The Microbial Metabolite Trimethylamine N-Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis
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Title
The Microbial Metabolite Trimethylamine N-Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis
Authors
Keywords
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Journal
Nutrients
Volume 11, Issue 8, Pages 1821
Publisher
MDPI AG
Online
2019-08-07
DOI
10.3390/nu11081821
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Note: Only part of the references are listed.- Trimethylamine N-Oxide and Cardiovascular Outcomes in Patients with End-stage Kidney Disease Receiving Maintenance Hemodialysis
- (2019) Jason R. Stubbs et al. Clinical Journal of the American Society of Nephrology
- ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome
- (2019) Xiwen Dong et al. Cellular & Molecular Immunology
- Rheumatoid arthritis (RA) and cardiovascular disease
- (2019) Arnon Blum et al. AUTOIMMUNITY REVIEWS
- Immunometabolism orchestrates training of innate immunity in atherosclerosis
- (2019) Julia van Tuijl et al. CARDIOVASCULAR RESEARCH
- Trimethylamine N-oxide promotes tissue factor expression and activity in vascular endothelial cells: A new link between trimethylamine N-oxide and atherosclerotic thrombosis
- (2019) Xiaoye Cheng et al. THROMBOSIS RESEARCH
- Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes
- (2018) Arash Haghikia et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Metabolic products of the intestinal microbiome and extremes of atherosclerosis
- (2018) Chrysi Bogiatzi et al. ATHEROSCLEROSIS
- Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease
- (2018) Tiejun Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of Microtubule Depolymerization by Osmolytes
- (2018) George D. Bachand et al. BIOMACROMOLECULES
- Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway
- (2018) Jin Geng et al. BIOMEDICINE & PHARMACOTHERAPY
- Synthetic capacity does not predict elasmobranchs' ability to maintain trimethylamine oxide without a dietary contribution
- (2018) Abigail B. Bockus et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
- Changes in Gut Microbiota–Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial
- (2018) Yoriko Heianza et al. DIABETES CARE
- Decreased Kidney Function is Associated with Enhanced Hepatic Flavin Monooxygenase Activity and Increased Circulating Trimethylamine N-oxide Concentrations in Mice
- (2018) Cassandra Johnson et al. DRUG METABOLISM AND DISPOSITION
- Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis
- (2018) Dragana Dragoljevic et al. EUROPEAN HEART JOURNAL
- The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease
- (2018) Stefanie Ascher et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo
- (2018) Suwen Liu et al. FOOD RESEARCH INTERNATIONAL
- Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress
- (2018) Yilang Ke et al. FREE RADICAL BIOLOGY AND MEDICINE
- Uremic toxins are conditional danger- or homeostasis-associated molecular patterns
- (2018) Rongshan Li Frontiers in Bioscience-Landmark
- Plasma trimethylamine N-oxide is associated with vulnerable plaque characteristics in CAD patients as assessed by optical coherence tomography
- (2018) Xinxin Liu et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Biomarkers (plasma trimethylamine- N -oxide) to predict atrial fibrillation: Are we there yet?
- (2018) Mihail G. Chelu et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Enterococcus faecium WEFA23 from infant lessens high-fat-diet-induced hyperlipidemia via cholesterol 7-alpha-hydroxylase gene by altering the composition of gut microbiota in rats
- (2018) Fuqing Huang et al. JOURNAL OF DAIRY SCIENCE
- Effects of Urea and TMAO on Lipid Self-Assembly under Osmotic Stress Conditions
- (2018) Quoc Dat Pham et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
- (2018) W. Zhu et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Osmolyte Adjustments as a Pressure Adaptation in Deep-Sea Chondrichthyan Fishes: An Intraspecific Test in Arctic Skates (Amblyraja hyperborea) along a Depth Gradient
- (2018) Paul H. Yancey et al. PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
- Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity
- (2018) Jin Bu et al. Gastroenterology Research and Practice
- Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression
- (2018) Esmeralda Castillo-Rodriguez et al. Toxins
- The Osmolyte TMAO Modulates Protein Folding Cooperativity by Altering Global Protein Stability
- (2018) Prashant N. Jethva et al. BIOCHEMISTRY
- Contribution of the commensal microbiota to atherosclerosis and arterial thrombosis
- (2018) Klytaimnistra Kiouptsi et al. BRITISH JOURNAL OF PHARMACOLOGY
- NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
- (2018) C Guo et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells
- (2018) Birgit Zimmermann-Geller et al. IMMUNOLOGY AND CELL BIOLOGY
- Noncovalent Interactions between Trimethylamine N-Oxide (TMAO), Urea, and Water
- (2018) Sarah G. Zetterholm et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Dietary patterns and components to prevent and treat heart failure: a comprehensive review of human studies
- (2018) Conor P. Kerley NUTRITION RESEARCH REVIEWS
- Renal Manifestations of Rheumatoid Arthritis
- (2018) Teja Kapoor et al. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
- A Multi-omic Association Study of Trimethylamine N-Oxide
- (2018) Ohad Manor et al. Cell Reports
- Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function
- (2018) Marina Canyelles et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis
- (2018) Anna Reustle et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Prevalence and predictive value of high-positive rheumatoid factor and anti-citrullinated protein antibody levels in nonarthritic patients with chronic hepatitis C infection
- (2018) Ko-Ming Lin et al. International Journal of Rheumatic Diseases
- l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
- (2018) Robert A. Koeth et al. JOURNAL OF CLINICAL INVESTIGATION
- Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
- (2018) Lin Ding et al. Lipids in Health and Disease
- Dietary metabolism, the gut microbiome, and heart failure
- (2018) W. H. Wilson Tang et al. Nature Reviews Cardiology
- Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study
- (2018) Zhao-Yan Liu et al. Nutrition & Metabolism
- Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome
- (2018) Luigi Barrea et al. Nutrients
- The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
- (2018) Nicholas M. Vogt et al. Alzheimers Research & Therapy
- Targeting cell adhesion molecules with nanoparticles using in vivo and flow-based in vitro models of atherosclerosis
- (2017) Khosrow Khodabandehlou et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- High titer of anti-citrullinated peptide antibody is a risk factor for severe carotid atherosclerotic plaque in patients with rheumatoid arthritis: the TOMORROW study
- (2017) Tadashi Okano et al. International Journal of Rheumatic Diseases
- Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm
- (2017) Aakanksha Jain et al. JOURNAL OF IMMUNOLOGY
- Trimethylamine N-oxide Counteracts Urea Denaturation by Inhibiting Protein–Urea Preferential Interaction
- (2017) Pritam Ganguly et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- End-stage renal disease in patients with rheumatoid arthritis
- (2017) Sunita Paudyal et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- Trimethylamine- N -Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?
- (2017) Clara E. Cho et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent
- (2017) Mikiko Kobayashi et al. VIRCHOWS ARCHIV
- Association of Anti-Citrullinated Peptide Antibodies With Coronary Artery Calcification in Rheumatoid Arthritis
- (2017) Laura Geraldino-Pardilla et al. ARTHRITIS CARE & RESEARCH
- Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway
- (2017) Ming‐liang Chen et al. Journal of the American Heart Association
- Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide Contributes to Cardiac Dysfunction in Western Diet-Induced Obese Mice
- (2017) Kui Chen et al. Frontiers in Physiology
- Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress
- (2017) Tiejun Li et al. Frontiers in Physiology
- Enterotypes in the landscape of gut microbial community composition
- (2017) Paul I. Costea et al. Nature Microbiology
- Inflammation in atherosclerosis
- (2016) Soraya Taleb Archives of Cardiovascular Diseases
- Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome
- (2016) Xiaolei Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
- (2016) Weifei Zhu et al. CELL
- Formation of propionate and butyrate by the human colonic microbiota
- (2016) Petra Louis et al. ENVIRONMENTAL MICROBIOLOGY
- Effect of Trimethylamine N-Oxide on Interfacial Electrostatics at Phospholipid Monolayer–Water Interfaces and Its Relevance to Cardiovascular Disease
- (2016) Jahur A. Mondal Journal of Physical Chemistry Letters
- ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model
- (2016) Amy M. Archer et al. Journal of Translational Medicine
- Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial
- (2016) Clara E. Cho et al. MOLECULAR NUTRITION & FOOD RESEARCH
- The microbiota in adaptive immune homeostasis and disease
- (2016) Kenya Honda et al. NATURE
- Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
- (2016) Ming-liang Chen et al. mBio
- Revised Estimates for the Number of Human and Bacteria Cells in the Body
- (2016) Ron Sender et al. PLOS BIOLOGY
- Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort
- (2016) Vichai Senthong et al. Journal of the American Heart Association
- Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
- (2016) Marcus M. Seldin et al. Journal of the American Heart Association
- The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review
- (2016) Xue Zhao et al. Journal of Diabetes Research
- Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease
- (2016) Catharina Missailidis et al. PLoS One
- Anti-citrullinated-protein-antibody-specific intravenous immunoglobulin attenuates collagen-induced arthritis in mice
- (2015) N. Svetlicky et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study
- (2015) Aki Mafune et al. Clinical and Experimental Nephrology
- Reduction in keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N-oxide
- (2015) Mbarka Bchetnia et al. EXPERIMENTAL DERMATOLOGY
- Trimethylamine-N-Oxide Treatment Induces Changes in the ATP-Binding Cassette Transporter A1 and Scavenger Receptor A1 in Murine Macrophage J774A.1 cells
- (2015) Abbas Mohammadi et al. INFLAMMATION
- Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway
- (2015) Xiaojin Sha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden
- (2015) J. R. Stubbs et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- TMAO: A small molecule of great expectations
- (2015) Marcin Ufnal et al. NUTRITION
- Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis
- (2015) Kim L.L. Habets et al. ARTHRITIS RESEARCH & THERAPY
- Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota
- (2015) Wei-Kai Wu et al. Journal of Functional Foods
- Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide
- (2015) Kymberleigh A. Romano et al. mBio
- Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains
- (2015) Brian J. Bennett et al. PLoS Genetics
- Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study
- (2014) Carolyn A Miller et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats
- (2014) Marcin Ufnal et al. CANADIAN JOURNAL OF CARDIOLOGY
- Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
- (2014) Xiang Gao et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- How citrullination invaded rheumatoid arthritis research
- (2014) Walther J van Venrooij et al. ARTHRITIS RESEARCH & THERAPY
- Rheumatoid arthritis increases the risk of deep vein thrombosis and pulmonary thromboembolism: a nationwide cohort study
- (2013) Wei-Sheng Chung et al. ANNALS OF THE RHEUMATIC DISEASES
- Brief Report: Citrullination Within the Atherosclerotic Plaque: A Potential Target for the Anti-Citrullinated Protein Antibody Response in Rheumatoid Arthritis
- (2013) Jeremy Sokolove et al. ARTHRITIS AND RHEUMATISM
- Gut microbiota metabolism of l-carnitine and cardiovascular risk
- (2013) John R. Ussher et al. ATHEROSCLEROSIS
- Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
- (2013) Brian J. Bennett et al. Cell Metabolism
- Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity
- (2013) Samuel B. Brusca et al. CURRENT OPINION IN RHEUMATOLOGY
- Rheumatoid arthritis and risk of acute myocardial infarction—A nationwide retrospective cohort study
- (2013) Wei-Sheng Chung et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention
- (2013) Ron T Gansevoort et al. LANCET
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
- (2013) W.H. Wilson Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
- (2013) Jose U Scher et al. eLife
- Mapping pathogenesis of arthritis through small animal models
- (2012) T. L. Vincent et al. RHEUMATOLOGY
- Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
- (2011) Camille M Balarini et al. Lipids in Health and Disease
- The Pathogenesis of Rheumatoid Arthritis
- (2011) Iain B. McInnes et al. NEW ENGLAND JOURNAL OF MEDICINE
- Renal co-morbidity in patients with rheumatic diseases
- (2011) Hans-Joachim Anders et al. ARTHRITIS RESEARCH & THERAPY
- Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
- (2010) Giovanni Musso et al. Annual Review of Medicine
- Dimethylamine and diet
- (2008) S.C. Mitchell et al. FOOD AND CHEMICAL TOXICOLOGY
- Evidence that cytokines play a role in rheumatoid arthritis
- (2008) Fionula M. Brennan et al. JOURNAL OF CLINICAL INVESTIGATION
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