High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

(2017) W.H. Wilson Tang et al.   Translational Research

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

(2017) Tiejun Li et al.   Frontiers in Physiology

Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD

(2017) Mohammed Al-Obaide et al.   Journal of Clinical Medicine

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

TNF-α Activates High-Mobility Group Box 1 - Toll-Like Receptor 4 Signaling Pathway in Human Aortic Endothelial Cells

(2016) Won Seok Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

(2016) Yang Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation

(2016) Lei Wang et al.   Oncotarget

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis

(2015) Yang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1

(2015) Yang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk

(2015) Luca Miele et al.   Current Cardiology Reports

Endothelial Cell Permeability and Adherens Junction Disruption Induced by Junín Virus Infection

(2014) Heather M. Lander et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

The contributory role of gut microbiota in cardiovascular disease

(2014) W.H. Wilson Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-Like Receptor 4 Upregulation by Angiotensin II Contributes to Hypertension and Vascular Dysfunction through Reactive Oxygen Species Production

(2014) Priscila R. De Batista et al.   PLoS One

HMGB1-Promoted and TLR2/4-Dependent NK Cell Maturation and Activation Take Part in Rotavirus-Induced Murine Biliary Atresia

(2014) Yinrong Qiu et al.   PLoS Pathogens

Tight junction proteins: From barrier to tumorigenesis

(2013) E. Aaron Runkle et al.   CANCER LETTERS

Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in l-NAME-induced hypertension

(2013) Daniel Sollinger et al.   CARDIOVASCULAR RESEARCH

VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity

(2013) Monica Giannotta et al.   DEVELOPMENTAL CELL

Atrial endothelial impairment through Toll-like receptor 4 signaling causes atrial thrombogenesis

(2013) Shigehiko Katoh et al.   HEART AND VESSELS

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective

(2013) Ishwarlal Jialal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury

(2013) Zhongwei Yang et al.   LABORATORY INVESTIGATION

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis

(2012) A.W.S. de Souza et al.   AUTOIMMUNITY REVIEWS

Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats

(2012) Gisele F. Bomfim et al.   CLINICAL SCIENCE

Relationship of Soluble RAGE and RAGE Ligands HMGB1 and EN-RAGE to Endothelial Dysfunction in Type 1 and Type 2 Diabetes Mellitus

(2012) J. Škrha Jr et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

TLR2 and TLR4 Gene Expression in Peripheral Monocytes in Nondiabetic Hypertensive Patients: The Effect of Intensive Blood Pressure-Lowering

(2012) Maria E. Marketou et al.   Journal of Clinical Hypertension

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

HMGB1 Is Associated with Atherosclerotic Plaque Composition and Burden in Patients with Stable Coronary Artery Disease

(2012) Martin Andrassy et al.   PLoS One

Hypertension augments cardiac Toll-like receptor 4 expression and activity

(2011) Ruth Eißler et al.   HYPERTENSION RESEARCH

HMGB1 Increases Permeability of the Endothelial Cell Monolayer via RAGE and Src Family Tyrosine Kinase Pathways

(2011) Wenchang Huang et al.   INFLAMMATION

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

(2010) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Toll like receptor 4 in atherosclerosis and plaque destabilization

(2009) Wijnand K. den Dekker et al.   ATHEROSCLEROSIS

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients

(2008) Xiao Xiang Yan et al.   ATHEROSCLEROSIS

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

(2007) Yann Wallez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES