Article
Immunology
Yuhao Xu, Yaoqiang Du, Qinghui Zheng, Tao Zhou, Buyun Ye, Yihao Wu, Qiuran Xu, Xuli Meng
Summary: A ferroptosis-related gene signature was developed to predict the recurrence-free survival and guide personalized treatment strategies for breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yilin Yan, Jinming Cai, Zhengnan Huang, Xiangqian Cao, Pengfei Tang, Zeyi Wang, Fang Zhang, Shujie Xia, Bing Shen
Summary: Our study identified a 6-gene signature based on ferroptosis-related genes in bladder cancer, which showed good prognostic ability and correlation with cancer characteristics, progression, and immune cell proportions. Targeting ferroptosis may be a therapeutic strategy for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Peicheng Jiang, Feng Yang, Caifeng Zou, Tianyuan Bao, Mengmeng Wu, Dongqin Yang, Shurui Bu
Summary: A prognostic signature of ferroptosis-related genes was identified for pancreatic cancer patients, showing that lower risk scores were associated with better overall survival. The signature also exhibited relevance with immune characteristics, suggesting potential for enhancing personalized immunotherapy efficacy.
Article
Multidisciplinary Sciences
Nan Wang, Yuanting Gu, Lin Li, Jiangrui Chi, Xinwei Liu, Youyi Xiong, Shan Jiang, Wudi Zhang, Chaochao Zhong
Summary: This study investigates the function of genes associated with ferroptosis in breast cancer and evaluates the relationship between gene expression and prognosis. A genetic risk signature is constructed based on ferroptosis-related genes, which can identify patient subgroups with distinct prognosis and is associated with the tumor immune microenvironment.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jianxin Zhong, Xi Shen, Junjie Zhou, Heping Yu, Birong Wang, Jianbin Sun, Jing Wang, Feng Liu
Summary: In this study, we developed a prognostic model using hypoxia and ferroptosis-related genes to predict the overall survival of breast cancer patients and characterize the tumor immune microenvironment. This research may provide new possibilities for clinical decision-making and individual treatment of breast cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kaiming Zhang, Liqin Ping, Tian Du, Gehao Liang, Yun Huang, Zhiling Li, Rong Deng, Jun Tang
Summary: This study identified a novel ferroptosis-related lncRNA signature that can accurately predict the prognosis of breast cancer patients. Patients in the high-risk group had worse prognosis, and immune-related pathways were significantly enriched in this group.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Zhou Fang, Zhi-Jie Gao, Xin Yu, Sheng-Rong Sun, Feng Yao
Summary: This study aimed to detect the expression of centrosome-related genes (CRGs) in normal and malignant breast tissues and construct a centrosome-related prognostic model for breast cancer. The differentially expressed CRGs were identified, and a centrosome-related signature (CRS) was developed to score breast cancer patients. The correlation between CRS and patient outcomes, clinical manifestations, mutational landscapes, tumor immune microenvironments, and responses to therapies were explored using various datasets. A nomogram was constructed for precise treatment guidance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Qin Liu, Jian-Ying Ma, Gaosong Wu
Summary: Utilizing a bioinformatics approach, a prognostic signature based on ferroptosis-related genes was established for predicting survival outcomes in breast cancer patients, showing significant differences in clinical features and treatment responses.
Article
Mathematical & Computational Biology
Yun-xiang Li, Shi-ming Wang, Chen-quan Li
Summary: The study identified four immune-related lncRNAs (RP11-890B15.3, RP11-1024P17.1, MFI2-AS1, and RP11-180N14.1) with independent prognostic value in TNBC patients. A prognostic risk model based on these lncRNAs effectively predicted patient survival outcomes. High-risk patients demonstrated enriched immune response and infiltrating immune cells, while specific lncRNAs regulated mRNA by targeting various miRNAs. These findings suggest that the identified lncRNAs could serve as prognostic biomarkers and potential therapeutic targets in TNBC.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Genetics & Heredity
Zhenlan Xie, Jialin Li, Chen Liu, Tie Zhao, Yixiang Xing
Summary: A 5-mRNA immune ferroptosis signature (IFRSig) was constructed and demonstrated good predictive ability in both training and validation cohorts. A correlation analysis revealed that clinical characteristics were closely related to risk characteristics. Our diagnostic model, combining risk characteristics and clinical parameters, was proven to accurately predict prognosis in BRCA. Additionally, patients were divided into low-risk and high-risk groups based on the expression of model-related genes, with the high-risk group showing lower levels of immune cell infiltration, immune-related functions, and immune checkpoint molecules, which may be associated with poor prognosis.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Lei Wang, Zixuan Wu, Chen Xu, Hang Ye
Summary: This study highlights the important role of ferroptosis-related genes (FRGs) in the pathogenesis and progression of pancreatic adenocarcinoma (PAAD). FRGs are upregulated in high-risk patients and are associated with immune and tumor-related pathways. Differences in immune function and RNA modification are observed between low-risk and high-risk groups. Additionally, several genes are identified as crucial mediators in PAAD pathogenesis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yutong Chen, Siqiao Zhao, Yihan Kang, Yuelin Zhang, Xu Chang
Summary: The study investigates the functional and immune patterns of ferroptosis-related genes (FRGs) in breast cancer and identifies prognostic FRGs and independent biomarkers for immunotherapies. The findings reveal the metabolic and immune characteristics of FRGs and their response to immunotherapies, providing insights into the interaction between ferroptosis and the tumor immune microenvironment (TIME).
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Immunology
Shuning Ding, Xi Sun, Li Zhu, Yafen Li, Weiguo Chen, Kunwei Shen
Summary: In this study, a four-gene signature based on immune-related genes was developed for prognostic prediction in breast cancer. The results showed that patients in the low-risk group had significantly better overall survival compared to those in the high-risk group. The immune-related prognostic signature (IRPS) was found to be an independent predictor of patient survival and when combined with clinical factors, showed good predictive performance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Jianglin Zheng, Zijie Zhou, Yue Qiu, Minjie Wang, Hao Yu, Zhipeng Wu, Xuan Wang, Xiaobing Jiang
Summary: This study identified prognostic ferroptosis-related lncRNAs in glioma and constructed a prognostic signature associated with the immune landscape of the glioma microenvironment and radiotherapy response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yajing Liu, Wenhao Ouyang, Hong Huang, Yujie Tan, Zebang Zhang, Yunfang Yu, Herui Yao
Summary: In this study, a tumor immune-inflammation signature consisting of 18 genes was identified and found to be a promising prognostic tool for estimating overall survival in breast cancer patients. It was also found to be correlated with immune status.
FRONTIERS IN ONCOLOGY
(2023)