Emerging roles of Dectin-1 in noninfectious settings and in the CNS

Dectin-1 is a C-type lectin receptor (CLR) expressed on the surface of various mammalian myeloid cells. Dectin-1 recognizes beta-glucans and elicits antifungal proinflammatory immune responses. Recent studies have begun to examine the biology of Dectin-1 in previously less explored settings, such as homeostasis, sterile inflammation, and in the central nervous system. Indeed, in certain contexts, Dectin-1 is now known to promote tolerance, and anti-inflammatory and neuroprotective responses. In this review, we provide an overview of the current understanding of the roles of Dectin-1 in immunology beyond the context of fungal infections, mainly focusing on in vivo neuroimmunology studies, which could reveal new therapeutic approaches to modify innate immune responses in neurologic disorders.

Automated summary

Dectin-1, a C-type lectin receptor expressed on myeloid cells, recognizes beta-glucans and induces antifungal proinflammatory immune responses. Apart from its known role in fungal infections, Dectin-1 has been found to promote tolerance, anti-inflammatory, and neuroprotective responses in certain contexts. Studies in neuroimmunology suggest potential new therapeutic approaches for modifying innate immune responses in neurological disorders.