Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS‐induced cell apoptosis

(2021) Zhencan Shi et al.   AGING CELL

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

(2020) Xiuli Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The global epidemiology of hypertension

(2020) Katherine T. Mills et al.   Nature Reviews Nephrology

Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation

(2020) Xinyu Yang et al.   Redox Biology

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction

(2020) Xiaowei Xiong et al.   BIOMEDICINE & PHARMACOTHERAPY

Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

(2020) Jianjun Qi et al.   Cell Death & Disease

Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca 2+ Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress

(2020) Xiang-Qun Hu et al.   HYPERTENSION

Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure

(2020) Bina Joe et al.   HYPERTENSION

ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway

(2020) Zhida Chen et al.   Cell Death & Disease

High phosphate impairs arterial endothelial function through AMPK‐related pathways in mouse resistance arteries

(2020) Weipeng Hu et al.   Acta Physiologica

Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension

(2019) Ravindra K Sharma et al.   CIRCULATION RESEARCH

Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8 T cells

(2019) Katie Hurst et al.   Cancer Immunology Research

Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm

(2019) Fumiaki Shikata et al.   HYPERTENSION

Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes

(2019) Signe A. Winther et al.   DIABETES CARE

Redox-sensitive calcium/calmodulin-dependent protein kinase IIα in angiotensin II intra-neuronal signaling and hypertension

(2019) Urmi Basu et al.   Redox Biology

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

High-Protein Diet–Induced Glomerular Hyperfiltration Is Dependent on Neuronal Nitric Oxide Synthase β in the Macula Densa via Tubuloglomerular Feedback Response

(2019) Jin Wei et al.   HYPERTENSION

NaHCO 3 Dilates Mouse Afferent Arteriole Via Na + /HCO 3 − Cotransporters NBCs

(2019) Shan Jiang et al.   HYPERTENSION

Trimethylamine-N -oxide promotes brain aging and cognitive impairment in mice

(2018) Dang Li et al.   AGING CELL

Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease

(2018) Tiejun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic AneurysmNovelty and Significance

(2018) Surawee Chuaiphichai et al.   HYPERTENSION

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

The gut microbiota and blood pressure in experimental models

(2018) Hamdi A. Jama et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction

(2018) Sevtap Han et al.   VASCULAR PHARMACOLOGY

Fenofibrate improves vascular endothelial function and contractility in diabetic mice

(2018) Nan Xu et al.   Redox Biology

Beyond gut feelings: how the gut microbiota regulates blood pressure

(2017) Francine Z. Marques et al.   Nature Reviews Cardiology

Alterations in the gut microbiota can elicit hypertension in rats

(2017) Sareema Adnan et al.   PHYSIOLOGICAL GENOMICS

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular DysfunctionHighlights

(2016) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular DysfunctionClinical Perspective

(2016) Lei Wang et al.   CIRCULATION

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Global Disparities of Hypertension Prevalence and ControlClinical Perspective

(2016) Katherine T. Mills et al.   CIRCULATION

Hypertension-Linked Pathophysiological Alterations in the GutNovelty and Significance

(2016) Monica M. Santisteban et al.   CIRCULATION RESEARCH

Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2016) Susanne H. Karbach et al.   Journal of the American Heart Association

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Autoregulation in Health and Disease

(2015) Mattias Carlström et al.   PHYSIOLOGICAL REVIEWS

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-Activated Protein Kinase-α2 In Vivo

(2013) Bin Liang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential Control of Calcium Homeostasis and Vascular Reactivity by Ca 2+ /Calmodulin-Dependent Kinase II

(2013) Anand M. Prasad et al.   HYPERTENSION

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Lipid-Induced Endoplasmic Reticulum Stress in Liver Cells Results in Two Distinct Outcomes: Adaptation with Enhanced Insulin Signaling or Insulin Resistance

(2012) Caroline S. Achard et al.   ENDOCRINOLOGY

p47 phox Is Required for Afferent Arteriolar Contractile Responses to Angiotensin II and Perfusion Pressure in Mice

(2011) En Yin Lai et al.   HYPERTENSION

Tumor Progression Locus 2 Mediates Signal-Induced Increases in Cytoplasmic Calcium and Cell Migration

(2011) M. Hatziapostolou et al.   Science Signaling

Superoxide Dismutase 1 Limits Renal Microvascular Remodeling and Attenuates Arteriole and Blood Pressure Responses to Angiotensin II via Modulation of Nitric Oxide Bioavailability

(2010) Mattias Carlström et al.   HYPERTENSION

Involvement of calcium-calmodulin-dependent protein kinase II in endothelin receptor expression in rat cerebral arteries

(2009) Roya Waldsee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION