Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy

Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

(2021) Wenchao Zhang et al.   Scientific Reports

A deleterious interplay between endoplasmic reticulum stress and its functional linkage to mitochondria in nephrolithiasis

(2021) Minu Sharma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

(2021) Xingxing Li et al.   npj Biofilms and Microbiomes

High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

(2021) Woongjae Yoo et al.   SCIENCE

Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation

(2021) Zulong Xie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Probiotic Lactiplantibacillus plantarum N‐1 could prevent ethylene glycol‐induced kidney stones by regulating gut microbiota and enhancing intestinal barrier function

(2021) Zhitao Wei et al.   FASEB JOURNAL

Trimethylamine N‐oxide promotes apoE −/− mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

(2020) Peng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fatty acid binding protein 4 down regulation drives calcification in the development of kidney stone disease

(2020) Kazumi Taguchi et al.   KIDNEY INTERNATIONAL

Predictive Factors for Kidney Stone Recurrence in Type 2 Diabetes Mellitus

(2020) Phornphen Prasanchaimontri et al.   UROLOGY

The relationship between gut microbiota and short chain fatty acids in the renal calcium oxalate stones disease

(2020) Yu Liu et al.   FASEB JOURNAL

Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy

(2020) Yingfeng Shi et al.   Cell Death & Disease

Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

(2020) Jianjun Qi et al.   Cell Death & Disease

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

(2020) Wojciech Ornatowski et al.   Redox Biology

Pathophysiology and Treatment of Enteric Hyperoxaluria

(2020) Celeste Witting et al.   Clinical Journal of the American Society of Nephrology

Microbiota, diet and the generation of reactive nitrogen compounds

(2020) Mattias Carlström et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway

(2020) Rong Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Impact of Phyllantus niruri and Lactobacillus amylovorus SGL 14 in a mouse model of dietary hyperoxaluria

(2020) L. Manna et al.   Beneficial Microbes

Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency

(2020) Magnhild E. Macpherson et al.   Frontiers in Immunology

ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury

(2020) Suhan Zhou et al.   Acta Physiologica

Inhibition of urinary stone disease by a multi-species bacterial network ensures healthy oxalate homeostasis

(2019) Aaron Miller et al.   KIDNEY INTERNATIONAL

CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma

(2019) Zongyi Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells

(2019) Xuan Zhao et al.   Autophagy

Gut microbiome and kidney stone disease: not just an Oxalobacter story

(2019) Andrea Ticinesi et al.   KIDNEY INTERNATIONAL

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

FMO3 and its metabolite TMAO contribute to the formation of gallstones

(2019) Yaoyao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

LncRNA HOXA11‐AS regulates calcium oxalate crystal–induced renal inflammation via miR‐124‐3p/MCP‐1

(2019) Yinhui Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effect of endoplasmic reticulum stress-mediated excessive autophagy on apoptosis and formation of kidney stones

(2019) Yan Sun et al.   LIFE SCIENCES

H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway

(2019) Haoran Liu et al.   EBioMedicine

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites

(2018) Shiho Fujisaka et al.   Cell Reports

Autophagy inhibition attenuates hyperoxaluria-induced renal tubular oxidative injury and calcium oxalate crystal depositions in the rat kidney

(2018) Xiaolu Duan et al.   Redox Biology

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

Dysregulated autophagy contributes to caspase-dependent neuronal apoptosis

(2018) Yuhyun Chung et al.   Cell Death & Disease

Fenofibrate improves vascular endothelial function and contractility in diabetic mice

(2018) Nan Xu et al.   Redox Biology

Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate

(2018) Jianning Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Uncovering the trimethylamine-producing bacteria of the human gut microbiota

(2017) Silke Rath et al.   Microbiome

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

(2016) Man J. Livingston et al.   Autophagy

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Genome-Wide Gene Expression Profiling of Randall’s Plaques in Calcium Oxalate Stone Formers

(2016) Kazumi Taguchi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease

(2016) Shrikant R. Mulay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

(2016) Shrikant R. Mulay et al.   Nature Communications

Hyperoxaluria leads to dysbiosis and drives selective enrichment of oxalate metabolizing bacterial species in recurrent kidney stone endures

(2016) Mangesh V. Suryavanshi et al.   Scientific Reports

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Autophagy in Kidney Health and Disease

(2013) Zhibo Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy

(2013) Felix Knauf et al.   KIDNEY INTERNATIONAL

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Update on Oxalate Crystal Disease

(2013) Elizabeth C. Lorenz et al.   Current Rheumatology Reports

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients

(2011) Ilse Vanhorebeek et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Under the ROS: Thiol network is the principal suspect for autophagy commitment

(2010) Giuseppe Filomeni et al.   Autophagy

Targeting ER stress induced apoptosis and inflammation in cancer

(2010) Tom Verfaillie et al.   CANCER LETTERS

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Kidney Stones and the Risk for Chronic Kidney Disease

(2009) A. D. Rule et al.   Clinical Journal of the American Society of Nephrology

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk Between Autophagy and Apoptosis in Heart Disease

(2008) Kazuhiko Nishida et al.   CIRCULATION RESEARCH

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

(2008) Sudharsan Periyasamy-Thandavan et al.   KIDNEY INTERNATIONAL