S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

A chemoproteomic portrait of the oncometabolite fumarate

(2019) Rhushikesh A. Kulkarni et al.   Nature Chemical Biology

Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid

(2018) Yosuke Isobe et al.   ACS Chemical Biology

Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target

(2018) Jessica L. Counihan et al.   ACS Chemical Biology

A Dimethyl-Labeling-Based Strategy for Site-Specifically Quantitative Chemical Proteomics

(2018) Fan Yang et al.   ANALYTICAL CHEMISTRY

Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling

(2018) Wei Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe

(2018) Ying Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

(2018) He Huang et al.   MOLECULAR CELL

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

(2018) Christian S. Lentz et al.   Nature Chemical Biology

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker

(2018) Ke Qin et al.   ACS Chemical Biology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Chemical proteomics reveals new targets of cysteine sulfinic acid reductase

(2018) Salma Akter et al.   Nature Chemical Biology

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus

(2018) Junsheng Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

(2018) Michael J. Bollong et al.   NATURE

Diverse Redoxome Reactivity Profiles of Carbon Nucleophiles

(2017) Vinayak Gupta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective in vivo metabolic cell-labeling-mediated cancer targeting

(2017) Hua Wang et al.   Nature Chemical Biology

Global profiling of lysine reactivity and ligandability in the human proteome

(2017) Stephan M. Hacker et al.   Nature Chemistry

Quantitative time-resolved chemoproteomics reveals that stableO-GlcNAc regulates box C/D snoRNP biogenesis

(2017) Wei Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Proteome-wide covalent ligand discovery in native biological systems

(2016) Keriann M. Backus et al.   NATURE

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Quantitative Chemoproteomics for Site-Specific Analysis of Protein Alkylation by 4-Hydroxy-2-Nonenal in Cells

(2015) Jing Yang et al.   ANALYTICAL CHEMISTRY

Proteome-Wide Profiling of Targets of Cysteine reactive Small Molecules by Using Ethynyl Benziodoxolone Reagents

(2015) Daniel Abegg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Investigating the Proteome Reactivity and Selectivity of Aryl Halides

(2014) D. Alexander Shannon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial itaconate degradation promotes pathogenicity

(2014) Jahminy Sasikaran et al.   Nature Chemical Biology

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

pLogo: a probabilistic approach to visualizing sequence motifs

(2013) Joseph P O'Shea et al.   NATURE METHODS

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkylating Tryptic Peptides to Enhance Electrospray Ionization Mass Spectrometry Analysis

(2010) Suzanne E. Kulevich et al.   ANALYTICAL CHEMISTRY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Disparate proteome reactivity profiles of carbon electrophiles

(2008) Eranthie Weerapana et al.   Nature Chemical Biology