Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

(2018) Rob J.W. Arts et al.   Cell Host & Microbe

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of AtherosclerosisNovelty and Significance

(2018) Jenneke Leentjens et al.   CIRCULATION RESEARCH

Nonspecific immunomodulators for recurrent respiratory tract infections, wheezing and asthma in children

(2018) Susanna Esposito et al.   Current Opinion in Allergy and Clinical Immunology

Trained immunity as a novel therapeutic strategy

(2018) Vera P Mourits et al.   CURRENT OPINION IN PHARMACOLOGY

What if protective immunity is antigen-driven and not due to so-called “memory” B and T cells?

(2018) Rolf M. Zinkernagel   IMMUNOLOGICAL REVIEWS

Innate immune memory: An evolutionary perspective

(2018) Benjamin Gourbal et al.   IMMUNOLOGICAL REVIEWS

How Inflammasomes Inform Adaptive Immunity

(2018) Charles L. Evavold et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-specific effects of vaccines: Current evidence and potential implications

(2018) Charlotte L.C.J. de Bree et al.   SEMINARS IN IMMUNOLOGY

Non-specific Effect of Vaccines: Immediate Protection against Respiratory Syncytial Virus Infection by a Live Attenuated Influenza Vaccine

(2018) Young J. Lee et al.   Frontiers in Microbiology

Bacillus Calmette–Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice

(2018) Charlotte L. C. J. de Bree et al.   Frontiers in Immunology

The Elusive Anti-Candida Vaccine: Lessons From the Past and Opportunities for the Future

(2018) Gloria Hoi Wan Tso et al.   Frontiers in Immunology

Novel Platforms for the Development of a Universal Influenza Vaccine

(2018) Arun Kumar et al.   Frontiers in Immunology

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders

(2018) Rob J. W. Arts et al.   Frontiers in Immunology

Adjuvant Effect of Bacille Calmette–Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn

(2018) Annette Scheid et al.   Frontiers in Immunology

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Mevalonate Metabolism in Cancer Stemness and Trained Immunity

(2018) Georg Gruenbacher et al.   Frontiers in Oncology

Induction of innate immune memory: the role of cellular metabolism

(2018) Jorge Domínguez-Andrés et al.   CURRENT OPINION IN IMMUNOLOGY

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases

(2017) Renate M Hoogeveen et al.   EUROPEAN HEART JOURNAL

The use of databases, data mining and immunoinformatics in vaccinology: where are we?

(2017) Nagendra R. Hegde et al.   Expert Opinion on Drug Discovery

Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

(2017) Michael E. Pichichero   Expert Review of Vaccines

Blood monocytes sample MelanA/MART1 antigen for long-lasting cross-presentation to CD8+ T cells after differentiation into dendritic cells

(2017) Florence Faure et al.   INTERNATIONAL JOURNAL OF CANCER

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

(2017) David J. Dowling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In silico design of knowledge-based Plasmodium falciparum epitope ensemble vaccines

(2017) Shymaa Abdullah Damfo et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Broncho Vaxom (OM-85) modulates rhinovirus docking proteins on human airway epithelial cells via Erk1/2 mitogen activated protein kinase and cAMP

(2017) Michael Roth et al.   PLoS One

Preconditioning with Lipopolysaccharide or Lipoteichoic Acid Protects against Staphylococcus aureus Mammary Infection in Mice

(2017) Koen Breyne et al.   Frontiers in Immunology

Effects of Bacillus Calmette-Guérin (BCG) vaccination at birth on T and B lymphocyte subsets: Results from a clinical randomized trial

(2017) Nina Marie Birk et al.   Scientific Reports

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

(2016) Boris Novakovic et al.   CELL

Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses

(2016) Katrin D Mayer-Barber et al.   Cellular & Molecular Immunology

Infection in an aging population

(2016) Kimberly A Kline et al.   CURRENT OPINION IN MICROBIOLOGY

New Biological Insights in the Immunomodulatory Effects of Mucosal Polybacterial Vaccines in Clinical Practice

(2016) Marta Tejera-Alhambra et al.   CURRENT PHARMACEUTICAL DESIGN

Innate immune memory: Implications for host responses to damage-associated molecular patterns

(2016) Tania O. Crișan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host withSaccharomyces cerevisiae

(2016) Lisa Rizzetto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MV140, a sublingual polyvalent bacterial preparation to treat recurrent urinary tract infections, licenses human dendritic cells for generating Th1, Th17 and IL-10 responses via Syk and MyD88

(2016) C Benito-Villalvilla et al.   Mucosal Immunology

Nonspecific effect of BCG vaccination at birth on early childhood infections: a randomized, clinical multicenter trial

(2016) Jesper Kjærgaard et al.   PEDIATRIC RESEARCH

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Unravelling the nature of non-specific effects of vaccines—A challenge for innate immunologists

(2016) Kristoffer Jarlov Jensen et al.   SEMINARS IN IMMUNOLOGY

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection

(2016) Ulrike Schleicher et al.   Cell Reports

Immunometabolic Pathways in BCG-Induced Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Reports

Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines

(2015) Bastiaan A. Blok et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Comparison of sublingual therapeutic vaccine with antibiotics for the prophylaxis of recurrent urinary tract infections

(2015) María F. Lorenzo-Gómez et al.   Frontiers in Cellular and Infection Microbiology

Extending the Clinical Horizons of Mucosal Bacterial Vaccines: Current Evidence and Future Prospects

(2014) Silvia Sanchez-Ramon et al.   CURRENT DRUG TARGETS

Innate immune memory: towards a better understanding of host defense mechanisms

(2014) Jessica Quintin et al.   CURRENT OPINION IN IMMUNOLOGY

Immunological memory within the innate immune system

(2014) J. C. Sun et al.   EMBO JOURNAL

Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations

(2014) Kirsten M. Kloepfer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection

(2014) Sandra Ribes et al.   Journal of Neuroinflammation

The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study

(2014) Jenneke Leentjens et al.   PLoS One

Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

(2014) B. Zhang et al.   SCIENCE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Antibiotics for treatment and prevention of exacerbations of chronic obstructive pulmonary disease

(2013) Robert Wilson et al.   JOURNAL OF INFECTION

Acute sinusitis in children: Do antibiotics have any role?

(2013) Mark J. Abzug   JOURNAL OF INFECTION

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

(2013) Johanneke Kleinnijenhuis et al.   Journal of Innate Immunity

Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo

(2013) Mohlopheni J. Marakalala et al.   MICROBES AND INFECTION

A small jab – a big effect: nonspecific immunomodulation by vaccines

(2013) Christine S. Benn et al.   TRENDS IN IMMUNOLOGY

On HIV diversity

(2012) Thumbi Ndung’u et al.   AIDS

Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: Current understanding and perspectives on engineered BCG vaccine

(2012) Koji Kawai et al.   CANCER SCIENCE

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Evaluation of a therapeutic vaccine for the prevention of recurrent urinary tract infections versus prophylactic treatment with antibiotics

(2012) M. F. Lorenzo-Gómez et al.   INTERNATIONAL UROGYNECOLOGY JOURNAL

Epidemic Pertussis in 2012 — The Resurgence of a Vaccine-Preventable Disease

(2012) James D. Cherry   NEW ENGLAND JOURNAL OF MEDICINE

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Louis Pasteur, the Father of Immunology?

(2012) Kendall A. Smith   Frontiers in Immunology

Detection of functional antigen-specific T cells from urine of non-muscle invasive bladder cancer patients

(2012) Claire Pieraerts et al.   OncoImmunology

FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice

(2011) Mohamed F. Abdul-Careem et al.   ANTIVIRAL RESEARCH

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Sublingual therapeutic immunization with a polyvalent bacterial preparation in patients with recurrent respiratory infections: immunomodulatory effect on antigen-specific memory CD4+ T cells and impact on clinical outcome

(2011) D. Alecsandru et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?

(2011) Peter Aaby et al.   JOURNAL OF INFECTIOUS DISEASES

Persistence of Circulating Memory B Cell Clones with Potential for Dengue Virus Disease Enhancement for Decades following Infection

(2011) S. A. Smith et al.   JOURNAL OF VIROLOGY

Thy1+ Nk Cells from Vaccinia Virus-Primed Mice Confer Protection against Vaccinia Virus Challenge in the Absence of Adaptive Lymphocytes

(2011) Geoffrey O. Gillard et al.   PLoS Pathogens

CpG oligodeoxynucleotides protect against the 2009 H1N1 pandemic influenza virus infection in a murine model

(2010) Tao Jiang et al.   ANTIVIRAL RESEARCH

Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection

(2010) N. Munoz et al.   INFECTION AND IMMUNITY

The bacterial extract OM-85 BV protects mice against Influenza and Salmonella infection

(2010) Wolfgang G. Bessler et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The immunostimulant OM-85 BV prevents wheezing attacks in preschool children

(2010) Cem Hasan Razi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of Whole‐Cell Killed Bacterial Vaccines in Preventing Pneumonia and Death during the 1918 Influenza Pandemic

(2010) Yu‐Wen Chien et al.   JOURNAL OF INFECTIOUS DISEASES

Prophylactic Administration of Bacterially Derived Immunomodulators Improves the Outcome of Influenza Virus Infection in a Murine Model

(2010) E. B. Norton et al.   JOURNAL OF VIROLOGY

The epidemiology of urinary tract infection

(2010) Betsy Foxman   Nature Reviews Urology

Clonal dissection of the human memory B-cell repertoire following infection and vaccination

(2009) Debora Pinna et al.   EUROPEAN JOURNAL OF IMMUNOLOGY