Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux

Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo

(2021) Sergio Diaz-Rodriguez et al.   EUROPEAN HEART JOURNAL

Oxidative Stress Triggers Defective Autophagy in Endothelial Cells: Role in Atherothrombosis Development

(2021) Cristina Carresi et al.   Antioxidants

New challenges in vascular biology and medicine: from unravelling the mechanisms of neointima formation to the prevention of amputations and of ischaemic stroke

(2021) Filippo Crea   EUROPEAN HEART JOURNAL

Nkx2‐3 induces autophagy inhibiting proliferation and migration of vascular smooth muscle cells via AMPK/mTOR signaling pathway

(2021) Huajun Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway

(2021) Weifei Zhu et al.   Cell Host & Microbe

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

(2021) Shan Jiang et al.   Redox Biology

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

(2021) BingYu Wang et al.   Frontiers in Cardiovascular Medicine

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

(2020) Xiuli Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trimethylamine N‐oxide promotes apoE −/− mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

(2020) Peng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Late Endothelial progenitor cell-capture stents with CD146 antibody and nanostructure reduce in-stent restenosis and thrombosis

(2020) Kwang-Sook Park et al.   Acta Biomaterialia

Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates with Vascular Risks and Is Involved in Atherosclerosis

(2020) Liliana Perdomo et al.   CIRCULATION RESEARCH

Gut Microbiota and Cardiovascular Disease

(2020) Marco Witkowski et al.   CIRCULATION RESEARCH

Drp-1 as Potential Therapeutic Target for Lipopolysaccharide-Induced Vascular Hyperpermeability

(2020) Xu Luo et al.   Oxidative Medicine and Cellular Longevity

Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing

(2020) Amir Ajoolabady et al.   AGEING RESEARCH REVIEWS

The complex biology of the arterial wall: much more than endothelial dysfunction and atherosclerosis

(2020) Filippo Crea   EUROPEAN HEART JOURNAL

Reassessing the Mechanisms of Acute Coronary Syndromes

(2019) Peter Libby et al.   CIRCULATION RESEARCH

FoxO1 inhibits autophagosome-lysosome fusion leading to endothelial autophagic-apoptosis in diabetes

(2019) Hui Zhang et al.   CARDIOVASCULAR RESEARCH

Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption

(2019) Antony Leonard et al.   CELLULAR SIGNALLING

The roles of oxidative stress and Beclin-1 in the autophagosome clearance impairment triggered by cardiac arrest

(2019) Xintao Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction

(2019) Gurinder Bir Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Crucial Role for Diet in the Relationship Between Gut Microbiota and Cardiometabolic Disease

(2019) Ilias Attaye et al.   Annual Review of Medicine

Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet

(2019) Yun-Ting Wang et al.   Cell Death & Disease

Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy

(2019) Jingjing Liu et al.   Journal of Diabetes Research

Association between plasma trimethylamine N-oxide and neoatherosclerosis in patients with very late stent thrombosis

(2019) Yu Tan et al.   CANADIAN JOURNAL OF CARDIOLOGY

Thrombotic Regulation From the Endothelial Cell Perspectives

(2018) Miao Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Erratum to Gut flora-dependent metabolite trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress [Free Radic. Biol. Med. 116C (2018) 88–100]

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

Dietary metabolism, the gut microbiome, and heart failure

(2018) W. H. Wilson Tang et al.   Nature Reviews Cardiology

A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells

(2018) Yerin Kim et al.   Scientific Reports

Mussel-inspired dopamine-CuII coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis

(2018) Feng Zhang et al.   BIOMATERIALS

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

(2017) Gabriele Giacomo Schiattarella et al.   EUROPEAN HEART JOURNAL

Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications

(2017) Bian Wu et al.   MOLECULAR ASPECTS OF MEDICINE

The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis

(2016) Karolina Skagen et al.   ATHEROSCLEROSIS

Endothelial cells: source, barrier, and target of defensive mediators

(2016) Lubka T. Roumenina et al.   IMMUNOLOGICAL REVIEWS

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

(2015) Mandy OJ Grootaert et al.   Autophagy

The Role of Autophagy in Vascular Biology

(2015) S. C. Nussenzweig et al.   CIRCULATION RESEARCH

Autophagy in Vascular Disease

(2015) G. R. Y. De Meyer et al.   CIRCULATION RESEARCH

Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients With Primary Hyperaldosteronemia

(2015) Long Chen et al.   HYPERTENSION

Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy

(2015) DONGDONG CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Beclin 1 knockdown retards re-endothelialization and exacerbates neointimal formation via a crosstalk between autophagy and apoptosis

(2014) Lan-Xiang Ye et al.   ATHEROSCLEROSIS

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Differential clinical outcomes after 1 year versus 5 years in a randomised comparison of zotarolimus-eluting and sirolimus-eluting coronary stents (the SORT OUT III study): a multicentre, open-label, randomised superiority trial

(2014) Michael Maeng et al.   LANCET

Saphenous Vein Graft Failure After Coronary Artery Bypass Surgery

(2013) Ralf E. Harskamp et al.   ANNALS OF SURGERY

Oxidative Stress and Pathological Changes After Coronary Artery Interventions

(2013) Rio P. Juni et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy is impaired in cardiac ischemia-reperfusion injury

(2012) Xiucui Ma et al.   Autophagy

Inhibition of miR-92a increases endothelial proliferation and migration in vitro as well as reduces neointimal proliferation in vivo after vascular injury

(2012) Claudio Iaconetti et al.   BASIC RESEARCH IN CARDIOLOGY

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

(2012) Xiucui Ma et al.   CIRCULATION

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats

(2011) Matthew J. Alef et al.   JOURNAL OF CLINICAL INVESTIGATION

Nox Activator 1

(2010) Xi-Lin Niu et al.   CIRCULATION

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of allograft inflammatory factor-1 expression reduces development of neointimal hyperplasia and p38 kinase activity

(2008) Laura J. Sommerville et al.   CARDIOVASCULAR RESEARCH

Modified Prosthetic Vascular Conduits

(2008) Muneera R. Kapadia et al.   CIRCULATION