era

(2020) Maxim N. Artyomov et al.   Cell Metabolism

Trained immunity and host‐pathogen interactions

(2020) Adeline Peignier et al.   CELLULAR MICROBIOLOGY

Staphylococcus aureus ATP Synthase Promotes Biofilm Persistence by Influencing Innate Immunity

(2020) Megan E. Bosch et al.   mBio

Consequences of Metabolic Interactions during Staphylococcus aureus Infection

(2020) Tania Wong Fok Lung et al.   Toxins

Systematic Reconstruction of the Complete Two-Component Sensorial Network in Staphylococcus aureus

(2020) B. Rapun-Araiz et al.   mSystems

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

Help, hinder, hide and harm: what can we learn from the interactions between Pseudomonas aeruginosa and Staphylococcus aureus during respiratory infections?

(2019) Dominique Hope Limoli et al.   THORAX

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

(2019) Nicholas A. Turner et al.   NATURE REVIEWS MICROBIOLOGY

Metabolic Adaptation in MRSA Pneumonia

(2019) Stanislaw J. Gabryszewski et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice

(2019) Taylor S. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Fatty acid transport protein 2 reprograms neutrophils in cancer

(2019) Filippo Veglia et al.   NATURE

Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent

(2019) McKenzie K. Lehman et al.   mBio

Central metabolic interactions of immune cells and microbes: prospects for defeating infections

(2019) Ana Traven et al.   EMBO REPORTS

Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs

(2019) Jérôme Mastio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

(2019) Dehong Yan et al.   Frontiers in Immunology

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Lactylation drives resolution

(2019) Erin R. Williams   Science Signaling

Staphylococcus aureus small colony variants impair host immunity by activating host cell glycolysis and inducing necroptosis

(2019) Tania Wong Fok Lung et al.   Nature Microbiology

Histone Lactylation: A New Role for Glucose Metabolism

(2019) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection

(2018) Kelsey J. Yamada et al.   INFECTION AND IMMUNITY

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

(2018) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

(2018) Taylor S. Cohen et al.   Cell Reports

Genetic requirements for Staphylococcus aureus nitric oxide resistance and virulence

(2018) Melinda R. Grosser et al.   PLoS Pathogens

Methicillin-resistant Staphylococcus aureus

(2018) Andie S. Lee et al.   Nature Reviews Disease Primers

Heterogeneity of Ly6G+Ly6C+ myeloid-derived suppressor cell (MDSC) infiltrates during S. aureus biofilm infection

(2018) Cortney E. Heim et al.   INFECTION AND IMMUNITY

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory

(2018) Liana C. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

(2018) Christopher M. Rice et al.   Nature Communications

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology

(2017) Antonio Sica et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection

(2017) Matthew Wickersham et al.   Cell Reports

Staphylococcus aureus pathogenesis in diverse host environments

(2017) Divya Balasubramanian et al.   Pathogens and Disease

Epigenetics and Trained Immunity

(2017) Charlotte D.C.C. van der Heijden et al.   ANTIOXIDANTS & REDOX SIGNALING

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

(2016) Harding H. Luan et al.   Cell Metabolism

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Diabetes and risk of community-acquiredStaphylococcus aureusbacteremia: a population-based case–control study

(2016) Jesper Smit et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage

(2016) Beáta Németh et al.   FASEB JOURNAL

Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus

(2016) Liana C. Chan et al.   INFECTION AND IMMUNITY

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Metabolic crosstalk between host and pathogen: sensing, adapting and competing

(2016) Andrew J. Olive et al.   NATURE REVIEWS MICROBIOLOGY

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

(2016) Xinfeng Chen et al.   Oxidative Medicine and Cellular Longevity

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling

(2016) Kipyegon Kitur et al.   Cell Reports

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

(2016) Ekta Lachmandas et al.   Nature Microbiology

Myeloid-derived suppressor cells inhibit T cell proliferation in human extranodal NK/T cell lymphoma: a novel prognostic indicator

(2015) Han Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-12 Promotes Myeloid-Derived Suppressor Cell Recruitment and Bacterial Persistence duringStaphylococcus aureusOrthopedic Implant Infection

(2015) Cortney E. Heim et al.   JOURNAL OF IMMUNOLOGY

Long-term in vitro and in vivo effects of γ-irradiated BCG on innate and adaptive immunity

(2015) Rob J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-10 production by myeloid-derived suppressor cells contributes to bacterial persistence during Staphylococcus aureus orthopedic biofilm infection

(2015) Cortney E. Heim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection

(2015) Aimee D. Wilde et al.   PLoS Pathogens

Cutaneous Innate Immune Sensing of Toll-like Receptor 2-6 Ligands Suppresses T Cell Immunity by Inducing Myeloid-Derived Suppressor Cells

(2014) Yuliya Skabytska et al.   IMMUNITY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-Derived Suppressor Cells Contribute to Staphylococcus aureus Orthopedic Biofilm Infection

(2014) C. E. Heim et al.   JOURNAL OF IMMUNOLOGY

A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression duringStaphylococcus aureusInfection

(2014) Christina Tebartz et al.   JOURNAL OF IMMUNOLOGY

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Metabolic sensor governing bacterial virulence inStaphylococcus aureus

(2014) Yue Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Staphylococcus aureus small colony variants show common metabolic features in central metabolism irrespective of the underlying auxotrophism

(2014) André Kriegeskorte et al.   Frontiers in Cellular and Infection Microbiology

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Functional Modularity of the Arginine Catabolic Mobile Element Contributes to the Success of USA300 Methicillin-Resistant Staphylococcus aureus

(2013) Lance R. Thurlow et al.   Cell Host & Microbe

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Catabolite Control Protein E (CcpE) Is a LysR-type Transcriptional Regulator of Tricarboxylic Acid Cycle Activity inStaphylococcus aureus

(2013) Torsten Hartmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

The Staphylococcus aureus SrrAB Two-Component System Promotes Resistance to Nitrosative Stress and Hypoxia

(2013) T. L. Kinkel et al.   mBio

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

MyD88-Dependent Signaling Influences Fibrosis and Alternative Macrophage Activation during Staphylococcus aureus Biofilm Infection

(2012) Mark L. Hanke et al.   PLoS One

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Staphylococcus aureus Biofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo

(2011) L. R. Thurlow et al.   JOURNAL OF IMMUNOLOGY

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

(2010) B. A. Lipsky et al.   DIABETOLOGIA

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Metabolic Shifts in Immunity and Inflammation

(2010) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties

(2010) Sven Brandau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus

(2010) Martin Pagels et al.   MOLECULAR MICROBIOLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus

(2009) Kati Seidl et al.   BMC MICROBIOLOGY

Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1  in Long-Lived Mclk1+/- Mouse Mutants

(2009) D. Wang et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

(2009) R. Munoz-Planillo et al.   JOURNAL OF IMMUNOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

At the Crossroads of Bacterial Metabolism and Virulence Factor Synthesis in Staphylococci

(2009) G. A. Somerville et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

The phagocytes: neutrophils and monocytes

(2008) D. C. Dale et al.   BLOOD

Staphylococcus aureus CcpA Affects Biofilm Formation

(2008) K. Seidl et al.   INFECTION AND IMMUNITY

The Proinflammatory Cytokine-Induced IRG1 Protein Associates with Mitochondria

(2008) Daniel Degrandi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

(2008) Boris Görke et al.   NATURE REVIEWS MICROBIOLOGY

A Nitric Oxide-Inducible Lactate Dehydrogenase Enables Staphylococcus aureus to Resist Innate Immunity

(2008) A. R. Richardson et al.   SCIENCE