System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

Regulation of the System x−C cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures

(2011) Todd Michael Seib et al.   GLIA

Molecular Diffusion Model of Neurotransmitter Homeostasis Around Synapses Supporting Gradients

(2011) Ashwin Mohan et al.   NEURAL COMPUTATION

Overexpression of xCT induces up-regulation of 14-3-3β in Kaposi's sarcoma

(2010) Yan Zeng et al.   BIOSCIENCE REPORTS

Regulation of System xc−Activity and Expression in Astrocytes by Interleukin-1β

(2010) Nicole A. Jackman et al.   GLIA

Glutamate and the biology of gliomas

(2010) John de Groot et al.   GLIA

Hypoxia Increases the Dependence of Glioma Cells on Glutathione

(2010) Toyin Adeyemi Ogunrinu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats

(2010) A. Madayag et al.   JOURNAL OF NEUROSCIENCE

Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-γ-lyase and upregulation of the transsulfuration pathway in C6 glioma cells

(2010) Sarah Kandil et al.   NEUROCHEMISTRY INTERNATIONAL

Repeated N-Acetyl Cysteine Reduces Cocaine Seeking in Rodents and Craving in Cocaine-Dependent Humans

(2010) Shelley L Amen et al.   NEUROPSYCHOPHARMACOLOGY

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Isoxazole analogues bind the System xc- transporter: Structure–activity relationship and pharmacophore model

(2009) Sarjubhai A. Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system over the vesicular glutamate transporter

(2009) Jean-Louis G. Etoga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glutamate and reinstatement

(2009) Lori A Knackstedt et al.   CURRENT OPINION IN PHARMACOLOGY

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB

(2009) W. Joon Chung et al.   JOURNAL OF NEUROCHEMISTRY

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE

The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans

(2008) Lori A. Knackstedt et al.   BIOLOGICAL PSYCHIATRY

Synthesis and preliminary pharmacological evaluation of novel derivatives of l-β-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3

(2008) Terri L. Mavencamp et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine

(2008) Jun Guan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Characterization of the cystine/glutamate transporter in the outer plexiform layer of the vertebrate retina

(2008) Rebecca G. Hu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A role for glutamate in growth and invasion of primary brain tumors

(2008) Harald Sontheimer   JOURNAL OF NEUROCHEMISTRY

Glutamate transmission in addiction

(2008) Peter W. Kalivas et al.   NEUROPHARMACOLOGY

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE

xCT expression reduces the early cell cycle requirement for calcium signaling

(2007) Michele Lastro et al.   CELLULAR SIGNALLING

Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines

(2007) Girish C. Daginakatte et al.   EXPERIMENTAL NEUROLOGY

Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement

(2006) P M Beart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

(2003) Steven W. Barger et al.   JOURNAL OF NEUROCHEMISTRY