- Home
- Publications
- Publication Search
- Publication Details
Title
Tackling the cancer stem cells — what challenges do they pose?
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 13, Issue 7, Pages 497-512
Publisher
Springer Nature
Online
2014-07-01
DOI
10.1038/nrd4253
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Molecular identification and targeting of colorectal cancer stem cells
- (2015) Oncotarget
- Evolution of the Cancer Stem Cell Model
- (2014) Antonija Kreso et al. Cell Stem Cell
- Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate
- (2014) Yasuharu Nakashima et al. Modern Rheumatology
- Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
- (2013) Wai Leong Tam et al. CANCER CELL
- Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
- (2013) Chenfang Dong et al. CANCER CELL
- JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells
- (2013) P. Kroon et al. CANCER RESEARCH
- Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
- (2013) A. Jimeno et al. CLINICAL CANCER RESEARCH
- Targeting TGF-β signaling in cancer
- (2013) Lior H Katz et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
- (2013) Suzanne Richter et al. INVESTIGATIONAL NEW DRUGS
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer stem cells: The challenges ahead
- (2013) Jan Paul Medema NATURE CELL BIOLOGY
- The epigenetics of epithelial-mesenchymal plasticity in cancer
- (2013) Wai Leong Tam et al. NATURE MEDICINE
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
- (2013) M. Yu et al. SCIENCE
- A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis
- (2013) Xinrong Ma et al. OncoImmunology
- Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205
- (2012) Martin Puhr et al. AMERICAN JOURNAL OF PATHOLOGY
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
- (2012) Oscar H. Ocaña et al. CANCER CELL
- Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis
- (2012) Jeff H. Tsai et al. CANCER CELL
- Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
- (2012) Eleftherios Sachlos et al. CELL
- Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
- (2012) Wenjun Guo et al. CELL
- β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
- (2012) Joseph Rosenbluh et al. CELL
- EMT and Dissemination Precede Pancreatic Tumor Formation
- (2012) Andrew D. Rhim et al. CELL
- Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML
- (2012) Florian H. Heidel et al. Cell Stem Cell
- The extracellular matrix: A dynamic niche in cancer progression
- (2012) Pengfei Lu et al. JOURNAL OF CELL BIOLOGY
- Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
- (2012) Toni Celià-Terrassa et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein
- (2012) Bikash Debnath et al. JOURNAL OF MEDICINAL CHEMISTRY
- MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
- (2012) D. W. Jenkins et al. MOLECULAR CANCER THERAPEUTICS
- Defining the mode of tumour growth by clonal analysis
- (2012) Gregory Driessens et al. NATURE
- RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
- (2012) Min Yu et al. NATURE
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- A restricted cell population propagates glioblastoma growth after chemotherapy
- (2012) Jian Chen et al. NATURE
- Epithelial Mesenchymal Transition and Pancreatic Tumor Initiating CD44+/EpCAM+ Cells Are Inhibited by γ-Secretase Inhibitor IX
- (2012) Vindhya Palagani et al. PLoS One
- Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy
- (2012) S. M. McAuliffe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas
- (2012) A. G. Schepers et al. SCIENCE
- Phosphosulindac (OXT-328) Selectively Targets Breast Cancer Stem Cells In Vitro and in Human Breast Cancer Xenografts
- (2012) Caihua Zhu et al. STEM CELLS
- Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target
- (2012) Christophe Ginestier et al. STEM CELLS
- Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway
- (2012) Jian Yang et al. STEM CELLS
- Emodin As an Effective Agent in Targeting Cancer Stem-Like Side Population Cells of Gallbladder Carcinoma
- (2012) Xin-xing Li et al. STEM CELLS AND DEVELOPMENT
- Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E 2 Signaling
- (2012) Hua-Jung Li et al. Cancer Discovery
- Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
- (2012) Roman Mezencev et al. Journal of Ovarian Research
- The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease
- (2011) M. Angela Nieto Annual Review of Cell and Developmental Biology
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
- (2011) Kathrin M. Bernt et al. CANCER CELL
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
- (2011) Michael Quante et al. CANCER CELL
- Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells
- (2011) T. S. Zhu et al. CANCER RESEARCH
- Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks
- (2011) Suling Liu et al. CANCER RESEARCH
- STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells
- (2011) L. Lin et al. CANCER RESEARCH
- Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion
- (2011) B. Dirat et al. CANCER RESEARCH
- Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
- (2011) Piyush B. Gupta et al. CELL
- Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
- (2011) Christina Scheel et al. CELL
- Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding
- (2011) R. A. Graham et al. CLINICAL CANCER RESEARCH
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Identification of CD44+CD24+ gastric cancer stem cells
- (2011) Chaojun Zhang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
- (2011) Lauren L.C. Marotta et al. JOURNAL OF CLINICAL INVESTIGATION
- A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
- (2011) Howard Trachtman et al. KIDNEY INTERNATIONAL
- CD90 is Identified as a Candidate Marker for Cancer Stem Cells in Primary High-Grade Gliomas Using Tissue Microarrays
- (2011) Jintang He et al. MOLECULAR & CELLULAR PROTEOMICS
- A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells
- (2011) K. Visnyei et al. MOLECULAR CANCER THERAPEUTICS
- Tumour evolution inferred by single-cell sequencing
- (2011) Nicholas Navin et al. NATURE
- Interactions between cancer stem cells and their niche govern metastatic colonization
- (2011) Ilaria Malanchi et al. NATURE
- Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
- (2011) M. Jinushi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
- (2011) F. C. Gonsalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
- (2011) C. L. Chaffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
- (2011) David G. DeNardo et al. Cancer Discovery
- An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
- (2010) K. P. A. MacDonald et al. BLOOD
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells
- (2010) Jenny Yeung et al. CANCER CELL
- TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
- (2010) Judit Anido et al. CANCER CELL
- Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor
- (2010) H. Harrison et al. CANCER RESEARCH
- A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth
- (2010) Alexander Roesch et al. CELL
- Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content
- (2010) Salvatore Pece et al. CELL
- Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
- (2010) Stefan Gross et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Selection of Tumorigenic Melanoma Cells Using ALDH
- (2010) Jim B. Boonyaratanakornkit et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma
- (2010) Zeshaan A. Rasheed et al. JNCI-Journal of the National Cancer Institute
- Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
- (2010) Louis Vermeulen et al. NATURE CELL BIOLOGY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers
- (2010) Shan Deng et al. PLoS One
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells
- (2010) Venkata Lokesh Battula et al. STEM CELLS
- Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance
- (2010) Nathan Moore et al. Journal of Oncology
- Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer
- (2009) Yu-Chih Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- GDC-0449—A potent inhibitor of the hedgehog pathway
- (2009) Kirk D. Robarge et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Slow proliferation as a biological feature of colorectal cancer metastasis
- (2009) A Anjomshoaa et al. BRITISH JOURNAL OF CANCER
- The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
- (2009) Michael Hedvat et al. CANCER CELL
- CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages
- (2009) David G. DeNardo et al. CANCER CELL
- Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer
- (2009) J. E. Carpentino et al. CANCER RESEARCH
- Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis
- (2009) E. H. Huang et al. CANCER RESEARCH
- Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
- (2009) Piyush B. Gupta et al. CELL
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency
- (2009) Timothy Hoey et al. Cell Stem Cell
- PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells
- (2009) Anne-Marie Bleau et al. Cell Stem Cell
- Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors
- (2009) S. Rutella et al. CLINICAL CANCER RESEARCH
- Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion
- (2009) Ayano Kabashima et al. INTERNATIONAL JOURNAL OF CANCER
- Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
- (2009) Martin R. Tremblay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Drugging the Wnt Pathway: Problems And Progress
- (2009) K. Garber JNCI-Journal of the National Cancer Institute
- Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
- (2009) F. Jiang et al. MOLECULAR CANCER RESEARCH
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
- (2009) Baozhi Chen et al. Nature Chemical Biology
- A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
- (2009) Pierre Farmer et al. NATURE MEDICINE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
- (2009) L Lin et al. ONCOGENE
- Chemoattractant Signaling between Tumor Cells and Macrophages Regulates Cancer Cell Migration, Metastasis and Neovascularization
- (2009) Chad E. Green et al. PLoS One
- Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
- (2009) G. Bertolini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
- (2009) Nawneet K. Kurrey et al. STEM CELLS
- STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells
- (2009) Maureen M. Sherry et al. STEM CELLS
- Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44
- (2009) Shigeo Takaishi et al. STEM CELLS
- Transforming growth factor-β signaling: emerging stem cell target in metastatic breast cancer?
- (2008) Antoinette R. Tan et al. BREAST CANCER RESEARCH AND TREATMENT
- Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
- (2008) Christine Dierks et al. CANCER CELL
- Significance of CD90+ Cancer Stem Cells in Human Liver Cancer
- (2008) Zhen Fan Yang et al. CANCER CELL
- Cancer related inflammation: The macrophage connection
- (2008) Antonio Sica et al. CANCER LETTERS
- Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells
- (2008) Stefania Cannito et al. CARCINOGENESIS
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment
- (2008) Toula Bouras et al. Cell Stem Cell
- Recent Progress in the Medicinal Chemistry of γ-Secretase Inhibitors
- (2008) Richard Olson et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
- (2008) Satori A Marchitti et al. Expert Opinion on Drug Metabolism & Toxicology
- Identification of local and circulating cancer stem cells in human liver cancer
- (2008) Zhen Fan Yang et al. HEPATOLOGY
- Characterization of a side population of astrocytoma cells in response to temozolomide
- (2008) Constance Chua et al. JOURNAL OF NEUROSURGERY
- Aldehyde Dehydrogenase Discriminates the CD133 Liver Cancer Stem Cell Populations
- (2008) S. Ma et al. MOLECULAR CANCER RESEARCH
- Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
- (2008) Ilaria Malanchi et al. NATURE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Efficient tumour formation by single human melanoma cells
- (2008) Elsa Quintana et al. NATURE
- Repression of E-cadherin by the polycomb group protein EZH2 in cancer
- (2008) Q Cao et al. ONCOGENE
- Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
- (2008) Anne-Pierre Morel et al. PLoS One
- Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
- (2008) L. Vermeulen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
- Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice
- (2007) Lorea Bueno et al. EUROPEAN JOURNAL OF CANCER
- Expression of CD133-1 and CD133-2 in ovarian cancer
- (2007) G. FERRANDINA et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1Murine Breast Tumors
- (2007) Robert W. Cho et al. STEM CELLS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now