DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury

(2018) Ying Shao et al.   ANTIOXIDANTS & REDOX SIGNALING

IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14)Highlights

(2018) Xinyuan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Uremic toxins are conditional danger- or homeostasis-associated molecular patterns

(2018) Rongshan Li   Frontiers in Bioscience-Landmark

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg

(2018) Keman Xu et al.   Frontiers in Immunology

FOXO transcription factors at the interface of metabolism and cancer

(2017) Wolfgang Link et al.   INTERNATIONAL JOURNAL OF CANCER

Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis

(2017) Shosuke Kawanishi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

(2017) Ya-feng Li et al.   Journal of Hematology & Oncology

A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

(2017) Luqiao Wang et al.   Journal of Hematology & Oncology

Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study

(2017) Hangfei Fu et al.   Journal of Hematology & Oncology

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetics and Oxidative Stress in Aging

(2017) Amy Guillaumet-Adkins et al.   Oxidative Medicine and Cellular Longevity

Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in space

(2017) Tao Lu et al.   PLoS One

Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract

(2017) Evagelia Spanou et al.   Frontiers in Genetics

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

(2017) Y. Yin et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

IL-35, as a newly proposed homeostasis-associated molecular pattern, plays three major functions including anti-inflammatory initiator, effector, and blocker in cardiovascular diseases

(2017) Xinyuan Li et al.   CYTOKINE

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell ActivationHighlights

(2016) Xinyuan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial CellsNovelty and Significance

(2016) Hang Xi et al.   CIRCULATION RESEARCH

Metabolic control of methylation and acetylation

(2016) Xiaoyang Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Alarming consequences – autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1

(2016) Dirk Holzinger et al.   CURRENT OPINION IN RHEUMATOLOGY

CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels

(2016) Karolina Szczepanowska et al.   EMBO JOURNAL

Mechanistic roles of autophagy in hematopoietic differentiation

(2016) Thomas Riffelmacher et al.   FEBS Journal

Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair

(2016) Cong-xin Huang   Frontiers in Bioscience-Landmark

Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration

(2016) Chan Chung et al.   HUMAN MOLECULAR GENETICS

Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway

(2016) Jietang Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system

(2016) Gian-Luca McLelland et al.   JOURNAL OF CELL BIOLOGY

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

(2016) Luqiao Wang et al.   Journal of Hematology & Oncology

Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery

(2016) Lucas M. Ferrer et al.   Journal of Cardiovascular Translational Research

Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

(2016) Xin Wang et al.   Journal of Cardiovascular Translational Research

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Muscle gets stressed? p53 represses and protects

(2015) L Latella et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway

(2015) Xiaojin Sha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Disruption of cellular homeostasis induces organelle stress and triggers apoptosis like cell-death pathways in malaria parasite

(2015) S Rathore et al.   Cell Death & Disease

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer Risk in Patients with Manifest Vascular Disease: Effects of Smoking, Obesity, and Metabolic Syndrome

(2013) R. C. M. van Kruijsdijk et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Inflammasomes: sensors of metabolic stresses for vascular inflammation 

(2013) Xiao-feng Yang   Frontiers in Bioscience-Landmark

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

IL-35 Is a Novel Responsive Anti-inflammatory Cytokine — A New System of Categorizing Anti-inflammatory Cytokines

(2012) Xinyuan Li et al.   PLoS One

S100A8 and S100A9 in Cardiovascular Biology and Disease

(2011) Michelle M. Averill et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

(2011) Cedric Blanpain et al.   Cell Stem Cell

DNA damage response in adult stem cells: pathways and consequences

(2011) Pankaj K. Mandal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of homocysteine metabolism and methylation in human and mouse tissues

(2010) Natalie C. Chen et al.   FASEB JOURNAL

Caspase-1 recognizes extended cleavage sites in its natural substrates

(2009) Jerry Shen et al.   ATHEROSCLEROSIS