Article
Cell Biology
Dongsheng He, Shengyin Liao, Linlin Xiao, Lifang Cai, Mengxing You, Limei He, Weiming Huang
Summary: This study identified distinct ferroptosis-related genes in patients with HNSCC and constructed a prognostic risk model with high accuracy. The model was validated internally and externally, showing satisfactory predictive capacity. Furthermore, TMB was positively correlated with the risk score, and immune infiltration and immune checkpoint genes played significant roles in prognosis. The relationship between the model and drug sensitivity was also demonstrated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ruoyan Cao, Weilin Zhang, Hongjian Zhang, Lixuan Wang, Xijuan Chen, Xianyue Ren, Bin Cheng, Juan Xia
Summary: The peroxidase family of peroxiredoxins (PRDXs) plays a vital role in maintaining the intracellular balance of ROS in head and neck squamous cell carcinoma (HNSCC). The expression of PRDX1, PRDX4, and PRDX5 in HNSCC is increased, while the expression of PRDX2 is decreased. Higher expression of PRDX4/5/6 indicates poor prognosis, while lower expression of PRDX1/5 is associated with more immune cell infiltration, higher expression of immune-related molecules, and a likely response to anti-PD-1 treatment. Knockdown of PRDX5 inhibits HNSCC cell proliferation, invasion, and metastasis, and promotes apoptosis through its antioxidant property. This study highlights the potential role of PRDXs, particularly PRDX5, in HNSCC and suggests it as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Wei Lu, Yihua Wu, Shengyun Huang, Dongsheng Zhang
Summary: A four-gene prognostic signature based on ferroptosis was established to predict the prognosis of head and neck squamous cell carcinoma, providing a potential tool for personalized treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Yaodong He, Yunshan Li, Junwei Xiang, Xu Huang, Mingyu Zhao, Yuanyin Wang, Ran Chen
Summary: Tyrosine kinase 2 (TYK2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and is associated with tumor growth, prognosis, and immune infiltration. TYK2 can serve as a novel biomarker for assessing the prognosis of HNSCC patients and aiding in immunotherapy against HNSCC.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Wenying Zhu, Zhipeng Ye, Ling Chen, Haifeng Liang, Qian Cai
Summary: This study identified a potential clinical value of pyroptosis-related long non-coding RNAs in head and neck squamous cell carcinoma. The lncRNA signature consisting of 14 pyroptosis-related long non-coding RNAs could serve as a prognostic marker for HNSCC, suggesting pyroptosis as a promising therapeutic target in this type of cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Hao Chi, Puyu Jiang, Ke Xu, Yue Zhao, Bingyu Song, Gaoge Peng, Bingsheng He, Xin Liu, Zhijia Xia, Gang Tian
Summary: This study constructed a prognostic model for HNSCC using anoikis-related genes (ANRGs) and found differential immune status and drug sensitivity between high-risk and low-risk groups. In addition, through DCA analysis, the researchers demonstrated the potential clinical benefit of the model in the clinical practice.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Shixian Liu, Weiwei Liu, Zhao Ding, Xue Yang, Yuan Jiang, Yu Wu, Yehai Liu, Jing Wu
Summary: This study identified ten genes associated with HNSCC and established a risk score based on these genes. By constructing a diagnostic model, it was found that the high-risk group had higher sensitivity to common chemotherapeutic drugs. Additionally, the expression of DCLRE1C was higher in HNSCC tissues compared to normal tissues.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Genetics & Heredity
Qiwei Wang, Yinan Zhao, Fang Wang, Guolin Tan
Summary: This study identified hub genes significantly associated with immune-checkpoint blockade (ICB) and activated CD8(+) T-cell gene signatures, and constructed a novel immune signature named IMS. The high IMS group showed significant immune activation, better prognosis, and increased immunotherapy responsiveness. IMS potentially represents a candidate biomarker for ICB. Moreover, a higher IMS was associated with metabolic reprogramming and cellular crosstalk in the tumor microenvironment.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Hasan Baysal, Vasiliki Siozopoulou, Hannah Zaryouh, Christophe Hermans, Ho Wa Lau, Hilde Lambrechts, Erik Fransen, Ines De Pauw, Julie Jacobs, Marc Peeters, Patrick Pauwels, Jan Baptist Vermorken, Evelien Smits, Filip Lardon, Jorrit De Waele, An Wouters
Summary: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors with a poor prognosis. This study explored the immune signature and the interaction between HNSCC and the immune system. The results identified potential therapeutic targets and prognostic factors for HNSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Fang Chen, Xin Gong, Meng Xia, Feng Yu, Jian Wu, Chaosheng Yu, Junzheng Li
Summary: This study identifies aging-related risk signatures as a reliable prognostic model for predicting the survival of HNSCC patients and provides potential targets for improving outcomes of immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhi-Min Yang, Bing Liao, Si-Si Yang, Tong Su, Jing Zhang, Wei-Ming Wang
Summary: NEK6 is up-regulated in head and neck squamous cell carcinoma (HNSCC) and predicts poor prognosis. It is associated with immune cell infiltration and expression of immune checkpoints, potentially serving as a predictor for prognosis and response to immunotherapy in HNSCC patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Zeng-Hong Wu, Cheng Li, You-Jing Zhang, Wen Zhou
Summary: This study identifies key genes related to stemness in HNSCC by analyzing HNSCC mRNAsi data and gene interaction networks. The study reveals the critical role of these genes in HNSCC.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Junwei Xiang, Yaodong He, Yunshan Li, Kexuan Wu, Mengxiang Cheng, Yuanyin Wang, Ran Chen
Summary: In this study, a risk assessment model consisting of 14 hrlncRNA pairs was constructed for predicting and guiding the prognosis and treatment of HNSCC patients. High-risk patients had unfavorable prognosis and significant differences in TMB and tumor immune infiltration compared to the low-risk group. The model has potential clinical applications.
Article
Oncology
Dayang Chen, Mengmeng Wang, Ying Guo, Wei Wu, Xiang Ji, Xiaowen Dou, Huamei Tang, Zengyan Zong, Xiuming Zhang, Dan Xiong
Summary: The study developed a predictive methylation signature based on bioinformatics analysis to improve the prognosis and therapeutic outcome of patients with Head and neck squamous cell carcinoma (HNSCC). By identifying differentially methylated genes and sites, a risk score formula with five methylation sites was established for predicting overall survival. The innovative methylation signature-based model serves as a robust prognostic tool for guiding clinical therapy and predicting OS in HNSCC patients.
Article
Immunology
Zixuan Hu, Jiaying Zhou, Yupeng Li, Yizhao Luan, Huan Li, Bo Jia, Zhi Xie, Bin Cheng, Tong Wu
Summary: This study explored the relationship between peripheral immune signatures and the survival of head and neck squamous cell carcinoma (HNSCC) patients. The peripheral neutrophil-to-lymphocyte ratio (pNLR) was identified as a significant prognostic indicator. Analysis of tumor RNA-seq data further confirmed the association between high tissue NLR and poor prognosis, as well as the enrichment of immune-related genes in different prognostic groups. The correlation between peripheral immune signatures and the tumor immune microenvironment (TIME) was confirmed in an independent cohort. Overall, the findings suggest that pNLR is a feasible prognostic signature reflecting the TIME patterns in HNSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xiuxing Chen, Ziming Du, Mayan Huang, Deshen Wang, William Pat Fong, Jieying Liang, Lei Fan, Yun Wang, Hui Yang, Zhigang Chen, Mingtao Hu, Ruihua Xu, Yuhong Li
Summary: The study suggests that preoperative exosomal PD-L1 (exoPD-L1) and soluble PD-L1 (sPD-L1) levels are associated with the survival of colorectal liver metastasis patients, and are related to T cell infiltration at liver metastases. Tracking exoPD-L1 and sPD-L1 levels could help monitor disease status and detect early recurrence.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Zhi-gang Chen, Yun Wang, William Pat Fong, Ming-tao Hu, Jie-ying Liang, Lingyun Wang, Yu-hong Li
Summary: Utilizing a computational algorithm to estimate immune cell infiltration patterns, two ICI phenotypes were identified in PDAC patients, and an ICIscore was constructed to predict prognosis and chemotherapy benefit. The high ICIscore subtype was associated with immune-active signaling pathways and anti-tumor immunity, while the low ICIscore subtype was linked to tumor progressive signaling pathways. The ICIscore may serve as a prognostic biomarker for patients receiving immune checkpoint inhibitors in various cancer types, highlighting the relationship between the ICI environment and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Toxicology
Ting Zhan, Hao Xiong, Jiaqi Pang, Weijian Zhang, Yongyi Ye, Zhengrong Liang, Xiaotong Huang, Feinan He, Bingquan Jian, Wuhui He, Yiming Gao, Xin Min, Yiqing Zheng, Haidi Yang
Summary: This study demonstrates that modulation of NAD(+) biosynthesis can effectively prevent cisplatin-induced hearing loss by reducing hair cell loss and deformation through promoting SIRT1 activity, increasing mtDNA content, and enhancing AMPK expression, as well as suppressing PARP1 activity. This finding provides a new potential therapeutic approach for mitigating cisplatin ototoxicity.
TOXICOLOGY LETTERS
(2021)
Article
Cell Biology
Feinan He, Xiaotong Huang, Guokun Wei, Xiaorong Lin, Weijian Zhang, Wei Zhuang, Wuhui He, Ting Zhan, Hai Hu, Haidi Yang
Summary: This study explored the effect of ACSL4-catalyzed lipid peroxidation on cisplatin-induced hearing loss and found that inhibition of ACSL4 expression may be an effective preventive measure against cisplatin ototoxicity. Metabolomic assays revealed significant changes in metabolite levels, particularly in the glutathione metabolic pathway and the arachidonic acid metabolic pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Qiu-Yun Luo, Tian Di, Zhi-Gang Chen, Jian-Hong Peng, Jian Sun, Zeng-Fei Xia, Wen-Tao Pan, Fan Luo, Fei-Teng Lu, Yu-Ting Sun, Li-Qiong Yang, Lin Zhang, Miao-Zhen Qiu, Da-Jun Yang
Summary: This study identified genes regulating RNA splicing that are associated with survival in colon cancer and constructed a risk score model. The risk model showed good performance in predicting clinical prognosis and AKAP8L was found to play a role in promoting colon cancer progression.
Article
Oncology
Lei Wen, Zhigang Chen, Xiaomeng Ji, William Pat Fong, Qiong Shao, Chao Ren, Yanyu Cai, Binkui Li, Yunfei Yuan, Deshen Wang, Yuhong Li
Summary: CRLM patients with POLE EDM exhibit distinct clinical characteristics and extremely high TMB, and show significant clinical response to ICI-based combination therapy. Complete sequencing of POLE exonuclease domains is recommended in CRLM patients clinically.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Hematology
Yun Wang, Shuzhao Chen, Peidong Chi, Runcong Nie, Robert Peter Gale, Hanying Huang, Zhigang Chen, Yanyu Cai, Enping Yan, Xinmei Zhang, Na Zhong, Yang Liang
Summary: In this study, we developed an eight-gene signature related to T-cell function using the random survival forest algorithm to predict the survival rate of acute myeloid leukemia (AML) patients. The signature showed good predictive accuracy in the training and validation cohorts, and it independently predicted the survival period of patients. Further analysis revealed that the genes in the high-risk group were mainly associated with immune suppression pathways. Combining the gene expression signature with the existing AML prognosis models significantly improved the accuracy of survival prediction.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Liu-Fang Ye, Zi-Yao Huang, Xiao-Xi Chen, Zhi-Gang Chen, Si-Xian Wu, Chao Ren, Ming-Tao Hu, Hua Bao, Ying Jin, Feng Wang, Feng-Hua Wang, Zi-Ming Du, Xue Wu, Huai-Qiang Ju, Yang Shao, Yu-Hong Li, Rui-Hua Xu, De-Shen Wang
Summary: This study aimed to identify mechanisms of drug resistance to the combination of vemurafenib, irinotecan, and cetuximab (VIC) in BRAFV600E metastatic colorectal cancer (mCRC). The results showed that BRAF mutant in baseline plasma and its dynamics are significantly associated with VIC-related response, and concurrent RNF43 mutation significantly sensitises tumour to VIC treatment. VIC resistance frequently involves genes in PI3K, MAPK pathway, and several novel resistance mechanisms such as TGFBR2 and SMAD4 mutations. Additionally, acquired altered genes in DNA damaging repair pathway were identified in 33% of patients after VIC treatment, and these patients with pre-treatment resistance subclones developed inferior responses, along with higher tumour mutation burden both at baseline and progression plasma.
DRUG RESISTANCE UPDATES
(2022)
Article
Immunology
Mingtao Hu, Zhigang Chen, Dandan Hu, Shaoyan Xi, Deshen Wang, Xiaolong Zhang, William Pat Fong, Lei Wen, Yanyu Cai, Yunfei Yuan, Binkui Li, Xiaojun Wu, Zhenhai Lu, Gong Chen, Liren Li, Peirong Ding, Zhizhong Pan, Desen Wan, Ziming Du, Minshan Chen, Yuhong Li
Summary: The study found that HGPs of colorectal cancer liver metastases have distinct molecular characteristics and are enriched in different signaling pathways. The morphological changes of HGPs are the combined effect of the heterogeneity and remodeling of primary tumors seeds and liver soils.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Tian Di, Yue-rong Lai, Qiu-yun Luo, Zhi-gang Chen, Yong Du, Run-duan Lin, Li-qiong Yang, Lin Zhang, Jian Sun
Summary: This study aimed to develop a prognostic nomogram for gastric cancer patients based on the levels of PD-L1 and CEA. The nomogram divided the patients into three risk groups, and PD-L1 and CEA levels were found to be independent predictors for progression-free survival and overall survival of patients with gastric cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
De-Shen Wang, Hui Yang, Xiao-Yun Liu, Zhi-Gang Chen, Yun Wang, William Pat Fong, Ming-Tao Hu, Yuan-Chao Zheng, Yun Zheng, Bin-Kui Li, Yun-Fei Yuan, Gong Chen, Zhi-Zhong Pan, Lele Song, Yu-Hong Li, Rui-Hua Xu
Summary: This study found that ctDNA analysis can be used to predict the prognosis of patients undergoing resection of CRLM. Patients with a higher baseline ctDNA variant allele frequency represent a higher tumor burden, while decreased ctDNA during pre-operative chemotherapy predicted better tumor response. Patients with detectable ctDNA post-operatively and after adjuvant chemotherapy were associated with significantly shorter recurrence-free survival.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
