Emerging mechanisms and targeted therapy of ferroptosis in cancer

The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity

(2021) Jia Song et al.   EMBO REPORTS

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

(2020) Enyong Dai et al.   Autophagy

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

(2020) Massimo M. Santoro   Cell Metabolism

Maillard reaction products with furan ring, like furosine, cause kidney injury through triggering ferroptosis pathway

(2020) Huiying Li et al.   FOOD CHEMISTRY

MicroRNA‐214‐3p enhances erastin‐induced ferroptosis by targeting ATF4 in hepatoma cells

(2020) Tao Bai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

(2020) Yuqing Wu et al.   Molecular Cancer

Ferroptosis‐Suppressor‐Protein 1: A Potential Neuroprotective Target for Combating Ferroptosis

(2020) Leilei Chen et al.   MOVEMENT DISORDERS

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway

(2020) Yanfeng Liu et al.   Nature Communications

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

(2020) Ji Cao et al.   Nature Communications

Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

(2020) Yishu Wang et al.   FEBS Open Bio

Ferroptosis in Cancer Cell Biology

(2020) Christina M. Bebber et al.   Cancers

Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis

(2020) Chang Li et al.   Cancer Cell International

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Inhibition of Ferroptosis Attenuates Acute Kidney Injury in Rats with Severe Acute Pancreatitis

(2020) Deliang Ma et al.   DIGESTIVE DISEASES AND SCIENCES

Iron: The cancer connection

(2020) Suzy V. Torti et al.   MOLECULAR ASPECTS OF MEDICINE

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

Time Course of Changes in Sorafenib‐Treated Hepatocellular Carcinoma Cells Suggests Involvement of Phospho‐Regulated Signaling in Ferroptosis Induction

(2020) Emily G. Werth et al.   PROTEOMICS

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells

(2020) Chen-Cheng Xue et al.   Science Advances

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy

(2020) Bo Yu et al.   Nature Communications

The Role of HIF in Immunity and Inflammation

(2020) Anne F. McGettrick et al.   Cell Metabolism

Statins as anti-cancer agents in the era of precision medicine

(2020) Joseph Longo et al.   CLINICAL CANCER RESEARCH

A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis

(2020) Zuli Wang et al.   MOLECULAR THERAPY

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

A Phase I Trial of Trametinib in Combination with Sorafenib in Patients with Advanced Hepatocellular Cancer

(2020) Richard Kim et al.   ONCOLOGIST

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

(2020) Youbo Zhao et al.   Cell Reports

ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway

(2020) Junru Chen et al.   CANCER LETTERS

On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease

(2019) Lin Cong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

(2019) Jennifer Yinuo Cao et al.   Cell Reports

Ferroptosis: Yet Another Way to Die

(2019) Kemal Kazan et al.   TRENDS IN PLANT SCIENCE

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

Ferroptosis and Brain Injury

(2019) Leslie Magtanong et al.   DEVELOPMENTAL NEUROSCIENCE

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

The release and activity of HMGB1 in ferroptosis

(2019) Qirong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell–cell contacts protect against t-BuOOH-induced cellular damage and ferroptosis in vitro

(2019) Christine Wenz et al.   ARCHIVES OF TOXICOLOGY

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

DUBbing Ferroptosis in Cancer Cells

(2019) Boyi Gan   CANCER RESEARCH

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

(2019) Guo-Qing Chen et al.   CELL DEATH AND DIFFERENTIATION

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

(2019) Yufei Wang et al.   EMBO REPORTS

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

(2019) Evijola Llabani et al.   Nature Chemistry

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

(2019) Shiyao Sui et al.   Cell Death & Disease

miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis

(2019) Feng-Jun Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses

(2019) Boutaina Daher et al.   CANCER RESEARCH

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Ferroptosis is governed by differential regulation of transcription in liver cancer

(2019) Xiao Zhang et al.   Redox Biology

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma

(2019) Yuanyang Lai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management

(2019) Varune Rohan Ramnarine et al.   EUROPEAN UROLOGY

Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

(2019) Yibing Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

(2019) Gloria E. Villalpando-Rodriguez et al.   Oxidative Medicine and Cellular Longevity

Redox-dependent gating of VDAC by mitoNEET

(2019) Colin H. Lipper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2

(2019) Xiao Xiao et al.   Molecular Brain

Identification and Functional Verification of MicroRNA-16 Family Targeting Intestinal Divalent Metal Transporter 1 (DMT1) in vitro and in vivo

(2019) Shuxia Jiang et al.   Frontiers in Physiology

Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia

(2019) Zan Li et al.   Redox Biology

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells

(2019) Zili Zhang et al.   Autophagy

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

(2019) Mengyu Yu et al.   CANCER SCIENCE

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

(2019) Jiajun Zhu et al.   Cell Metabolism

Ferroptosis and kidney diseases

(2019) Shumei Tang et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Emerging Role of Ferroptosis in Acute Kidney Injury

(2019) Zhaoxin Hu et al.   Oxidative Medicine and Cellular Longevity

Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research

(2019) Aikseng Ooi   SEMINARS IN CANCER BIOLOGY

Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers

(2019) Ahmed Gomaa et al.   Scientific Reports

LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells

(2019) Wenchuan Qi et al.   Scientific Reports

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Prominin-2 Suppresses Ferroptosis Sensitivity

(2019) Alexia Belavgeni et al.   DEVELOPMENTAL CELL

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

Caveolin-1 dictates ferroptosis in the execution of acute immune-mediated hepatic damage by attenuating nitrogen stress

(2019) Guanghui Deng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia

(2019) Heng Zhang et al.   Redox Biology

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Emerging Strategies of Cancer Therapy Based on Ferroptosis

(2018) Zheyu Shen et al.   ADVANCED MATERIALS

NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer

(2018) Ron Mittler et al.   ANTIOXIDANTS & REDOX SIGNALING

ROS Promotes Cancer Cell Survival through Calcium Signaling

(2018) Colleen R. Reczek et al.   CANCER CELL

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

(2018) Ling-Chu Chang et al.   CANCER LETTERS

Circular RNAs (circRNAs) in cancer

(2018) Ruoyu Zhou et al.   CANCER LETTERS

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

(2018) Gillian Douglas et al.   CARDIOVASCULAR RESEARCH

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

(2018) Young-Sun Lee et al.   MOLECULAR CANCER RESEARCH

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

(2018) Heike Miess et al.   ONCOGENE

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma

(2018) Nataliya Rohr-Udilova et al.   Oncotarget

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

(2018) Mami Sato et al.   Scientific Reports

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Selenium-Encoded Isotopic Signature Targeted Profiling

(2018) Jinjun Gao et al.   ACS Central Science

Iron and Cancer

(2018) Suzy V. Torti et al.   Annual Review of Nutrition

Histone Modifications: Insights into Their Influence on Gene Expression

(2018) Bruce Stillman   CELL

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Role of ferroptosis in hepatocellular carcinoma

(2018) Jianhua Nie et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma

(2018) Kexin Zhang et al.   MOLECULAR CARCINOGENESIS

Microenvironmental cues in cancer stemness

(2018) D. J. Flanagan et al.   NATURE CELL BIOLOGY

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Amino acid transporters revisited: New views in health and disease

(2018) Palanivel Kandasamy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

(2018) Zheyu Shen et al.   ACS Nano

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

(2018) Shuaifei Wang et al.   ACS Nano

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

The transferrin receptor: the cellular iron gate

(2017) Elena Gammella et al.   Metallomics

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

(2017) Sofie Martens et al.   Cell Death & Disease

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

(2017) Farhan Basit et al.   Cell Death & Disease

EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes

(2017) Yiqun Jiang et al.   Theranostics

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

FANCD2 protects against bone marrow injury from ferroptosis

(2016) Xinxin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antiferroptotic activity of non-oxidative dopamine

(2016) Ding Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

(2016) Jong-Lyel Roh et al.   CANCER LETTERS

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

(2016) Renyu Lin et al.   CANCER LETTERS

Emerging roles for lipids in non-apoptotic cell death

(2016) L Magtanong et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib

(2016) Aline Houessinon et al.   Molecular Cancer

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

(2016) S Ma et al.   Cell Death & Disease

Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys

(2016) Eun Ji Jang et al.   Oncotarget

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

(2016) Masanori Hasegawa et al.   Oncotarget

Editorial: Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes

(2016) Angel Catalá et al.   Frontiers in Physiology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

An important role of the hepcidin–ferroportin signaling in affecting tumor growth and metastasis

(2015) Wenli Guo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Enhancement of melphalan activity by buthionine sulfoximine and electroporation in melanoma cells

(2015) Alessia Ongaro et al.   ANTI-CANCER DRUGS

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

(2015) Jung Hoon Woo et al.   CELL

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion

(2015) L Sleire et al.   ONCOGENE

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

(2015) Huiqin Zhong et al.   Redox Biology

Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity

(2015) Manuela Schneider et al.   NEOPLASIA

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Caspase-Independent Cell Death Is Involved in the Negative Effect of EGF Receptor Inhibitors on Cisplatin in Non-Small Cell Lung Cancer Cells

(2013) H. Yamaguchi et al.   CLINICAL CANCER RESEARCH

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke

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Glutamine and cancer: cell biology, physiology, and clinical opportunities

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