Article
Genetics & Heredity
Jiecheng Ye, Yining Wu, Heyuan Cai, Li Sun, Wanying Deng, Ruikun Liang, Anjia Han
Summary: A study identified and verified a 10-FRG prognostic signature and nomogram for ESCC, which successfully stratified patients into high-risk and low-risk groups. The nomogram demonstrated better predictive power when combined with clinical predictors, compared to using risk score or clinical variables alone. Functional analysis revealed the 10-FRG signature's association with ferroptosis, differentiation, and immune response, providing potential therapeutic targets for ESCC.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Dongsheng He, Shengyin Liao, Linlin Xiao, Lifang Cai, Mengxing You, Limei He, Weiming Huang
Summary: This study identified distinct ferroptosis-related genes in patients with HNSCC and constructed a prognostic risk model with high accuracy. The model was validated internally and externally, showing satisfactory predictive capacity. Furthermore, TMB was positively correlated with the risk score, and immune infiltration and immune checkpoint genes played significant roles in prognosis. The relationship between the model and drug sensitivity was also demonstrated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Muyuan Liu, Litian Tong, Bin Liang, Xuhong Song, Lingzhu Xie, Hanwei Peng, Dongyang Huang
Summary: Our study successfully established a novel 15-mRNA prognostic model for predicting overall survival of non-distant metastatic OTSCC. The prediction ability of this 15-gene signature was independent of other clinicopathological factors and demonstrated excellent prediction accuracy. Additionally, an external validation using the GEO dataset confirmed the good prediction ability of the 15-gene model. The prognostic nomogram integrating the 15-gene signature and clinicopathological factors has the potential to be developed as a prognostic tool.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiahang Song, Yanhu Liu, Xiang Guan, Xun Zhang, Wenda Yu, Qingguo Li
Summary: This study focused on evaluating the association between ferroptosis-related gene expression profiles and prognosis in ESCC patients, developing a new ferroptosis-related gene signature that accurately classified patients with diverse survival outcomes in GEO and TCGA cohorts. The signature was identified as an independent predictor of ESCC risk and showed potential clinical application for predicting prognosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Shuqin Wang, Sien Zhang, Zhi Lin, Jingxin Ma, Lijun Zhu, Guiqing Liao
Summary: In this study, an apoptosis-related gene (ARG) prediction model was established to predict the survival rate of oral squamous cell carcinoma (OSCC) patients. The model showed good prognostic ability and a nomogram was built to forecast the survival probability of OSCC patients. GO and KEGG analyses revealed multiple molecular biological processes and signaling pathways associated with this prognostic model in OSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhenlei Fan, Tao Liu, Hanfei Huang, Jie Lin, Zhong Zeng
Summary: A study identified a ferroptosis-related gene signature as a potential prognostic biomarker for predicting graft loss in allogeneic kidney transplantation. The gene signature showed independent predictive value for graft loss and could contribute to improving transplantation outcomes. Immune-related and cytokine signaling pathways were enriched in patients with poor outcomes, highlighting the significance of the gene signature in predicting transplant success.
Article
Genetics & Heredity
Tao Li, Yi Wang, Xianwang Xiang, Chuanjun Chen
Summary: This study constructed a prognostic model for oral squamous cell carcinoma (OSCC) patients based on 8 ferroptosis-related lncRNAs, which were co-expressed with 25 mRNAs. The model can be used for prognostic evaluation and immune analysis of OSCC patients, and provides a new direction for targeted therapy in OSCC.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Min Deng, Shiquan Sun, Rongce Zhao, Renguo Guan, Zhen Zhang, Shaohua Li, Wei Wei, Rongping Guo
Summary: This study investigates the expression levels of pyroptosis-related genes in hepatocellular carcinoma (HCC) and their relationship with prognosis. A 10-gene signature was constructed to classify HCC patients into low-risk and high-risk groups, and the results showed that the low-risk group had significantly better survival rates. PRGs play a significant role in tumor immunity and have the potential to predict the prognosis of HCC patients.
MOLECULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Xin-Yuan Zhang, Shang Xie, Dian-Can Wang, Xiao-Feng Shan, Zhi-Gang Cai
Summary: This study aimed to investigate the prognosis of postoperative OSCC patients, establish a nomogram survival prediction model, and verify its effectiveness.
Article
Oncology
Qi Wang, Yaokun Chen, Wen Gao, Hui Feng, Biyuan Zhang, Haiji Wang, Haijun Lu, Ye Tan, Yinying Dong, Mingjin Xu
Summary: A prognostic signature related to ferroptosis was identified to assess the prognosis and immunotherapy efficacy of lung squamous cell carcinoma (LUSC) patients. The research findings provide guidance for individualized treatment decisions for LUSC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Siteng Chen, Encheng Zhang, Tuanjie Guo, Jialiang Shao, Tao Wang, Ning Zhang, Xiang Wang, Junhua Zheng
Summary: We developed and validated a prognostic marker based on ferroptosis-related gene (FRG) for patients with clear cell renal cell carcinoma (ccRCC). This marker can act as a risk factor and aid in updating the tumor staging system. Cell cycle-related pathways may be involved in the regulation of ccRCC through ferroptosis.
Article
Genetics & Heredity
Wei Lu, Yihua Wu, Shengyun Huang, Dongsheng Zhang
Summary: A four-gene prognostic signature based on ferroptosis was established to predict the prognosis of head and neck squamous cell carcinoma, providing a potential tool for personalized treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Lijun Yu, Zhenwei Gao, Zeyu Li, Ping Liu, Ya Gao, Gang Liang
Summary: This study investigates the molecular characteristics of cervical squamous cell carcinoma (CESC) and predicts prognosis by analyzing ferroptosis-related gene (FRG) expression data. It identifies 21 FRGs associated with CESC prognosis and stratifies patients into different subtypes based on these genes, showing differences in prognosis, immune cell types, and immune checkpoint expression. A risk model based on FRG methylation levels is constructed and validated, highlighting its potential role in predicting CESC prognosis and assessing immune responses in patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yujie Shen, Qiang Huang, Yifan Zhang, Chi-Yao Hsueh, Liang Zhou
Summary: This study identified differentially expressed MRGs related to LSCC prognosis and constructed a prognostic signature based on two MRGs (GPT and SMS), which was validated internally and externally. The prognostic signature was shown to be an independent risk factor for LSCC and a nomogram based on this signature was developed for clinical application.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Yanjie Shuai, Yuansheng Duan, Mengqian Zhou, Kai Yue, Dandan Liu, Yan Fang, Yuxuan Wang, Yansheng Wu, Ze Zhang, Xudong Wang
Summary: The study developed a prognostic nomogram for patients with oral squamous cell carcinoma based on immunohistochemistry biomarkers, stratifying patients into high- and low-risk groups, and demonstrated its effectiveness through survival analysis.