Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

Glutathionylation: a regulatory role of glutathione in physiological processes

(2018) Kristina Dominko et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Glutathionylation Inhibits the Catalytic Activity of Arabidopsis β-Amylase3 but Not That of Paralog β-Amylase1

(2018) Amanda R. Storm et al.   BIOCHEMISTRY

S-Glutathionylation of estrogen receptor α affects dendritic cell function

(2018) Jie Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron–sulfur cluster biosynthesis and trafficking – impact on human disease conditions

(2018) C. Wachnowsky et al.   Metallomics

Hemodynamic Effects of Glutathione-Liganded Binuclear Dinitrosyl Iron Complex: Evidence for Nitroxyl Generation and Modulation by Plasma Albumin

(2018) Taiming Liu et al.   MOLECULAR PHARMACOLOGY

Protein–protein interactions of human glyoxalase II: findings of a reliable docking protocol

(2018) Roberta Galeazzi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy

(2018) D. Bartolini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Poloxamer-407 modified liposome encapsulating epigallocatechin-3-gallate in the presence of magnesium: Characterization and protective effect against oxidative damage

(2018) Cristina Minnelli et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Vitamin E: Emerging aspects and new directions

(2017) Francesco Galli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip

(2017) Alise J. Ponsero et al.   MOLECULAR CELL

Oxidative stress enhances and modulates protein S -nitrosation in smooth muscle cells exposed to S -nitrosoglutathione

(2017) E. Belcastro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma

(2017) Tatjana Djukic et al.   REDOX REPORT

The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo

(2017) Karilyn E. Sant et al.   Redox Biology

Glutathione Is the Resolving Thiol for Thioredoxin Peroxidase Activity of 1-Cys Peroxiredoxin Without Being Consumed During the Catalytic Cycle

(2016) José Rafael Pedrajas et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathionists in the battlefield of gamma-glutamyl cycle

(2016) Masayasu Inoue   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A possible S-glutathionylation of specific proteins by glyoxalase II: An in vitro and in silico study

(2016) Luisa Ercolani et al.   CELL BIOCHEMISTRY AND FUNCTION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

S-Glutathionylation of Keap1: a new role for glutathioneS-transferase pi in neuronal protection

(2016) Andreia Neves Carvalho et al.   FEBS LETTERS

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

(2016) Narciso Couto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The functional interactome of GSTP: A regulatory biomolecular network at the interface with the Nrf2 adaption response to oxidative stress

(2016) Desirée Bartolini et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria

(2016) Ryan J. Mailloux et al.   Redox Biology

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

(2016) Bradley A. Carlson et al.   Redox Biology

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

(2016) Tanja Krainz et al.   ACS Central Science

The Redox Code

(2015) Dean P. Jones et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress, redox regulation and diseases of cellular differentiation

(2015) Zhi-Wei Ye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

LINE-1 hypomethylation induced by reactive oxygen species is mediated via depletion of S-adenosylmethionine

(2015) Chiraphat Kloypan et al.   CELL BIOCHEMISTRY AND FUNCTION

The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins

(2015) Roland Lill et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its d,l-polylactide microparticle formulation

(2015) D. Bartolini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides

(2015) D. Bartolini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative protein folding: From thiol–disulfide exchange reactions to the redox poise of the endoplasmic reticulum

(2015) Devin A. Hudson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

Activity, regulation, copy number and function in the glyoxalase system

(2014) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Balancing oxidative protein folding: The influences of reducing pathways on disulfide bond formation

(2014) Kerstin Kojer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB

(2014) C Antognelli et al.   BRITISH JOURNAL OF CANCER

In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents

(2014) C. J. Henderson et al.   CANCER RESEARCH

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

(2014) Satoshi Tsunoda et al.   eLife

ProteinS-glutathionylation: from current basics to targeted modifications

(2014) Doina Popov   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Glutathione depletion in survival and apoptotic pathways

(2014) Milena De Nicola et al.   Frontiers in Pharmacology

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Roles of Reactive Oxygen Species in the Spermatogenesis Regulation

(2014) Giulia Guerriero et al.   Frontiers in Endocrinology

Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure

(2013) José Luis García-Giménez et al.   ANTIOXIDANTS & REDOX SIGNALING

STAT3 Regulation by S-Nitrosylation: Implication for Inflammatory Disease

(2013) Jinsu Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

The metabolic function of hepatocytes differentiated from human mesenchymal stem cells is inversely related to cellular glutathione levels

(2013) Abdolamir Allameh et al.   CELL BIOCHEMISTRY AND FUNCTION

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

S-D-Lactoylglutathione can be an alternative supply of mitochondrial glutathione

(2013) Tatiana Armeni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Blood thiol status and erythrocyte glutathione-S-transferase in chronic kidney disease patients on treatment with frequent (daily) hemodialysis

(2013) F. Galli et al.   FREE RADICAL RESEARCH

Causes and Consequences of CysteineS-Glutathionylation

(2013) Christina L. Grek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

(2013) Edward Avezov et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic reticulum: reduced and oxidized glutathione revisited

(2013) J. Birk et al.   JOURNAL OF CELL SCIENCE

Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms

(2013) Francesco Regoli et al.   MARINE ENVIRONMENTAL RESEARCH

Glycation of human high density lipoprotein by methylglyoxal: Effect on HDL-paraoxonase activity

(2013) Tiziana Bacchetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Glutathione redox potential is low and glutathionylated and cysteinylated hemoglobin levels are elevated in maintenance hemodialysis patients

(2013) Khaled Khazim et al.   Translational Research

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Folding in the Endoplasmic Reticulum

(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

Intracellular glutathione pools are heterogeneously concentrated

(2013) Davide Montero et al.   Redox Biology

Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

(2013) Ryan J. Mailloux et al.   Redox Biology

Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury

(2012) Morgan L. Locy et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione-S-Transferases As Determinants of Cell Survival and Death

(2012) Kenneth D. Tew et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidation of the Yeast Mitochondrial Thioredoxin Promotes Cell Death

(2012) Darren Greetham et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutaredoxins in Thiol/Disulfide Exchange

(2012) Christopher Horst Lillig et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase

(2012) Chao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

The biological roles of glutaredoxins

(2012) Elke Ströher et al.   BIOCHEMICAL JOURNAL

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state

(2012) Kerstin Kojer et al.   EMBO JOURNAL

Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation

(2012) Y. Manevich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis

(2012) Bruce Morgan et al.   Nature Chemical Biology

Cellular Redox Imbalance and Changes of Protein S-glutathionylation Patterns Are Associated with Senescence Induced by Oncogenic H-Ras

(2012) Tatiana Armeni et al.   PLoS One

Glutathione synthesis and its role in redox signaling

(2012) Hongqiao Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Low-Molecular-Weight Oxidants Involved in Disulfide Bond Formation

(2011) Lloyd W. Ruddock   ANTIOXIDANTS & REDOX SIGNALING

Treatment of doxorubicin-resistant MCF7/Dx cells with nitric oxide causes histone glutathionylation and reversal of drug resistance

(2011) Anastasia de Luca et al.   BIOCHEMICAL JOURNAL

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

(2011) Larry G. Higgins et al.   DRUG METABOLISM REVIEWS

Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control

(2011) Chitranshu Kumar et al.   EMBO JOURNAL

Reversible and irreversible protein glutathionylation: biological and clinical aspects

(2011) Arthur JL Cooper et al.   Expert Opinion on Drug Metabolism & Toxicology

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

(2011) Ryan J. Mailloux et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

(2011) Justin R. Prigge et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functionalin VitroAnalysis of the ERO1 Protein and Protein-disulfide Isomerase Pathway

(2011) Kazutaka Araki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a′

(2011) Chao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum

(2011) C. Appenzeller-Herzog   JOURNAL OF CELL SCIENCE

Real-time monitoring of redox changes in the mammalian endoplasmic reticulum

(2011) M. van Lith et al.   JOURNAL OF CELL SCIENCE

Glutathione: mechanism and kinetics of its non-enzymatic defense action against free radicals

(2011) Annia Galano et al.   RSC Advances

Nitric Oxide Signaling and Nitrosative Stress in Neurons: Role for S-Nitrosylation

(2010) Neelam Shahani et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 6: A Bifunctional Enzyme with Glutathione Peroxidase and Phospholipase A2 Activities

(2010) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

A nuclear glutathione cycle within the cell cycle

(2010) Pedro Diaz Vivancos et al.   BIOCHEMICAL JOURNAL

Cardiac electrophysiological effects of nitric oxide

(2010) Juan Tamargo et al.   CARDIOVASCULAR RESEARCH

Glutathione cycle in stable chronic obstructive pulmonary disease

(2010) Vanja Radišić Biljak et al.   CELL BIOCHEMISTRY AND FUNCTION

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum

(2010) Timothy J Tavender et al.   EMBO JOURNAL

Pathological implications of cell cycle re-entry in Alzheimer disease

(2010) David J. Bonda et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Oxidative folding in the endoplasmic reticulum: Towards a multiple oxidant hypothesis?

(2010) Éva Margittai et al.   FEBS LETTERS

Modulation of cardiac ryanodine receptor activity by ROS and RNS

(2010) Paulina Donoso   Frontiers in Bioscience-Landmark

The Reduction Potential of the Active Site Disulfides of Human Protein Disulfide Isomerase Limits Oxidation of the Enzyme by Ero1α

(2010) Joseph E. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Mitochondrial Glutathione Redox Status and Protein Glutathionylation by Respiratory Substrates

(2010) Jerome Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Synthesis and Turnover in the Human Erythrocyte

(2010) Julia E. Raftos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Recruitment of glutathione into the nucleus during cell proliferation adjusts whole-cell redox homeostasis in Arabidopsis thaliana and lowers the oxidative defence shield

(2010) Pedro Diaz Vivancos et al.   PLANT JOURNAL

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Physiological levels of glutathione enhance Zn(II) binding by a Cys4 zinc finger

(2009) Katarzyna Piątek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thiol−Disulfide Exchange between Glutaredoxin and Glutathione

(2009) Rasmus Iversen et al.   BIOCHEMISTRY

Catalytic mechanisms and specificities of glutathione peroxidases: Variations of a basic scheme

(2009) Stefano Toppo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nitrosative Stress-Induced S-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response

(2009) D. M. Townsend et al.   CANCER RESEARCH

In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes

(2009) Luis Torres et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant Activity of the Yeast Mitochondrial One-Cys Peroxiredoxin Is Dependent on Thioredoxin Reductase and Glutathione In Vivo

(2009) D. Greetham et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of nuclear glutathione as a key regulator of cell proliferation

(2009) Federico V. Pallardó et al.   MOLECULAR ASPECTS OF MEDICINE

Pyridine Nucleotide Cycling and Control of Intracellular Redox State in Relation to Poly (ADP-Ribose) Polymerase Activity and Nuclear Localization of Glutathione during Exponential Growth of Arabidopsis Cells in Culture

(2009) Till K. Pellny et al.   Molecular Plant

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular thiol-assisted selenium uptake dependent on the xc- cystine transporter explains the cancer-specific cytotoxicity of selenite

(2009) E. Olm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein S-glutathionylation: a regulatory device from bacteria to humans

(2009) Isabella Dalle-Donne et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein S-nitrosylation in health and disease: a current perspective

(2009) Matthew W. Foster et al.   TRENDS IN MOLECULAR MEDICINE

Assessment of Endoplasmic Reticulum Glutathione Redox Status Is Confounded by Extensive Ex Vivo Oxidation

(2008) Brian M. Dixon et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Efficient Peroxide-Mediated Oxidative Refolding of a Protein at Physiological pH and Implications for Oxidative Folding in the Endoplasmic Reticulum

(2008) Anna–Riikka Karala et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatic mitochondrial transport of glutathione: Studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells

(2008) Qing Zhong et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Kinetic and Mechanistic Characterization and Versatile Catalytic Properties of Mammalian Glutaredoxin 2: Implications for Intracellular Roles†

(2008) Molly M. Gallogly et al.   BIOCHEMISTRY

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation

(2008) Montserrat Marí et al.   GASTROENTEROLOGY

Reconstitution of Human Ero1-Lα/Protein-Disulfide Isomerase Oxidative Folding Pathwayin Vitro

(2008) Lei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role for GlutathioneS-Transferase π

(2008) Danyelle M. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition

(2008) Anna W. C. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphate Is Essential for Inhibition of the Mitochondrial Permeability Transition Pore by Cyclosporin A and by Cyclophilin D Ablation

(2008) Emy Basso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Novel function of glutathione transferase in rat liver mitochondrial membrane: Role for cytochrome c release from mitochondria☆⁎Some of the data were presented at the ISSX (International Society for Study of Xenobiotics) Meeting, Oct.12, 2007, in Sendai, Japan.

(2008) Kang Kwang Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular Mechanisms and Potential Clinical Significance of S-Glutathionylation

(2007) Isabella Dalle–Donne et al.   ANTIOXIDANTS & REDOX SIGNALING