Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

(2022) Hai Wang et al.   Cell Metabolism

Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

(2022) Seok-Jo Kim et al.   iScience

Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux

(2022) Qingqing Hong et al.   BIOMEDICINE & PHARMACOTHERAPY

PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation

(2021) Takashi Shimizu et al.   Science Signaling

Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism

(2021) Shijiao Huang et al.   Frontiers in Cell and Developmental Biology

Aortic Aneurysms, Chronic Kidney Disease and Metalloproteinases

(2021) Michele Andreucci et al.   Biomolecules

A molecular single-cell lung atlas of lethal COVID-19

(2021) Johannes C. Melms et al.   NATURE

Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways

(2021) Dong Ni et al.   Frontiers in Immunology

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

(2021) Hongtu Cui et al.   EUROPEAN HEART JOURNAL

Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice

(2021) Hao Kan et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Emerging roles of Dectin-1 in noninfectious settings and in the CNS

(2021) M. Elizabeth Deerhake et al.   TRENDS IN IMMUNOLOGY

Atractylodin Attenuates Dextran Sulfate Sodium-Induced Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting Inflammatory Response Through the MAPK Pathway

(2021) Linghang Qu et al.   Frontiers in Pharmacology

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

(2021) Ying Shao et al.   Frontiers in Immunology

Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators

(2021) Ming Liu et al.   Frontiers in Cardiovascular Medicine

Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence

(2021) Ulises Ahumada-Castro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impact of intracellular innate immune receptors on immunometabolism

(2021) Wei-Chun Chou et al.   Cellular & Molecular Immunology

Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy

(2021) Fang Dong et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway

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Deep learning enables genetic analysis of the human thoracic aorta

(2021) James P. Pirruccello et al.   NATURE GENETICS

Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD

(2021) Charles I. V. Drummer et al.   Journal of Immunology Research

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

(2021) Shan Jiang et al.   Redox Biology

Novel Knowledge-Based Transcriptomic Profiling of Lipid Lysophosphatidylinositol-Induced Endothelial Cell Activation

(2021) Keman Xu et al.   Frontiers in Cardiovascular Medicine

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

(2020) Xiuli Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trimethylamine N‐oxide promotes apoE −/− mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

(2020) Peng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity

(2020) Yasuhiro Onogi et al.   Scientific Reports

Trained Immunity: An Underlying Driver of Inflammatory Atherosclerosis

(2020) Chao Zhong et al.   Frontiers in Immunology

End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression

(2020) Ruijing Zhang et al.   Redox Biology

Transcriptional and Cellular Diversity of the Human Heart

(2020) Nathan R. Tucker et al.   CIRCULATION

Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells

(2020) Francesco Ciscato et al.   EMBO REPORTS

Cytokine-like Roles for Metabolites in Immunity

(2020) Zbigniew Zasłona et al.   MOLECULAR CELL

Beta-glucans in advanced CKD: role in endotoxaemia and inflammation

(2020) Jonathan Wong et al.   BMC Nephrology

J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan

(2020) Naoki Nakagawa et al.   Scientific Reports

ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila

(2020) Sebastian Sorge et al.   Cell Reports

Vascular Endothelial Cells and Innate Immunity

(2020) Ying Shao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanism of succinate efflux upon reperfusion of the ischemic heart

(2020) Hiran A Prag et al.   CARDIOVASCULAR RESEARCH

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury

(2020) Jun-Jae Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

(2020) Jianjun Qi et al.   Cell Death & Disease

p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis

(2020) Solhee Noh et al.   Scientific Reports

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

(2020) Manoj Govindarajulu et al.   Frontiers in Molecular Neuroscience

Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators

(2020) Ming Liu et al.   Frontiers in Immunology

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes

(2020) Yu Sun et al.   Redox Biology

Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

(2020) Sanaz Dastghaib et al.   Cells

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

(2020) Alexander M. Fagenson et al.   Pathogens

Trained Immunity and Reactivity of Macrophages and Endothelial Cells

(2020) Charles Drummer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trimethylamine N-Oxide and Cardiovascular Outcomes in Patients with End-stage Kidney Disease Receiving Maintenance Hemodialysis

(2019) Jason R. Stubbs et al.   Clinical Journal of the American Society of Nephrology

Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells

(2019) Lucia Schnack et al.   Frontiers in Immunology

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction

(2019) Gurinder Bir Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein intake and amino acid supplementation regulates exercise recovery and performance through the modulation of mTOR, AMPK, FGF21 and immunity

(2019) Iván Torre-Villalvazo et al.   NUTRITION RESEARCH

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes

(2019) Eleftheria Ieronymaki et al.   Frontiers in Immunology

Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs

(2019) Yifan Lu et al.   Redox Biology

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Ly6C + Inflammatory Monocyte Differentiation Partially Mediates Hyperhomocysteinemia-Induced Vascular Dysfunction in Type 2 Diabetic db/db Mice

(2019) Pu Fang (方璞) et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Microbial Metabolite Trimethylamine N-Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis

(2019) Marion M. Chan et al.   Nutrients

Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease

(2019) Carmen Roncal et al.   Scientific Reports

Elevation of Trimethylamine-N-Oxide in Chronic Kidney Disease: Contribution of Decreased Glomerular Filtration Rate

(2019) Caroline C. Pelletier et al.   Toxins

Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors

(2019) Bin Lai et al.   Frontiers in Immunology

Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells

(2019) Xinyuan Li et al.   Redox Biology

Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury

(2018) Ying Shao et al.   ANTIOXIDANTS & REDOX SIGNALING

IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14)Highlights

(2018) Xinyuan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation

(2018) Xinyuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function

(2018) Lucie Hénaut et al.   Toxins

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

(2018) Huihong Zeng et al.   Frontiers in Physiology

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

(2018) Manuel Janeiro et al.   Nutrients

Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

(2018) Martina Rudnicki et al.   eLife

Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - A novel concept

(2018) Gayani K. Nanayakkara et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure

(2017) Ellen Winckelmans et al.   Environmental Health

Endothelial cell markers from clinician's perspective

(2017) Jelena Rakocevic et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells

(2017) Marijana Aradjanski et al.   HUMAN MOLECULAR GENETICS

The role of succinate and ROS in reperfusion injury – A critical appraisal

(2017) Tatyana N. Andrienko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury

(2017) Tanusree Sen et al.   JOURNAL OF NEUROSCIENCE

The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease

(2017) James A.P. Tomlinson et al.   KIDNEY INTERNATIONAL

Perilipins: a diversity of intracellular lipid droplet proteins

(2017) Hiroyuki Itabe et al.   Lipids in Health and Disease

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation

(2017) Martina B. Lorey et al.   MOLECULAR & CELLULAR PROTEOMICS

The immunology of atherosclerosis

(2017) Anton Gisterå et al.   Nature Reviews Nephrology

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise

(2017) Adeel Safdar et al.   Cold Spring Harbor Perspectives in Medicine

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell ActivationHighlights

(2016) Xinyuan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

(2016) Siroon Bekkering et al.   ATHEROSCLEROSIS

CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1α and PERK

(2016) Daisuke Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Lysophospholipids and their G protein-coupled receptors in atherosclerosis

(2016) Rong-Shan Li   Frontiers in Bioscience-Landmark

Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway

(2016) Jietang Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease

(2016) Anthony Virtue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of gut microbiota in atherosclerosis

(2016) Annika Lindskog Jonsson et al.   Nature Reviews Cardiology

Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets—“Sand Out and Gold Stays”

(2016) Ying Shao et al.   Journal of Cardiovascular Translational Research

Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

(2016) Xin Wang et al.   Journal of Cardiovascular Translational Research

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chronic kidney disease alters vascular smooth muscle cell phenotype

(2015) M Alexandra Monroy   Frontiers in Bioscience-Landmark

Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway

(2015) Xiaojin Sha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

(2015) Z Liu et al.   Cell Death & Disease

Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease

(2015) Shunsaku Nakagawa et al.   PLoS One

Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients

(2015) Xin Hai et al.   PLoS One

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hyperhomocysteinemia Potentiates Hyperglycemia-Induced Inflammatory Monocyte Differentiation and Atherosclerosis

(2014) P. Fang et al.   DIABETES

Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function

(2014) Ying Shao et al.   Journal of Hematology & Oncology

Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

(2014) Yanyan Yang et al.   MEDIATORS OF INFLAMMATION

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Alloantibody and Complement Promote T Cell–Mediated Cardiac Allograft Vasculopathy Through Noncanonical Nuclear Factor-κB Signaling in Endothelial Cells

(2013) Dan Jane-wit et al.   CIRCULATION

Inflammasomes: sensors of metabolic stresses for vascular inflammation 

(2013) Xiao-feng Yang   Frontiers in Bioscience-Landmark

An evolving new paradigm: endothelial cells – conditional innate immune cells

(2013) Jietang Mai et al.   Journal of Hematology & Oncology

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Severe Hyperhomocysteinemia Promotes Bone Marrow–Derived and Resident Inflammatory Monocyte Differentiation and Atherosclerosis in LDLr/CBS-Deficient Mice

(2012) Daqing Zhang et al.   CIRCULATION RESEARCH

PTEN-mediated akt/β-Catenin/foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury

(2012) Naoko Kamo et al.   HEPATOLOGY

Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle

(2012) R. M. Murphy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Intracellular Eukaryotic Parasites Have a Distinct Unfolded Protein Response

(2011) Sara J. C. Gosline et al.   PLoS One

Hypothalamic Responses to Fasting Indicate Metabolic Reprogramming Away from Glycolysis Toward Lipid Oxidation

(2010) Michal M. Poplawski et al.   ENDOCRINOLOGY

The Role of the Transcription Factor CREB in Immune Function

(2010) A. Y. Wen et al.   JOURNAL OF IMMUNOLOGY

Hyperhomocysteinemia Promotes Inflammatory Monocyte Generation and Accelerates Atherosclerosis in Transgenic Cystathionine β-Synthase–Deficient Mice

(2009) Daqing Zhang et al.   CIRCULATION

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY