PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation

MicroRNA-124 Reduces Arsenic-induced Endoplasmic Reticulum Stress and Neurotoxicity and is Linked with Neurodevelopment in Children

(2020) Hae-Ryung Park et al.   Scientific Reports

PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure

(2020) Takashi Shimizu et al.   iScience

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis

(2019) Eduardo Balsa et al.   MOLECULAR CELL

Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis

(2019) Ronald A. Panganiban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes

(2018) L. Montibeller et al.   CELL STRESS & CHAPERONES

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension

(2018) Abdul Q. Sheikh et al.   Cell Reports

Myostatin / miR-124-3p / GR signaling pathway regulates intramuscular fat deposition in mice

(2018) Kaiqing Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

STAT1 modulates tissue wasting or overgrowth downstream from PDGFRβ

(2017) Chaoyong He et al.   GENES & DEVELOPMENT

Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress-associated gene expression in retinal pigment epithelial cells

(2017) Xintong Jiang et al.   Molecular Medicine Reports

Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation

(2017) Li-Jia Bu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

(2017) Philip Kranz et al.   Cell Death & Disease

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target SlugCLINICAL PERSPECTIVE

(2016) Rachel K. Hopper et al.   CIRCULATION

BMP signaling in vascular biology and dysfunction

(2016) Amaya García de Vinuesa et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities

(2016) Sonia Y. Velásquez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer

(2016) Romana Moench et al.   Oncotarget

BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis

(2016) Jonathan D W Evans et al.   Lancet Respiratory Medicine

Genotype-Phenotype Effects of Bmpr2 Mutations on Disease Severity in Mouse Models of Pulmonary Hypertension

(2016) Andrea L. Frump et al.   Pulmonary Circulation

Mechanism of Action of Trazodone: a Multifunctional Drug

(2016) Stephen M. Stahl   CNS SPECTRUMS

Metabolic Dysfunction in Pulmonary Arterial Hypertension

(2015) Tufik R. Assad et al.   CURRENT HYPERTENSION REPORTS

Genetic counselling in a national referral centre for pulmonary hypertension

(2015) Barbara Girerd et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects

(2015) Rajiv D. Machado et al.   HUMAN MUTATION

Protein expression by human pulmonary artery smooth muscle cells containing a BMPR2 mutation and the action of ET-1 as determined by proteomic mass spectrometry

(2015) Chunxiang Yao et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension

(2015) Abdul Q. Sheikh et al.   Science Translational Medicine

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells

(2015) Ruslan Rafikov et al.   Redox Biology

The Metabolic Basis of Pulmonary Arterial Hypertension

(2014) Gopinath Sutendra et al.   Cell Metabolism

Protein kinase RNA-like endoplasmic reticulum kinase (PERK)/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy

(2014) Zhongwei Liu et al.   CELLULAR SIGNALLING

Progranulin Transcripts with Short and Long 5′ Untranslated Regions (UTRs) Are Differentially Expressed via Posttranscriptional and Translational Repression

(2014) Anja Capell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-124/ATF-6, A Novel Lifespan Extension Pathway ofAstragalusPolysaccharide inCaenorhabditis Elegans

(2014) Ning Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6  Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

(2014) A. Higa et al.   MOLECULAR AND CELLULAR BIOLOGY

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

(2014) Rajkumar Savai et al.   NATURE MEDICINE

Metabolomic Heterogeneity of Pulmonary Arterial Hypertension

(2014) Yidan Zhao et al.   PLoS One

α-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson’s Disease

(2014) Dilshan S. Harischandra et al.   TOXICOLOGICAL SCIENCES

MicroRNA-124 Suppresses the Transactivation of Nuclear Factor of Activated T Cells by Targeting Multiple Genes and Inhibits the Proliferation of Pulmonary Artery Smooth Muscle Cells

(2013) Kang Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Synergy Screen and Network Modeling in Dedifferentiated Liposarcoma Identifies CDK4 and IGF1R as Synergistic Drug Targets

(2013) M. L. Miller et al.   Science Signaling

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Attenuating Endoplasmic Reticulum Stress as a Novel Therapeutic Strategy in Pulmonary Hypertension

(2012) Peter Dromparis et al.   CIRCULATION

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Proteomic Profile of Circulating Pentraxin 3 (PTX3) Complex in Sepsis Demonstrates the Interaction with Azurocidin 1 and Other Components of Neutrophil Extracellular Traps

(2012) Kenji Daigo et al.   MOLECULAR & CELLULAR PROTEOMICS

Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification

(2011) Marcel Liberman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Nogo and the Mitochondria-Endoplasmic Reticulum Unit in Pulmonary Hypertension

(2011) G. Sutendra et al.   Science Translational Medicine

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

The role of mitochondria in pulmonary vascular remodeling

(2010) Peter Dromparis et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect

(2009) Sean P Pitroda et al.   BMC Medicine

TRPC1 and STIM1 mediate capacitative Ca2+entry in mouse pulmonary arterial smooth muscle cells

(2009) Lih Chyuan Ng et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetics and Genomics of Pulmonary Arterial Hypertension

(2009) Rajiv D. Machado et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

(2008) A. Sobolewski et al.   HUMAN MOLECULAR GENETICS