Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD

A Novel Subset of CD95+ Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity

(2021) Candice Johnson et al.   Frontiers in Immunology

Trained Immunity: Reprogramming Innate Immunity in Health and Disease

(2021) Siroon Bekkering et al.   Annual Review of Immunology

Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance

(2021) Qian Yang et al.   Journal of Immunology Research

Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair

(2021) Ruijing Zhang et al.   Frontiers in Immunology

Histone deacetylase‑2: A potential regulator and therapeutic target in liver disease (Review)

(2021) Ya-Ru Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulation and functional roles of chemokines in liver diseases

(2021) Sheng Cao et al.   Nature Reviews Gastroenterology & Hepatology

Pathogenetic mechanisms of nonalcoholic fatty liver disease and inhibition of the inflammasome as a new therapeutic target

(2021) Yasar Colak et al.   Clinics and Research in Hepatology and Gastroenterology

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

(2021) Mengqing Jiang et al.   Frontiers in Pharmacology

Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways

(2021) Dong Ni et al.   Frontiers in Immunology

Caspase-11–Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis

(2021) Yingwei Zhu et al.   Cellular and Molecular Gastroenterology and Hepatology

Role of the inflammasome, gasdermin D, and pyroptosis in non‐alcoholic fatty liver disease

(2021) Itzayana Rodríguez‐Antonio et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

(2021) Ying Shao et al.   Frontiers in Immunology

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Trained Immunity: An Underlying Driver of Inflammatory Atherosclerosis

(2020) Chao Zhong et al.   Frontiers in Immunology

End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression

(2020) Ruijing Zhang et al.   Redox Biology

Vascular Endothelial Cells and Innate Immunity

(2020) Ying Shao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcriptional Regulation in Non-Alcoholic Fatty Liver Disease

(2020) Sandra Steensels et al.   Metabolites

OxLDL-mediated immunologic memory in endothelial cells

(2020) Yahya Sohrabi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia

(2020) Teresa Płatek et al.   MOLECULAR MEDICINE

Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators

(2020) Ming Liu et al.   Frontiers in Immunology

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

(2020) Alexander M. Fagenson et al.   Pathogens

Trained Immunity and Reactivity of Macrophages and Endothelial Cells

(2020) Charles Drummer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

(2019) Siroon Bekkering et al.   Cell Metabolism

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System

(2019) Bo Yang et al.   Frontiers in Neurology

Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs

(2019) Yifan Lu et al.   Redox Biology

Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors

(2019) Bin Lai et al.   Frontiers in Immunology

Nutrition and Nonalcoholic Fatty Liver Disease

(2019) Manu V. Chakravarthy et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling

(2019) Wen Shen et al.   Redox Biology

Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells

(2019) Xinyuan Li et al.   Redox Biology

Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury

(2018) Ying Shao et al.   ANTIOXIDANTS & REDOX SIGNALING

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Lipid Peroxidation Adds Fuel to Pyr(optosis)

(2018) Ashley J. Russo et al.   Cell Host & Microbe

Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights

(2018) Kristen Stephenson et al.   GENE EXPRESSION

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation

(2018) Xinyuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Omega-6 fatty acids and inflammation

(2018) Jacqueline K. Innes et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3

(2018) Luke A.J. O’Neill et al.   TRENDS IN MOLECULAR MEDICINE

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg

(2018) Keman Xu et al.   Frontiers in Immunology

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse Model

(2018) Jung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

(2017) Vanessa D. de Mello et al.   Epigenetics

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

(2017) Ya-feng Li et al.   Journal of Hematology & Oncology

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

The third path of tubulointerstitial fibrosis: aberrant endothelial secretome

(2017) Mark Lipphardt et al.   KIDNEY INTERNATIONAL

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation

(2017) Martina B. Lorey et al.   MOLECULAR & CELLULAR PROTEOMICS

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

Pathways of Unconventional Protein Secretion

(2017) Catherine Rabouille   TRENDS IN CELL BIOLOGY

Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide

(2017) Mikhaïl Van Herck et al.   Nutrients

Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking

(2017) Qian Yang et al.   Frontiers in Physiology

Epigenetics and Trained Immunity

(2017) Charlotte D.C.C. van der Heijden et al.   ANTIOXIDANTS & REDOX SIGNALING

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

(2017) Y. Yin et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

IL-35, as a newly proposed homeostasis-associated molecular pattern, plays three major functions including anti-inflammatory initiator, effector, and blocker in cardiovascular diseases

(2017) Xinyuan Li et al.   CYTOKINE

Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair

(2016) Cong-xin Huang   Frontiers in Bioscience-Landmark

Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway

(2016) Jietang Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease

(2016) Anthony Virtue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

(2016) Luqiao Wang et al.   Journal of Hematology & Oncology

Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets—“Sand Out and Gold Stays”

(2016) Ying Shao et al.   Journal of Cardiovascular Translational Research

Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery

(2016) Lucas M. Ferrer et al.   Journal of Cardiovascular Translational Research

Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

(2016) Xin Wang et al.   Journal of Cardiovascular Translational Research

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrative Genomic Signatures Of Hepatocellular Carcinoma Derived from Nonalcoholic Fatty Liver Disease

(2015) Itziar Frades et al.   PLoS One

Hyperhomocysteinemia Potentiates Hyperglycemia-Induced Inflammatory Monocyte Differentiation and Atherosclerosis

(2014) P. Fang et al.   DIABETES

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders

(2014) Payman Shahabi et al.   PHARMACOLOGY & THERAPEUTICS

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Prevalence and associated metabolic factors of fatty liver disease in the elderly

(2013) Zhongli Wang et al.   EXPERIMENTAL GERONTOLOGY

Inflammasomes: sensors of metabolic stresses for vascular inflammation 

(2013) Xiao-feng Yang   Frontiers in Bioscience-Landmark

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Identification of Novel Pretranslational Regulatory Mechanisms for NF-κB Activation

(2013) Xiao Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An evolving new paradigm: endothelial cells – conditional innate immune cells

(2013) Jietang Mai et al.   Journal of Hematology & Oncology

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Human housekeeping genes, revisited

(2013) Eli Eisenberg et al.   TRENDS IN GENETICS

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Severe Hyperhomocysteinemia Promotes Bone Marrow–Derived and Resident Inflammatory Monocyte Differentiation and Atherosclerosis in LDLr/CBS-Deficient Mice

(2012) Daqing Zhang et al.   CIRCULATION RESEARCH

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

(2012) Janna A. van Diepen et al.   JOURNAL OF LIPID RESEARCH

IL-35 Is a Novel Responsive Anti-inflammatory Cytokine — A New System of Categorizing Anti-inflammatory Cytokines

(2012) Xinyuan Li et al.   PLoS One

Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis

(2012) Yuki Kita et al.   PLoS One

Role of cytokines and chemokines in non-alcoholic fatty liver disease

(2012) Vincent Braunersreuther   WORLD JOURNAL OF GASTROENTEROLOGY

Functional Analyses of Two Acetyl Coenzyme A Synthetases in the Ascomycete Gibberella zeae

(2011) Seunghoon Lee et al.   EUKARYOTIC CELL

The human primary hepatocyte transcriptome reveals novel insights into atorvastatin and rosuvastatin action

(2011) Mateja Hafner et al.   Pharmacogenetics and Genomics

Regulation of homocysteine metabolism and methylation in human and mouse tissues

(2010) Natalie C. Chen et al.   FASEB JOURNAL

Signalling to and from the secretory pathway

(2010) H. Farhan et al.   JOURNAL OF CELL SCIENCE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Role of Alcohol Metabolism in Non-Alcoholic Steatohepatitis

(2010) Susan S. Baker et al.   PLoS One

Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease

(2010) Hari Manev et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Caspase-1 recognizes extended cleavage sites in its natural substrates

(2009) Jerry Shen et al.   ATHEROSCLEROSIS

Hyperhomocysteinemia Promotes Inflammatory Monocyte Generation and Accelerates Atherosclerosis in Transgenic Cystathionine β-Synthase–Deficient Mice

(2009) Daqing Zhang et al.   CIRCULATION

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice

(2008) Shuqin Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility

(2008) Yi-Jen Liao et al.   INTERNATIONAL JOURNAL OF CANCER