Review
Medicine, Research & Experimental
Jinge Dou, Xiaowei Liu, Lei Yang, Dingming Huang, Xuelian Tan
Summary: Ferroptosis is a newly discovered form of regulated cell death and is closely related to various inflammatory diseases. Inflammatory microenvironments can regulate ferroptosis through metabolic changes or the secretion of related substances, and ferroptotic cells can recruit immune cells by releasing injury-related molecular patterns to induce the generation of inflammatory microenvironments.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Zhiyuan Guan, Shengfu Liu, Liying Luo, Zhong Wu, Shan Lu, Zhiqiang Guan, Kun Tao
Summary: This study investigates the prognosis of sarcoma patients and the genetic marker associated with iron residues. By analyzing gene expression and risk assessment models, the overall survival of patients is predicted. The study also explores the characteristics of the tumor microenvironment related to risk assessment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Orthopedics
Mingyi Yang, Yani Su, Ke Xu, Haishi Zheng, Qiling Yuan, Yongsong Cai, Yirixiati Aihaiti, Peng Xu
Summary: This study identified FRLncs that have the potential to influence OS prognosis and immune microenvironment, as well as immune checkpoint-related genes linked to OS prognosis. These findings establish a foundation for further investigations into OS survival and offer valuable insights for clinical decision making in the management of OS.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Immunology
Desheng Qi, Milin Peng
Summary: Cell death is a common biological process in various physiological and pathological conditions. There are multiple types of cell death, including apoptosis and the newly discovered ferroptosis. Ferroptosis has been found to have potential antitumor effects and may also impact immune cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yiming Zhang, Rong He, Xuan Lei, Lianghao Mao, Zhengyu Yin, Xinyu Zhong, Wenbing Cao, Qiping Zheng, Dapeng Li
Summary: Research on the implications of ferroptosis in tumors has rapidly increased in recent decades. This study found that the FRL model can predict the prognosis and immune characteristics of osteosarcoma patients, and is associated with key indicators in the immune tumor microenvironment. Additionally, knockdown of RPARP-AS1 suppressed the malignant activity of osteosarcoma cells, providing insight into more effective treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Lijie Chen, Xing Niu, Xue Qiao, Sai Liu, Hongmei Ma, Xueqing Shi, Xuemei He, Ming Zhong
Summary: This study provides a comprehensive analysis of the interplay between autophagy and ferroptosis in SCCs, and their synergistic roles in manipulating the immunological TME.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Yini Liu, Chunyan Duan, Rongyang Dai, Yi Zeng
Summary: Ferroptosis, a form of non-apoptotic regulated cell death primarily driven by iron-dependent lipid peroxidation, plays a significant role in cancer biology. Characterized by the accumulation of lipid peroxides and lethal reactive oxygen species, it differs from other types of cell death and can modulate cancer progression by reprogramming the tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Guanghao Li, Yongheng Liu, Yanting Zhang, Yao Xu, Jin Zhang, Xianfu Wei, Zhongmin Zhang, Chao Zhang, Jinyan Feng, Qiang Li, Guowen Wang
Summary: This study explores the prognostic value of ferroptosis-related lncRNAs in HCC patients. A novel signature consisting of five ferroptosis-related lncRNAs is established and shown to have a high clinical application value in predicting overall survival. The findings suggest that this signature could serve as an efficient indicator for predicting prognosis and guiding treatment in HCC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Di Zheng, Kezhou Xia, Zhun Wei, Zicheng Wei, Weichun Guo
Summary: This study systematically analyzed the transcriptional changes in osteosarcoma cells induced by RSL3 and constructed a novel three-gene signature related to ferroptosis, prognosis prediction, and immune microenvironment. The signature showed predictive value for prognosis in osteosarcoma patients and was closely associated with immune cell infiltration and immune-related activities.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Claudia Maria Hattinger, Iris Chiara Salaroglio, Leonardo Fantoni, Martina Godel, Chiara Casotti, Joanna Kopecka, Katia Scotlandi, Toni Ibrahim, Chiara Riganti, Massimo Serra
Summary: In order to improve the prognosis and cure rate of high-grade osteosarcomas (HGOSs), immune-based treatment approaches, especially for metastatic, relapsed and refractory HGOS patients, have been considered. This review provides an overview of immunotherapeutic treatments targeting, counteracting or exploiting the different immune cell compartments present in the HGOS tumor microenvironment. The strategies and possible mechanisms of HGOS cells to escape these treatments are discussed, as well as ongoing immune-based trials and recent clinical study results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Multidisciplinary Sciences
Yuyan Xie, Yang Zhou, Jiale Wang, Lijuan Du, Yuanyuan Ren, Fang Liu
Summary: Ferroptosis, a new form of cell death, is closely related to autophagy, and both play important roles in tumor progression, treatment, and drug resistance.
Review
Oncology
Tian Yun, Zhenzhu Liu, Jianbo Wang, Rui Wang, Liang Zhu, Zheng Zhu, Xuejian Wang
Summary: This paper describes the mechanism of ferroptosis in tumor therapy and immunotherapy, as well as the application and benefits of nanotechnology in the combination of tumor immunotherapy and ferroptosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Yuanyong Wang, Guofang Lu, Xinying Xue, Mei Xie, Zhaoyang Wang, Zhiqiang Ma, Yingtong Feng, Changjian Shao, Hongtao Duan, Minghong Pan, Peng Ding, Xiaofei Li, Jing Han, Xiaolong Yan
Summary: This study investigates the role of ferroptosis-related lncRNAs in lung adenocarcinoma (LUAD) and develops a prognostic model. The results show that 10 ferroptosis-related lncRNAs are independent predictors of LUAD outcome and may be involved in immune responses in LUAD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Qin Wang, Chunyan Zhu, Chao Fang, Junjie Liu, Kun Zhang, Yan Liu
Summary: In this study, exosomes derived from M1 macrophages were engineered to deliver RSL3 and induce ferroptosis in tumor cells, activating immune responses and mitigating the immunosuppressive tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Lijun Yu, Zhenwei Gao, Zeyu Li, Ping Liu, Ya Gao, Gang Liang
Summary: This study investigates the molecular characteristics of cervical squamous cell carcinoma (CESC) and predicts prognosis by analyzing ferroptosis-related gene (FRG) expression data. It identifies 21 FRGs associated with CESC prognosis and stratifies patients into different subtypes based on these genes, showing differences in prognosis, immune cell types, and immune checkpoint expression. A risk model based on FRG methylation levels is constructed and validated, highlighting its potential role in predicting CESC prognosis and assessing immune responses in patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)