Deciphering clock genes as emerging targets against aging

Clock Gene Bmal1 Disruption in Vascular Smooth Muscle Cells Worsens Carotid Atherosclerotic Lesions

(2022) Changpo Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Day-night oscillations of cognitive functions, TNF alpha and clock -related factors expression are modified by an intracerebroventricular injection of amyloid beta peptide in rat

(2022) Carina Ledezma et al.   NEUROCHEMISTRY INTERNATIONAL

REV-ERB Agonist SR9009 Regulates the Proliferation and Neurite Outgrowth/Suppression of Cultured Rat Adult Hippocampal Neural Stem/Progenitor Cells in a Concentration-Dependent Manner

(2021) Koji Shimozaki   CELLULAR AND MOLECULAR NEUROBIOLOGY

Diagnosis and Treatment of Hip and Knee Osteoarthritis

(2021) Jeffrey N. Katz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Clock knockdown attenuated reactive oxygen species-mediated senescence of chondrocytes through restoring autophagic flux

(2021) Junlong Zhong et al.   LIFE SCIENCES

Neuronal Differentiation 1 gene Ala45Thr polymorphism and type 2 diabetes mellitus: a meta-analysis of 7,940 subjects

(2021) Yan-yan Li et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis

(2021) Lei Xu et al.   ACTA PHARMACOLOGICA SINICA

An intracerebroventricular injection of amyloid-beta peptide (1–42) aggregates modifies daily temporal organization of clock factors expression, protein carbonyls and antioxidant enzymes in the rat hippocampus

(2021) Lorena Navigatore Fonzo et al.   BRAIN RESEARCH

Mitochondrial dysfunction: A potential target for Alzheimer’s disease intervention and treatment

(2021) Jia Ke et al.   DRUG DISCOVERY TODAY

Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease

(2021) Md. Sahab Uddin et al.   NEUROCHEMICAL RESEARCH

Targeting immune dysfunction in aging

(2021) Simone Borgoni et al.   AGEING RESEARCH REVIEWS

Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

(2021) Md. Sahab Uddin et al.   AGEING RESEARCH REVIEWS

Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications

(2021) Jinwei Xie et al.   AGEING RESEARCH REVIEWS

Circadian clock genes as promising therapeutic targets for autoimmune diseases

(2021) Kun Xiang et al.   AUTOIMMUNITY REVIEWS

Hallmarks of aging and immunosenescence: Connecting the dots

(2021) Leane Perim Rodrigues et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease

(2021) Carmen Nanclares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progress towards therapies for disease modification in Parkinson's disease

(2021) Nirosen Vijiaratnam et al.   LANCET NEUROLOGY

Discovery and implications of polygenicity of common diseases

(2021) Peter M. Visscher et al.   SCIENCE

Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation

(2021) Yufei Liu et al.   Neuroscience Bulletin

Vitamin D Receptor Gene Polymorphism and Vitamin D Status in Population of Patients with Cardiovascular Disease—A Preliminary Study

(2021) Mohamed Abouzid et al.   Nutrients

Differential effects of SUMO1 and SUMO2 on circadian protein PER2 stability and function

(2021) Ling-Chih Chen et al.   Scientific Reports

Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy

(2021) Xudan Lou et al.   Scientific Reports

Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model

(2021) Eunju Kim et al.   Biomolecules

Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review

(2021) Danko Jeremic et al.   AGEING RESEARCH REVIEWS

Diversity and Regulation of Astrocyte Neurotoxicity in Alzheimer's Disease

(2021) Sadayuki Hashioka et al.   Current Alzheimer Research

A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes

(2021) Müge Yalçin et al.   Cancers

Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer’s disease and longevity in an Italian population

(2021) Maria Giulia Bacalini et al.   GeroScience

Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment

(2020) James L. Dorling et al.   AGEING RESEARCH REVIEWS

Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function

(2020) Amira A. H. Ali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1

(2020) Kifayat Ullah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice

(2020) Hitoshi Inokawa et al.   Scientific Reports

BMAL1 regulation of microglia‐mediated neuroinflammation in MPTP‐induced Parkinson's disease mouse model

(2020) Wen‐Wen Liu et al.   FASEB JOURNAL

Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis

(2020) H. Bekki et al.   OSTEOARTHRITIS AND CARTILAGE

Bright light improves sleep in patients with Parkinson’s disease: possible role of circadian restoration

(2020) Takuyuki Endo et al.   Scientific Reports

From beta amyloid to altered proteostasis in Alzheimer’s disease

(2020) Amalia C. Bruni et al.   AGEING RESEARCH REVIEWS

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

(2020) Chuqian Liang et al.   CELL RESEARCH

Parkinson’s disease: etiopathogenesis and treatment

(2020) Joseph Jankovic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?

(2020) Sang-Eun Kim et al.   Nutrients

Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction

(2020) Ana Cristina García-Gaytán et al.   Scientific Reports

NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons

(2020) Andy Tran et al.   Frontiers in Endocrinology

Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

(2020) Bhavana Chhunchha et al.   Cells

Single-cell analyses of aging, inflammation and senescence

(2020) Bora Uyar et al.   AGEING RESEARCH REVIEWS

Novel Targets for Alzheimer's Disease: A View Beyond Amyloid

(2020) William J. Ray et al.   Annual Review of Medicine

Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson’s disease

(2020) D.L. Delgado-Lara et al.   BIOMEDICINE & PHARMACOTHERAPY

Sex effects on brain structure in de novo Parkinson’s disease: a multimodal neuroimaging study

(2020) Christina Tremblay et al.   BRAIN

Adolescent sleep timing and dietary patterns in relation to DNA methylation of core circadian genes: a pilot study of Mexican youth

(2020) Erica C. Jansen et al.   Epigenetics

PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment: a 10‐year follow‐up study

(2020) V. Bessi et al.   EUROPEAN JOURNAL OF NEUROLOGY

The role of genetic polymorphism within PD-L1 gene in cancer. Review

(2020) Agnieszka Kula et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer’s Disease

(2020) Ik Dong Yoo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aging attenuates the ovarian circadian rhythm

(2020) Ziru Jiang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Targeting the epigenetic regulation of antitumour immunity

(2020) Simon J. Hogg et al.   NATURE REVIEWS DRUG DISCOVERY

REV-ERB agonism improves liver pathology in a mouse model of NASH

(2020) Kristine Griffett et al.   PLoS One

The Effect of Rev-erbα Agonist SR9011 on the Immune Response and Cell Metabolism of Microglia

(2020) Samantha E. C. Wolff et al.   Frontiers in Immunology

Defective mitophagy in Alzheimer’s disease

(2020) Jangampalli Adi Pradeepkiran et al.   AGEING RESEARCH REVIEWS

The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease

(2020) Houman Kahroba et al.   AGEING RESEARCH REVIEWS

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

(2020) Alberto Serrano-Pozo et al.   LANCET NEUROLOGY

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

(2020) Brian V. Lananna et al.   Science Translational Medicine

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

(2020) Percy Griffin et al.   eLife

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism

(2020) Xiao-Lan Wang et al.   Frontiers in Immunology

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized controlled trials

(2020) Hanna Malmberg Gavelin et al.   AGEING RESEARCH REVIEWS

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

(2020) Linli Zheng et al.   AGEING RESEARCH REVIEWS

Therapeutic effects of curcumin on age-induced alterations in daily rhythms of clock genes and Sirt1 expression in the SCN of male Wistar rats

(2019) Kowshik Kukkemane et al.   BIOGERONTOLOGY

Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila

(2019) Alex C. Boomgarden et al.   BMC GENOMICS

Inflammatory markers in Alzheimer’s disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies

(2019) Xue-Ning Shen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians – The MUGELLO Study

(2019) Giuditta Pagliai et al.   Scientific Reports

Circadian clock protein Rev-erbα regulates neuroinflammation

(2019) Percy Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB

(2019) G. Yuan et al.   OSTEOARTHRITIS AND CARTILAGE

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

(2019) Michaël E. Belloy et al.   NEURON

Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis

(2019) Steven Bradburn et al.   AGEING RESEARCH REVIEWS

Sirt6 deacetylase activity regulates circadian rhythms via Per2

(2019) Shimin Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aging renders desynchronization between clock and immune genes in male Wistar rat kidney: chronobiotic role of curcumin

(2019) Neelesh Babu Thummadi et al.   BIOGERONTOLOGY

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway

(2019) Zhengmin Ma et al.   CELL CYCLE

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

The functional changes of the circadian system organization in aging

(2019) Jia Zhao et al.   AGEING RESEARCH REVIEWS

LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging

(2019) Zhi Yang et al.   AGEING RESEARCH REVIEWS

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

(2019) Sneham Tiwari et al.   International Journal of Nanomedicine

Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes

(2019) Xintong Tan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d ‐galactose

(2019) Jing Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease

(2019) Deborah A. Roby et al.   PLoS One

Mitochondria in the signaling pathways that control longevity and health span

(2019) Mansour Akbari et al.   AGEING RESEARCH REVIEWS

The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10

(2019) Tingting Cai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Circadian regulation of astrocyte function: implications for Alzheimer’s disease

(2019) Celia A. McKee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The emerging role of epigenetic therapeutics in immuno-oncology

(2019) Michael J. Topper et al.   Nature Reviews Clinical Oncology

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Animal Models for Parkinson’s Disease Research: Trends in the 2000s

(2019) Kyohei Kin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood biomarkers with Parkinson's disease clusters and prognosis: the oxford discovery cohort

(2019) Michael Lawton et al.   MOVEMENT DISORDERS

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease

(2019) Jiyeon Lee et al.   AGING CELL

Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice

(2019) Olga Barca‐Mayo et al.   GLIA

The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease

(2018) Ji Cheng et al.   AGING CELL

Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing

(2018) Hang Lin et al.   BIOMATERIALS

Involvement of Nuclear Receptor REV-ERBβ in Formation of Neurites and Proliferation of Cultured Adult Neural Stem Cells

(2018) Koji Shimozaki   CELLULAR AND MOLECULAR NEUROBIOLOGY

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

(2018) Yu Gao et al.   Current Alzheimer Research

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain

(2018) Vaskar Das et al.   GENE

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gene expression profiling of the SCN in young and old rhesus macaques

(2018) Dominique H Eghlidi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson’s disease patients

(2018) Wei Mao et al.   NEUROSCIENCE LETTERS

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

(2018) Yali Wang et al.   Oxidative Medicine and Cellular Longevity

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics

(2018) Jan Verheijen et al.   TRENDS IN GENETICS

Light Therapy and Alzheimer's Disease and Related Dementia: Past, Present, and Future

(2018) Nicholas Hanford et al.   JOURNAL OF ALZHEIMERS DISEASE

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

(2018) Janine L. Kwapis et al.   Nature Communications

Stem Cells in Dermatology and Anti-aging Care of the Skin

(2018) Amy Forman Taub et al.   Facial Plastic Surgery Clinics of North America

Genome-wide meta-analysis identifies 3 novel loci associated with stroke

(2018) Rainer Malik et al.   ANNALS OF NEUROLOGY

Altered expression of the core circadian clock component PERIOD2 contributes to osteoarthritis-like changes in chondrocyte activity

(2018) Jing Rong et al.   CHRONOBIOLOGY INTERNATIONAL

Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

(2018) Huan Li et al.   NEUROTOXICITY RESEARCH

Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1

(2017) Guoyuan Qi et al.   FOOD AND CHEMICAL TOXICOLOGY

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

(2017) Ka Sing P Lai et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repeated manganese administration produced abnormal expression of circadian clock genes in the hypothalamus and liver of rats

(2017) Huan Li et al.   NEUROTOXICOLOGY

Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population

(2017) Eugene Lin et al.   Oncotarget

The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function

(2017) Onkar B. Sawant et al.   Cell Reports

PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

(2017) Chiara Zagni et al.   Stem Cell Reports

Positive association between physical activity and PER3 expression in older adults

(2017) Masaki Takahashi et al.   Scientific Reports

Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle

(2017) Ryan D. Welch et al.   Scientific Reports

A synopsis on aging—Theories, mechanisms and future prospects

(2016) João Pinto da Costa et al.   AGEING RESEARCH REVIEWS

Amyloid imaging: Past, present and future perspectives

(2016) Victor L. Villemagne   AGEING RESEARCH REVIEWS

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Aging does not compromise in vitro oscillation of the suprachiasmatic nuclei but makes it more vulnerable to constant light

(2016) Lenka Polidarová et al.   CHRONOBIOLOGY INTERNATIONAL

Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)

(2016) Patricia Araújo Pereira et al.   Current Alzheimer Research

Clock GeneBmal1Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1

(2016) Wei Yang et al.   ENDOCRINOLOGY

Rhythmic expression of miR-27b-3p targets the clock gene Bmal1 at the posttranscriptional level in the mouse liver

(2016) Wenxiang Zhang et al.   FASEB JOURNAL

Circadian clocks govern calorie restriction–mediated life span extension through BMAL1- and IGF-1-dependent mechanisms

(2016) Sonal A. Patel et al.   FASEB JOURNAL

Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype

(2016) Paul G. Thomes et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing

(2016) Jianwei Wang et al.   NATURE CELL BIOLOGY

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization

(2016) Laura K. Fonken et al.   NEUROBIOLOGY OF AGING

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

The circadian clock gene period extends healthspan in aging Drosophila melanogaster

(2016) Natraj Krishnan et al.   Aging-US

The Polymorphism of CLOCK Gene 3111T/C C>T Is Associated With Susceptibility of Alzheimer Disease in Chinese Population

(2016) Yun-Kang Yang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

(2016) Rui-Hong Wang et al.   Scientific Reports

Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice

(2015) Amira A. H. Ali et al.   Aging-US

Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation

(2015) Kevin A. Ingle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

(2015) Hyundong Song et al.   Molecular Neurodegeneration

Tipping the metabolic scales towards increased longevity in mammals

(2015) Celine E. Riera et al.   NATURE CELL BIOLOGY

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of miR-182 in regulating pineal CLOCK expression after hypoxia-ischemia brain injury in neonatal rats

(2015) Xin Ding et al.   NEUROSCIENCE LETTERS

Overexpression of the Circadian Clock GeneRev-erbαAffects Murine Bone Mesenchymal Stem Cell Proliferation and Osteogenesis

(2015) Yao He et al.   STEM CELLS AND DEVELOPMENT

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese

(2015) Zhuqin Gu et al.   Scientific Reports

Ageing and osteoarthritis: a circadian rhythm connection

(2014) Nicole Gossan et al.   BIOGERONTOLOGY

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Differential modulation of clock gene expression in the suprachiasmatic nucleus, liver and heart of aged mice

(2014) Marta Bonaconsa et al.   EXPERIMENTAL GERONTOLOGY

Novel role of nuclear receptor rev-erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury

(2014) Ting Li et al.   HEPATOLOGY

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

(2014) David P. Breen et al.   JAMA Neurology

Polymorphism of CLOCK Gene rs 4580704 C>G Is Associated with Susceptibility of Alzheimer’s Disease in a Chinese Population

(2013) Hai-feng Chen et al.   ARCHIVES OF MEDICAL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

A Circadian Clock Gene, Rev-erb , Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression

(2013) S. Sato et al.   JOURNAL OF IMMUNOLOGY

Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population

(2013) Qian Chen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Bmal1 and  -Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced  -Cell Failure in Mice

(2013) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease

(2013) Akane Hayashi et al.   NEUROMOLECULAR MEDICINE

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

Role of miR-142-3p in the Post-Transcriptional Regulation of the Clock Gene Bmal1 in the Mouse SCN

(2013) Vikram R. Shende et al.   PLoS One

Common Genetic Variants in ARNTL and NPAS2 and at Chromosome 12p13 are Associated with Objectively Measured Sleep Traits in the Elderly

(2013) Daniel S. Evans et al.   SLEEP

Deviation of innate circadian period from 24 h reduces longevity in mice

(2012) Sergiy Libert et al.   AGING CELL

A common polymorphism nearPER1and the timing of human behavioral rhythms

(2012) Andrew S. P. Lim et al.   ANNALS OF NEUROLOGY

Mammalian PER2 regulates AKT activation and DNA damage response

(2012) Xiaoming Yang et al.   Biochemistry and Cell Biology

Stem cell heterogeneity: implications for aging and regenerative medicine

(2012) C. E. Muller-Sieburg et al.   BLOOD

Over-expression of circadian clock geneBmal1affects proliferation and the canonical Wnt pathway in NIH-3T3 cells

(2012) Fuwei Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity

(2012) Adam C. Silver et al.   IMMUNITY

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The circadian clock and pathology of the ageing brain

(2012) Anna A. Kondratova et al.   NATURE REVIEWS NEUROSCIENCE

A historical justification for and retrospective analysis of the systematic application of light therapy in Parkinson’s disease

(2012) Gregory L. Willis et al.   REVIEWS IN THE NEUROSCIENCES

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Circadian clock protein BMAL1 regulates cellular senescence in vivo

(2011) Rohini V. Khapre et al.   CELL CYCLE

Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects

(2011) Nicolas Cermakian et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Age-Related Decline in Circadian Output

(2011) T. J. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

(2011) Natraj Krishnan et al.   NEUROBIOLOGY OF DISEASE

Sleep and Sleep Disorders in Older Adults

(2011) Kate Crowley   NEUROPSYCHOLOGY REVIEW

Decreased expression of Bmal2 in patients with Parkinson's disease

(2011) Hui Ding et al.   NEUROSCIENCE LETTERS

Promoter methylation analysis of seven clock genes in Parkinson's disease

(2011) Qingling Lin et al.   NEUROSCIENCE LETTERS

A Molecular Mechanism for Circadian Clock Negative Feedback

(2011) H. A. Duong et al.   SCIENCE

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

(2010) Cathy A. Wyse et al.   BRAIN RESEARCH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Expression of clock genesPer1andBmal1in total leukocytes in health and Parkinson’s disease

(2009) Y. Cai et al.   EUROPEAN JOURNAL OF NEUROLOGY

Loss of cryptochrome reduces cancer risk inp53mutant mice

(2009) Nuri Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY

Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells

(2008) Tomomi Kimiwada et al.   NEUROCHEMISTRY INTERNATIONAL