Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway

(2020) Tong An et al.   FEBS Journal

Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis

(2019) Zhiqiang Liu et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

(2019) Xin Zhou et al.   Cell Reports

Hippo Pathway in Mammalian Adaptive Immune System

(2019) Takayoshi Yamauchi et al.   Cells

YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11

(2019) Jing Wang et al.   MOLECULAR MEDICINE

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

(2019) Michael G. Dorrington et al.   Frontiers in Immunology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Participation of the IKK-α/β complex in the inhibition of the TNF-α/NF-κB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes

(2018) Erika Contreras-Nuñez et al.   BIOMEDICINE & PHARMACOTHERAPY

TLR3 Mediates Repair and Regeneration of Damaged Neonatal Heart through Glycolysis Dependent YAP1 Regulated miR-152 Expression

(2018) Xiaohui Wang et al.   CELL DEATH AND DIFFERENTIATION

GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis

(2018) Punithavathi Ranganathan et al.   JOURNAL OF IMMUNOLOGY

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

(2018) Mohammad Harun-Or-Rashid et al.   Journal of Neuroinflammation

Enhanced Glycolytic Metabolism Contributes to Cardiac Dysfunction in Polymicrobial Sepsis

(2017) Zhibo Zheng et al.   JOURNAL OF INFECTIOUS DISEASES

TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration

(2017) Y Gao et al.   Oncogenesis

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

(2017) Kathrin Renner et al.   Frontiers in Immunology

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila

(2016) Bo Liu et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma

(2016) S Murakami et al.   ONCOGENE

Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming

(2016) Silvia Selleri et al.   Oncotarget

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

(2016) Agustina Errea et al.   PLoS One

Lactic acid delays the inflammatory response of human monocytes

(2015) Katrin Peter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

(2015) Carsten Gram Hansen et al.   CELL RESEARCH

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

(2015) Cecilie Morland et al.   JOURNAL OF NEUROSCIENCE RESEARCH

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

MicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6

(2014) Xiaohui Wang et al.   CARDIOVASCULAR RESEARCH

Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

(2014) Zhe Shen et al.   CNS Neuroscience & Therapeutics

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

G protein-coupled receptors and the regulation of autophagy

(2014) Eric M. Wauson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cardiomyocyte-specific p65 NF-κB deletion protects the injured heart by preservation of calcium handling

(2013) Xiu Q. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NF-κB Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense

(2013) Hui Li et al.   MEDIATORS OF INFLAMMATION

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Nuclear NF- B p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer

(2009) P. Arun et al.   CLINICAL CANCER RESEARCH

Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock*

(2009) Mark E. Mikkelsen et al.   CRITICAL CARE MEDICINE

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Novel Tight-Binding Inhibitory Factor- B Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo Model of Airway Inflammation

(2009) C. D. Sommers et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology