Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications

Induction and application of ferroptosis in cancer therapy

(2022) Qing Nie et al.   Cancer Cell International

Targeting Regulated Cell Death with Pharmacological Small Molecules: An Update on Autophagy-Dependent Cell Death, Ferroptosis, and Necroptosis in Cancer

(2022) Junhao Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

(2022) Chen Zhang et al.   Molecular Cancer

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT‑dependent ferroptosis pathway

(2022) Liyi Zhang et al.   Oncology Letters

Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis

(2022) Jingwei Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

What's next for AlphaFold and the AI protein-folding revolution

(2022) Ewen Callaway   NATURE

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Construction and validation of a ferroptosis-related long noncoding RNA signature in clear cell renal cell carcinoma

(2022) Zhenpeng Zhu et al.   Cancer Cell International

A novel pyroptosis-regulated gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinoma

(2022) Baozhu Zhang et al.   Frontiers in Molecular Biosciences

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

(2021) Yahui Ding et al.   Journal of Hematology & Oncology

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Regulation of Ferroptosis in Cancer

(2021) Min Ji Kim et al.   Biology-Basel

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Curcumin induces ferroptosis in non‐small‐cell lung cancer via activating autophagy

(2021) Xin Tang et al.   Thoracic Cancer

Cytochrome P450 reductase (POR) as a ferroptosis fuel

(2021) Pranavi Koppula et al.   Protein & Cell

Emerging mechanisms and targeted therapy of ferroptosis in cancer

(2021) Haiyan Wang et al.   MOLECULAR THERAPY

MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma

(2021) Yuxiong Lu et al.   Cell Death & Disease

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

(2021) Zheng Tang et al.   Clinical and Translational Medicine

Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma

(2021) Xiaopeng Zhu et al.   Aging-US

Recent progress on targeting ferroptosis for cancer therapy

(2021) Guangxiang Xu et al.   BIOCHEMICAL PHARMACOLOGY

Identification of the prognostic value of ferroptosis-related gene signature in breast cancer patients

(2021) Ding Wang et al.   BMC CANCER

A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma

(2021) Yingkai Hong et al.   BMC CANCER

Ferroptosis-related gene signature predicts the prognosis in Oral squamous cell carcinoma patients

(2021) Hongyu Li et al.   BMC CANCER

Ferroptosis‐related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma

(2021) Ting Lei et al.   CANCER SCIENCE

Development and validation of a novel ferroptosis-related gene signature for predicting prognosis and immune microenvironment in head and neck squamous cell carcinoma

(2021) Feinan He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IFNγ‐mediated repression of system xc − drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells

(2021) Rui Kong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer

(2021) Congjun Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

A Novel Ferroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Breast Cancer

(2021) Lizhe Zhu et al.   Frontiers in Cell and Developmental Biology

Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma

(2021) Xiao-Liang Xing et al.   Cancer Cell International

Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis

(2021) Haiwei Ni et al.   ENVIRONMENTAL TOXICOLOGY

Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism

(2021) Zhao Cui et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer

(2021) Yanfei Shao et al.   Oxidative Medicine and Cellular Longevity

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells

(2021) Yadong Sun et al.   Cell Death & Disease

Simvastatin induced ferroptosis for triple-negative breast cancer therapy

(2021) Xianxian Yao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Ferroptosis-Related Long Non-Coding RNA Signature Contributes to the Prediction of Prognosis Outcomes in Head and Neck Squamous Cell Carcinomas

(2021) Wenru Jiang et al.   Frontiers in Genetics

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

(2020) Yanwei Su et al.   CANCER LETTERS

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

(2020) Changfeng Li et al.   Autophagy

Ferroptosis at the crossroads of infection, aging and cancer

(2020) Shinya Toyokuni et al.   CANCER SCIENCE

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma

(2020) Zhong-jie Li et al.   ACTA PHARMACOLOGICA SINICA

Glutathione Synthesis in Cancer Cells

(2020) E. V. Kalinina et al.   BIOCHEMISTRY-MOSCOW

Tanshinone IIA induces ferroptosis in gastric cancer cells through p53 mediated-SLC7A11 down-regulation

(2020) Zhenhua Guan et al.   BIOSCIENCE REPORTS

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

(2020) Dominik C. Fuhrmann et al.   Redox Biology

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis

(2020) Xiaotian Xu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species

(2020) Shuai Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis

(2020) Zuli Wang et al.   MOLECULAR THERAPY

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

(2020) Jian-Shu Lou et al.   PHYTOMEDICINE

Oridonin induces ferroptosis by inhibiting gamma‐glutamyl cycle in TE1 cells

(2020) Junhong Zhang et al.   PHYTOTHERAPY RESEARCH

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway

(2020) Pengfei Liu et al.   Redox Biology

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Oxidative Damage and Antioxidant Defense in Ferroptosis

(2020) Feimei Kuang et al.   Frontiers in Cell and Developmental Biology

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells

(2020) Ruihua Li et al.   Oxidative Medicine and Cellular Longevity

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin

(2019) Somanathapura K. NaveenKumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

(2019) Guo-Qing Chen et al.   CELL DEATH AND DIFFERENTIATION

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

(2019) Evijola Llabani et al.   Nature Chemistry

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits bladder cancer cell growth via the mitochondrial apoptosis and JNK pathways

(2019) Qiyu Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells

(2019) William R. Taylor et al.   Scientific Reports

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells

(2019) Kang Wang et al.   Drug Design Development and Therapy

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

(2019) Xiaoqing Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advancing Drug Discovery via Artificial Intelligence

(2019) H.C. Stephen Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma

(2019) Ning Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology

(2019) Rinku Dutta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

(2019) Wen-Hsuan Yang et al.   MOLECULAR CANCER RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

(2019) Tzu-Chi Chen et al.   Redox Biology

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors

(2018) Shenglin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

(2018) Ling-Chu Chang et al.   CANCER LETTERS

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer

(2018) Eun Hye Kim et al.   CANCER LETTERS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron-dependent cell death as executioner of cancer stem cells

(2018) Bin Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

(2018) Heike Miess et al.   ONCOGENE

Haemin-induced cell death in human monocytic cells is consistent with ferroptosis

(2018) Shion Imoto et al.   TRANSFUSION AND APHERESIS SCIENCE

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

(2018) Gaofei Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Development of a novel FePt-based multifunctional ferroptosis agent for high-efficiency anticancer therapy

(2018) Ludan Yue et al.   Nanoscale

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

(2018) Andrea Scirè et al.   BIOFACTORS

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Erianin induces cell apoptosis through ERK pathway in human nasopharyngeal carcinoma

(2018) Yen-Tze Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel benzopyran derivatives and their therapeutic applications: a patent review (2009–2016)

(2017) Cheng Xiu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

(2017) Trang Thi Mai et al.   Nature Chemistry

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

(2017) Shumei Ma et al.   PLoS One

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

(2017) Farhan Basit et al.   Cell Death & Disease

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

(2016) Renyu Lin et al.   CANCER LETTERS

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Cisplatin resistance and opportunities for precision medicine

(2016) Lauren Amable   PHARMACOLOGICAL RESEARCH

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

(2016) S Ma et al.   Cell Death & Disease

Erianin induces G2/M-phase arrest, apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo

(2016) H Wang et al.   Cell Death & Disease

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

(2016) Tina Sehm et al.   Oncotarget

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

(2015) Ming-zhe Ma et al.   CANCER LETTERS

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

(2015) Jung Hoon Woo et al.   CELL

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2)

(2015) Mahmoud M. Elguindy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetaminophen: Old Drug, New Issues

(2015) Anita Aminoshariae et al.   JOURNAL OF ENDODONTICS

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

Ferroptosis is Involved in Acetaminophen Induced Cell Death

(2015) Tamás Lőrincz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

(2015) Edna Ooko et al.   PHYTOMEDICINE

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

(2015) Stephanie M. Robert et al.   Science Translational Medicine

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer

(2015) Sanjeev Krishna et al.   EBioMedicine

Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes

(2015) E. V. Kalinina et al.   BIOCHEMISTRY-MOSCOW

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Selenoproteins: Molecular Pathways and Physiological Roles

(2014) Vyacheslav M. Labunskyy et al.   PHYSIOLOGICAL REVIEWS

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Iron and Cancer Risk--A Systematic Review and Meta-analysis of the Epidemiological Evidence

(2013) A. Fonseca-Nunes et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

(2013) Shuang Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

(2013) Aniruddha Sengupta et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Identification of aldo-keto reductases as NRF2-target marker genes in human cells

(2013) Kyeong-Ah Jung et al.   TOXICOLOGY LETTERS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Ironing Out Cell Death Mechanisms

(2012) John C. Reed et al.   CELL

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione

(2012) Akhilesh Kumar et al.   EMBO REPORTS

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

(2012) Rainer Wilcken et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

(2011) Nobuhiko Harada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma

(2011) Weijie Guo et al.   CANCER LETTERS

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine

(2008) Jun Guan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

(2008) Scott M. Wilhelm et al.   MOLECULAR CANCER THERAPEUTICS