Article
Multidisciplinary Sciences
Peipei Cui, Mingjiang Cai, Yanan Meng, Yan Yang, Hongjian Song, Yuxiu Liu, Qingmin Wang
Summary: In this study, a series of echinopsine derivatives containing acylhydrazone moieties were designed, synthesized, and evaluated for their biological activities. The compounds showed good antiviral activity against tobacco mosaic virus, as well as insecticidal and fungicidal activities.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Hosam M. Habib, Hamada El-Gendi, Esmail M. El-Fakharany, Mohamed G. El-Ziney, Ahmed F. El-Yazbi, Fatima T. Al Meqbaali, Wissam H. Ibrahim
Summary: The polyphenolic profile of pomegranate juice concentrate was investigated for the first time, revealing its potential health benefits and antioxidant activity. The concentrate exhibited inhibitory effects on oxidative damage and enzyme activities. It also demonstrated antibacterial effects and dose-dependent apoptosis on cancer cells.
Article
Chemistry, Multidisciplinary
Malik Suliman Mohamed, Khaled M. Elamin, Rawaf Alenazy, Eyman Mohamed Eltayib, Mona Timan Idriss, Noura A. A. Alhudaib, Tilal Elsaman, Magdi Awadalla Mohamed
Summary: Novel 5-nitrofuran-isatin molecular hybrids were synthesized and evaluated for their antimicrobial activity. Hybrids 5 and 6 exhibited higher potency against Methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration values of 8 and 1 μg/mL, respectively. Furthermore, these hybrids showed good safety and demonstrated potent inhibitory activity against the human colon cancer cell line HCT 116, with isatin hybrid 3 being the most effective.
JOURNAL OF CHEMISTRY
(2023)
Review
Agriculture, Multidisciplinary
Fazlurrahman Khan, Nazia Tabassum, Nilushi Indika Bamunuarachchi, Young-Mog Kim
Summary: Phloroglucinol and its derivatives have been widely used to treat microbial infections and exhibit diverse biological activities. With the increasing resistance of microorganisms to antimicrobial drugs, the synthesis of more phloroglucinol derivatives is crucial to meet the growing demand. This review provides an overview of the application of phloroglucinol and its derivatives in antibacterial action and explores their potential future perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Yuewen Liu, Jixiang Chen, Dandan Xie, Baoan Song, Deyu Hu
Summary: Tomato spotted wilt virus (TSWV) is a plant virus causing significant economic damage worldwide. Compound 6n, a novel quinazolinone derivative, showed excellent anti-TSWV activity in vitro and in vivo, with better binding affinity to TSWV coat protein compared to ribavirin, xiangcaoliusuobingmi, and ningnanmycin. Compound 6n has the potential to serve as a lead compound for the discovery of new antiviral agents for TSWV management.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Yasser M. Okasha, Fify I. Fathy, Fathy M. Soliman, Nesrin M. Fayek
Summary: The methanol extract from the leaves and flowers of Verbascum thapsus L. has been found to possess antiviral and antibacterial activities, particularly against coronaviruses, hepatitis B virus, and herpes simplex virus.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Materials Science, Multidisciplinary
N. Jayarambabu, T. Venkatappa Rao, R. Rakesh Kumar, A. Akshaykranth, Kalakotla Shanker, Velpula Suresh
Summary: Nanoparticles, specifically Zinc oxide nanoparticles (ZnO NPs), have shown potential in effectively treating diabetes, as well as exhibiting antibacterial and anticancer properties. Further experiments are required to determine the specific mechanism of ZnO NPs for their anti-hyperglycemic activity, highlighting their prospective pharmaceutical applications.
MATERIALS TODAY COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Hesham R. El-Seedi, Nermeen Yosri, Bishoy El-Aarag, Shaymaa H. Mahmoud, Ahmed Zayed, Ming Du, Aamer Saeed, Syed G. Musharraf, Islam M. El-Garawani, Mohamed R. Habib, Haroon Elrasheid Tahir, Momtaz M. Hegab, Xiaobo Zou, Zhiming Guo, Thomas Efferth, Shaden A. M. Khalifa
Summary: Cardiotonic steroids are hormones found in the blood of amphibians and toads, as well as in natural products like plants, herbs, and marines. They have effects against congestive heart failure and atrial fibrillation, and are divided into two groups: cardenolides and bufadienolides. This review focuses on their chemistry, antiviral, and anticancer activities, particularly in combating chronic health problems caused by cancer, viruses, and inflammations. Various cardiotonic steroids from toad venom have been isolated and shown to exhibit superior activities. Identification of these compounds and their bioactivities has been achieved using molecular and biotechnological techniques.
Article
Pharmacology & Pharmacy
Cristina Ardean, Corneliu Mircea Davidescu, Nicoleta Sorina Nemes, Adina Negrea, Mihaela Ciopec, Narcis Duteanu, Petru Negrea, Daniel Duda-Seiman, Delia Muntean
Summary: Research shows that new molecules and materials with specific properties against drug-resistant microorganisms, such as chitosan, can be synthesized to enhance antimicrobial activities. Testing revealed that materials functionalized with chitosan and quaternary ammonium salts exhibited the best antimicrobial activity.
Article
Polymer Science
Naushad Ahmad, Mohammad Rizwan Khan, Subramanian Palanisamy, Sonaimuthu Mohandoss
Summary: This study successfully developed chitosan nanoparticles encapsulated with cisplatin and 5-fluorouracil, which demonstrated antibacterial and anticancer activities. The nanoparticles were able to control and sustain the release of the drugs, and showed significant inhibitory effects on the growth of cancer cells.
Article
Polymer Science
Alba Cano-Vicent, Andrea Martinez-Agut, Alberto Tunon-Molina, Hamid Bakshi, Roser Sabater i Serra, Iman M. Alfagih, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: Alginate crosslinked with calcium cations is a promising hydrogel for biomedical applications due to its non-toxicity, suitable mechanical properties, and insolubility in water. This study explored the biological properties of alginate films crosslinked with Ca2+ and Co2+ ions, including antiviral capacity, antibacterial properties, and anticancer activity. The results showed that the hydrogel exhibited biocompatibility in vivo and in vitro, as well as antibacterial and antiviral activity against methicillin-resistant Staphylococcus aureus and a surrogate of SARSCoV-2. Additionally, the hydrogel showed anticancer properties against melanoma and colon cancer cells.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Infectious Diseases
Firzan Nainu, Ayu Masyita, Muh. Akbar Bahar, Muhammad Raihan, Shajuthi Rahman Prova, Saikat Mitra, Talha Bin Emran, Jesus Simal-Gandara
Summary: Bee products have been traditionally used for treating various disorders, including cancer and microbial-related diseases. Compounds found in bee products show potential in anticancer, antibacterial, antiviral, and antiparasitic activity, making them promising for cancer and infectious disease management.
Article
Chemistry, Multidisciplinary
Satoshi Seino, Yuji Ohkubo, Tomonari Magara, Hiroki Enomoto, Eri Nakajima, Tomoki Nishida, Yasuo Imoto, Takashi Nakagawa
Summary: A new method has been developed to introduce the antimicrobial activity of silver nanoparticles into resin substrates. By irradiating the resin substrate with gamma ray or high energy electron beams, silver nanoparticles were immobilized on the resin surface through chemical reactions induced by ionizing radiation. Various resin materials were found to be applicable for this process, and despite the low amount of silver loading, the obtained samples exhibited high antibacterial and antiviral activities.
Article
Chemistry, Medicinal
Juan Wang, Boqiang Liang, Yiling Chen, Jasper Fuk-Woo Chan, Shuofeng Yuan, Hui Ye, Linlin Nie, Jiao Zhou, Yi Wu, Meixian Wu, Lina S. Huang, Jing An, Arieh Warshel, Kwok-Yung Yuen, Aaron Ciechanover, Ziwei Huang, Yan Xu
Summary: Novel alpha-keto phenylamide derivatives were designed, synthesized and characterized in this study to target both the primed and non-primed sites of the proteasome, showing potent anticancer and antiviral activities. Experimental evidence suggests that these derivatives can be potential candidates for developing antiviral therapeutics for COVID-19, as they effectively inhibit cellular infection of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Eda Becer, Ergul Mutlu Altundag, Mumtaz Guran, H. Seda Vatansever, Selma Usturk, Duygu Yigit Hanoglu, K. Husnu Can Baser
Summary: The composition, in vitro anticancer, antioxidant, and antibacterial activities of rosemary essential oil were investigated in this study. The major compounds of rosemary essential oil were identified as camphor(15.1%), verbenone(14.3%), α-pinene(13.6%), 1,8-cineole(11.8%), and borneol(7.9%). The essential oil exhibited significant inhibitory activity against HepG2 and ECV304 cells, as well as antioxidant and antibacterial activities against Escherichia coli and Klebsiella pneumoniae. These findings suggest that rosemary essential oil has the potential as a therapeutic agent in cancer treatment.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
