Article
Oncology
Anhui Yang, Zhen Sun, Rui Liu, Xin Liu, Yue Zhang, Yulin Zhou, Ye Qiu, Xinrui Zhang
Summary: The novel ERN-loaded tumor-targeting nanoparticles showed excellent anti-liver cancer activity in vivo and in vitro by inducing cellular apoptosis, exhibiting immunoregulatory actions, and targeting tumor tissues more effectively than free ERN and LP-ERN nanoparticles. These results suggest that a Tf-conjugated LP ERN-delivery system may have clinical utility for the treatment of liver cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Renba Liang, Xiaodong Zhu
Summary: UC2288 inhibited the growth of NPC by suppressing the EGFR/ERK pathway and may be a promising therapeutic option for NPC.
Article
Chemistry, Medicinal
Hui-qiong Zhang, Xiao-fang Xie, Gang-min Li, Jun-ren Chen, Meng-ting Li, Xin Xu, Qiu-yun Xiong, Guan-ru Chen, Yan-peng Yin, Fu Peng, Yan Chen, Cheng Peng
Summary: Erianin, a small-molecule compound isolated from Dendrobium chrysotoxum Lindl, demonstrates evident antitumor activity in lung cancer cells by inhibiting cell growth and inducing apoptosis and cell cycle arrest through the PI3K/Akt/mTOR pathway. Additionally, in a mouse xenograft model, Erianin shows promise as a potential treatment for lung cancer by inhibiting tumor growth and enhancing immune function.
PHYTOTHERAPY RESEARCH
(2021)
Review
Cell Biology
Reiko Sugiura, Ryosuke Satoh, Teruaki Takasaki
Summary: The RAF/MEK/ERK signaling pathway regulates various cellular processes and its activation is linked to cell proliferation and cancer. Further research on the mechanisms of ERK activation is essential for developing effective cancer treatments.
Article
Biochemistry & Molecular Biology
Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Picrasidine I exerts anticancer effects in nasopharyngeal carcinoma by modulating HO-1 via the ERK and Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jian Lv, Ze Wang, Hongchao Liu
Summary: This study demonstrates that Erianin can effectively suppress lung cancer stemness through ferroptosis. It suggests that Erianin could be a valuable chemotherapeutic enhancer for lung cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Qingqiong Luo, Xiaoyan Li, Guifang Gan, Meng Yang, Xu Chen, Fuxiang Chen
Summary: The study revealed that erianin inhibits the growth of oral squamous cell carcinoma cells through inducing apoptosis and pyroptosis while also affecting autophagy. Additionally, erianin’s suppression of PPT1 and mTOR signaling pathways contributes to its antitumor effect in OSCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ming-Chang Hsieh, Yu-Sheng Lo, Yi-Ching Chuang, Chia-Chieh Lin, Hsin-Yu Ho, Ming-Ju Hsieh, Jen-Tsun Lin
Summary: Dehydrocrenatidine (DC), a beta-carboline alkaloid found in a shrub native to southern Asia, has been shown to significantly reduce the viability of human nasopharyngeal carcinoma (NPC) cells by inducing apoptosis through multiple pathways. This study suggests that targeting NPC cell lines with DC may be a promising strategy for NPC treatment in the future.
Article
Endocrinology & Metabolism
Yi Liu, Xiaobao Qian, Dandan Li, Zhensheng Qin
Summary: This study demonstrates that Erianin can suppress the growth of colorectal cancer cells by inducing cuproptosis. Erianin may induce ferroptosis by increasing the expression of FDX1 and protein lipoylation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
I. Gusti Md Gde Surya C. Trapika, Xin Tracy Liu, Long Hoa Chung, Felcia Lai, Chanlu Xie, Yang Zhao, Shaohui Cui, Jinbiao Chen, Collin Tran, Qian Wang, Shubiao Zhang, Anthony S. Don, George Qian Li, Jane R. Hanrahan, Yanfei Qi
Summary: Prostate cancer is the second most prevalent malignancy worldwide, thus novel treatments are urgently needed. Research shows that erianin exhibits anti-tumor effects in both androgen-sensitive and castration-resistant prostate cancer cells through different mechanisms.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Gangmin Li, Huiqiong Zhang, Hui Lai, Gang Liang, Jiang Huang, Fulan Zhao, Xiaofang Xie, Cheng Peng
Summary: Erianin, a major active component of Dendrobll caulis, exhibits various pharmacological effects including anti-tumor, anti-inflammatory, anti-diabetic retinopathy, anti-psoriasis, and antibacterial effects. However, its poor solubility and bioavailability limit its development and application. Therefore, it is essential to explore its extensive pharmacological effects and mechanisms, elucidate its pharmacokinetics, and synthesize its derivatives.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qun Miao, Wei-qing Deng, Wen-yu Lyu, Zhi-ting Sun, Shu-ran Fan, Ming Qi, Sheng-hui Qiu, Yin-ru Zhu, Jia-peng Lin, Min-feng Chen, Li-juan Deng
Summary: Colorectal cancer (CRC) is the third most common cause of cancer mortality worldwide. Approximately 40% of CRC patients have KRAS sequence variation, including KRAS G13D mutation (KRASG13D) CRC patients, who show little benefit from anti-EGFR therapy. Thus, there is an urgent need for new and effective anticancer agents in patients with KRASG13D CRC.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Medicinal
Yawen Yang, Qingqing Liu, Xinyi Wang, Shaohua Gou
Summary: In this study, multi-target HDAC inhibitors based on erianin and amino erianin were designed by introducing dominant structures of natural products. Two representative compounds showed good inhibitory effect against five cancer cells with strong HDAC inhibition and low toxicity toward normal cells. They were found to promote the generation of reactive oxygen species, cause DNA damage, block the cell cycle, and activate the apoptotic pathway, which are significant for the discovery of new HDAC inhibitors.
Article
Biochemistry & Molecular Biology
Lili Yan, Zhen Zhang, Yanfen Liu, Shuyi Ren, Zhiyu Zhu, Lu Wei, Jiao Feng, Ting Duan, Xueni Sun, Tian Xie, Xinbing Sui
Summary: This study systematically reviewed the anticancer activity and pharmacological mechanisms of Erianin, predicted the potential therapeutic targets and signaling pathways it might act on in cancer, and provided in silico ADMET properties of Erianin.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wen-Yong Gao, Chantana Boonyarat, Pitchayakarn Takomthong, Kusawadee Plekratoke, Yoshihiro Hayakawa, Chavi Yenjai, Rawiwun Kaewamatawong, Suchada Chaiwiwatrakul, Pornthip Waiwut
Summary: This study investigates the potential of acridone alkaloids in inhibiting cancer cell proliferation, particularly focusing on buxifoliadine E. The results indicate that buxifoliadine E shows significant cytotoxicity against prostate cancer, neuroblastoma, hepatoblastoma, and colorectal cancer cells. Western blotting analysis reveals changes in signaling protein expression, specifically Bid, cleaved caspase-3, and Bax, through the MAPKs pathway. Additionally, the study confirms the binding interaction between buxifoliadine E and Erk, resulting in the suppression of cancer cell proliferation.
Article
Multidisciplinary Sciences
Yen-Tze Liu, June Han Lee, Min Kuang Tsai, James Cheng-Chung Wei, Chi-Pang Wen
Summary: Moderate drinking is considered to have protective effects against certain diseases, but in most cases, alcohol worsens health conditions, especially when consumed at high risk levels. This study aims to balance the risks and benefits of moderate drinking and finds that it can prolong lifespan, while excessive drinking shortens lifespan. The combination of drinking and smoking further increases health risks, and moderate drinkers may also have an increased risk of oral and esophageal cancer.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Wan-Ting Tsai, Chun-Min Chen, Ming-Cheng Chung, Pei-Yu Tsai, Yen-Tzu Liu, Feng-Cheng Tang, Ying-Li Lin
Summary: This study aimed to determine the factors that influence the willingness to participate in ACP among outpatients in Taiwan. Factors such as being happy and being a healthcare professional were positively correlated with ACP participation, while a lack of ACP knowledge, valuing reducing families' end-of-life decision-making burden, and a belief in a good death were the main factors affecting subjects' willingness to participate in ACP.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Mu-Kuei Shieu, Hsin-Yu Ho, Shu-Hui Lin, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: KMT2C SNP rs4725443 is a potential genetic marker for oral cancer patients, associated with increased risk of oral cancer, advanced tumor stage, and poor cell differentiation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Medicinal
Bharath Kumar Velmurugan, Ming-Ju Hsieh, Chia-Chieh Lin, Hsin-Yu Ho, Ming-Chang Hsieh
Summary: This study evaluated the anticancer potential of a plant-based alkaloid called dehydrocrenatidine in human liver cancer cells. Dehydrocrenatidine was found to reduce cancer cell viability by regulating the cell cycle and activating apoptotic pathways.
Article
Environmental Sciences
Ming-Hong Hsieh, Yi-Liang Wu, Thomas Chang-Yao Tsao, Yi-Wen Huang, Jian-Cheng Lin, Chia-Yi Lee, Ming-Ju Hsieh, Shun-Fa Yang
Summary: The study aimed to evaluate the combined effect of GAS5 SNP and EGFR phenotypes on the clinicopathological characteristics of lung adenocarcinoma. The results showed that GAS5 SNP rs145204276 variant was associated with tumor stage, lymph node metastasis, and distal metastases in patients with EGFR wild type lung adenocarcinoma.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Jen-Tsun Lin, Yi-Ching Chuang, Mu-Kuan Chen, Yu-Sheng Lo, Chia-Chieh Lin, Hsin-Yu Ho, Yen-Tze Liu, Ming-Ju Hsieh
Summary: This article investigated the effects of a phytochemical called Shuterin on the proliferation and activity of NK cells. The study found that Shuterin enhanced the proliferation and cytotoxicity of NK cells, and induced the expression of certain proteins and the secretion of interferon. Therefore, Shuterin represents a promising agent for promoting the immune therapy of NK cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hui-Ju Yang, Bharath Kumar Velmurugan, Mu-Kuan Chen, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Hsin-Yu Ho, Ming-Ju Hsieh, Jiunn-Liang Ko
Summary: This study investigated the anticancer efficacy of a major paclitaxel metabolite called 7-Epitaxol in cisplatin-resistant HNSCC and found that it exhibits cytotoxic effects by inducing cell cycle arrest and apoptotic pathways. The study also revealed that 7-Epitaxol can suppress AKT and MAPK signaling pathways to induce cancer cell apoptosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Hsuan-Chih Tsai, Jing-Yang Huang, Ming-Yu Hsieh, Bing-Yen Wang
Summary: Lung cancer is a significant threat to the modern world, and this study investigated the overall survival of lung cancer patients based on histopathology in Taiwan from 2010 to 2016. The research found that adenocarcinoma showed the highest increase in overall survival, mainly due to the introduction of targeted therapy. Selecting the appropriate targeted therapy and accurately determining the histopathology of lung cancer are crucial for improving overall survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Mu-Kuei Shieu, Hsin-Yu Ho, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: This study demonstrated the antimetastatic effects of narciclasine in oral cancer and identified the underlying molecular mechanisms. Narciclasine inhibits oral cancer metastasis by regulating the ERK pathway and CTSB, providing potential targets for oral cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Pei-Ju Huang, Yun-Wen Chen, Tsai-Hung Yen, Yen-Tze Liu, Shih-Ping Lin, Hsin-Hua Chen
Summary: Using the electronic medical-record management system (EMRMS), we investigated the changes in disease activity of ankylosing spondylitis (AS) individuals before, during, and after the COVID-19 wave in Taiwan. We collected data on three disease activity measures (BASDAI, ASDAS-ESR, and ASDAS-CRP) from 126 AS individuals during different phases. The results showed that disease activity worsened after the COVID-19 wave, with higher levels of CRP, ESR, ASDAS-ESR, and ASDAS-CRP.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Chun-Yu Hsieh, Chia-Yen Lin, Shian-Shiang Wang, Ying-Erh Chou, Ming-Hsien Chien, Yu-Ching Wen, Ming-Ju Hsieh, Shun-Fa Yang
Summary: This study aimed to investigate the relationship between TIMP3 genetic polymorphisms and biochemical recurrence and clinicopathological features of prostate cancer. It was found that the TIMP3 rs9619311 genetic polymorphism was significantly associated with susceptibility to biochemical recurrence of prostate cancer. Moreover, in patients with a PSA concentration under 7 ng/mL, the TIMP3 rs9619311 genetic polymorphism was associated with Gleason total score upgrade and grade group upgrade.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Ming-Ju Hsieh, Hsin-Yu Ho, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mosleh Mohammad Abomughaid, Ming-Chang Hsieh, Mu-Kuan Chen
Summary: The study investigates the anticancer activities of a natural compound called semilicoisoflavone B (SFB) in oral squamous cell carcinoma (OSCC). Results show that SFB reduces cell viability by targeting the cell cycle and inducing apoptosis. It also inhibits several signaling pathways and downregulates survivin expression. Overall, the study suggests that SFB has potential as a therapeutic agent for human OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Chih-Hsiang Chiang, Yu-Jun Chang, Sin-Ru He, Jih-Ning Chao, Chih-Huai Yang, Yen-Tze Liu
Summary: This study aimed to investigate the relationship between vitamin D levels, metabolic factors, and colorectal polyps (CRPs). The results showed that vitamin D deficiency was significantly associated with the risk of CRPs, especially in adults over 50 years old and women.
Article
Multidisciplinary Sciences
Pei-Ju Huang, Yi-Hsing Chen, Wen-Nan Huang, Yi-Ming Chen, Kuo-Lung Lai, Tsu-Yi Hsieh, Wei-Ting Hung, Ching-Tsai Lin, Chih-Wei Tseng, Kuo-Tung Tang, Yin-Yi Chou, Yi-Da Wu, Chin-Yin Huang, Chia-Wei Hsieh, Yen-Ju Chen, Yu-Wan Liao, Yen-Tze Liu, Hsin-Hua Chen
Summary: This study investigated the impact of an electronic medical record management system (EMRMS) on disease activity and frequency of outpatient visits in patients with ankylosing spondylitis (AS). The results showed that the use of EMRMS increased the number of annual outpatient visits among AS patients with high disease activity but reduced the visit time for those with inactive disease. Continual assessments using the Ankylosing Spondylitis Disease Activity Score (ASDAS) may help control disease activity in AS patients.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)