Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment

(2020) Yanyu Jiang et al.   CELL BIOLOGY AND TOXICOLOGY

Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

(2020) Yongfei Yang et al.   Nature Communications

Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer

(2020) Kudelaidi Kuerban et al.   Acta Pharmaceutica Sinica B

Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway

(2020) Yunjiang Zhou et al.   CANCER LETTERS

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

(2020) Yingchuan Li et al.   CELL DEATH AND DIFFERENTIATION

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice

(2020) Xin Zhang et al.   ACTA PHARMACOLOGICA SINICA

Acetyl-11-keto-β-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway

(2020) Minghe Lv et al.   CELL BIOLOGY AND TOXICOLOGY

Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer

(2020) Jiawen Zhang et al.   CELL DEATH AND DIFFERENTIATION

FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1

(2020) Guo-Hua Fan et al.   CELLULAR SIGNALLING

Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity

(2020) Can Hu et al.   Clinical and Translational Medicine

Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways

(2020) Yangyang Guo et al.   CELL BIOLOGY AND TOXICOLOGY

Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species

(2020) Natividad Blasco et al.   Redox Biology

Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway

(2020) Can Hu et al.   Redox Biology

Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway

(2019) Can Hu et al.   Acta Pharmaceutica Sinica B

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer

(2019) Qi Zhang et al.   CELL DEATH AND DIFFERENTIATION

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Overcoming acquired resistance of gefitinib in lung cancer cells without T790M by AZD9291 or Twist1 knockdown in vitro and in vivo

(2019) Zhongwei Liu et al.   ARCHIVES OF TOXICOLOGY

Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis

(2019) Yanyu Jiang et al.   CELL BIOLOGY AND TOXICOLOGY

Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells

(2019) Zeng-li Zhang et al.   ACTA PHARMACOLOGICA SINICA

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

(2019) Xin Zhang et al.   CELL DEATH AND DIFFERENTIATION

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

Lipid metabolism offers anticancer treatment by regulating ferroptosis

(2019) Michele Carbone et al.   CELL DEATH AND DIFFERENTIATION

Iron and lung cancer

(2019) Yanbin Kuang et al.   CANCER LETTERS

The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis

(2019) Xingyun Wang et al.   CELL DEATH AND DIFFERENTIATION

PEP06 polypeptide 30 is a novel cluster-dissociating agent inhibiting v integrin/FAK/Src signaling in oral squamous cell carcinoma cells

(2019) Gulnara Tuguzbaeva et al.   Acta Pharmaceutica Sinica B

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14

(2018) Fei Yu et al.   CANCER LETTERS

USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma

(2018) Huijuan Zhang et al.   CANCER LETTERS

Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF

(2018) Aram Ko et al.   CELL DEATH AND DIFFERENTIATION

USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

(2018) Chenming Wu et al.   CELL DEATH AND DIFFERENTIATION

A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification

(2018) Sarah Nicklas et al.   CELL DEATH AND DIFFERENTIATION

Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling

(2018) Xin Zhang et al.   Cell Death & Disease

USP35 regulates mitotic progression by modulating the stability of Aurora B

(2018) Jinyoung Park et al.   Nature Communications

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer

(2018) Xiang-lin Hao et al.   CELL DEATH AND DIFFERENTIATION

C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice

(2018) Zhen-Guo Ma et al.   CARDIOVASCULAR RESEARCH

Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

(2018) Yuan Zhang et al.   Acta Pharmaceutica Sinica B

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

miR-20a regulates expression of the iron exporter ferroportin in lung cancer

(2015) Kamesh R. Babu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2

(2015) Chunyan Liu et al.   Oncotarget

MicroRNA-34a overcomes HGF-mediated gefitinib resistance in EGFR mutant lung cancer cells partly by targeting MET

(2014) Jian-Ya Zhou et al.   CANCER LETTERS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

(2012) Bo Qiao et al.   Cell Metabolism

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry