Neuroinflammation: the devil is in the details

GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations

(2016) Karol Ramirez et al.   BRAIN BEHAVIOR AND IMMUNITY

Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge

(2016) Megan M. Muccigrosso et al.   BRAIN BEHAVIOR AND IMMUNITY

A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in Adults

(2016) Rongzi Shan et al.   JOURNAL OF NEUROTRAUMA

Delayed Methylene Blue Improves Lesion Volume, Multi-Parametric Quantitative Magnetic Resonance Imaging Measurements, and Behavioral Outcome after Traumatic Brain Injury

(2016) Lora Talley Watts et al.   JOURNAL OF NEUROTRAUMA

Widespread microglial activation in patients deceased from traumatic brain injury

(2015) Antonio Velázquez et al.   BRAIN INJURY

Aquaporins and blood–brain barrier permeability in early edema development after traumatic brain injury

(2015) Jonas Blixt et al.   BRAIN RESEARCH

Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury

(2015) Bei Zhang et al.   EXPERIMENTAL NEUROLOGY

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury

(2015) Bei Zhang et al.   Journal of Neuroinflammation

IL-1  Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3

(2015) D. Bastien et al.   JOURNAL OF NEUROSCIENCE

Axon Initial Segment-Associated Microglia

(2015) K. Baalman et al.   JOURNAL OF NEUROSCIENCE

CCR2 Antagonism Alters Brain Macrophage Polarization and Ameliorates Cognitive Dysfunction Induced by Traumatic Brain Injury

(2015) J. M. Morganti et al.   JOURNAL OF NEUROSCIENCE

Methylene Blue Attenuates Traumatic Brain Injury-Associated Neuroinflammation and Acute Depressive-Like Behavior in Mice

(2015) Ashley M. Fenn et al.   JOURNAL OF NEUROTRAUMA

Chronic Histopathological and Behavioral Outcomes of Experimental Traumatic Brain Injury in Adult Male Animals

(2015) Nicole D. Osier et al.   JOURNAL OF NEUROTRAUMA

Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain

(2015) C.M. Sawicki et al.   NEUROSCIENCE

Cerebrospinal Fluid Markers of Macrophage and Lymphocyte Activation After Traumatic Brain Injury in Children

(2015) Elizabeth Newell et al.   Pediatric Critical Care Medicine

Immune Surveillance of the CNS following Infection and Injury

(2015) Matthew V. Russo et al.   TRENDS IN IMMUNOLOGY

Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury

(2015) Kristina G. Witcher et al.   TRENDS IN NEUROSCIENCES

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Remote effects on the striatal dopamine system after fluid percussion injury

(2014) Eagle Yi-Kung Huang et al.   BEHAVIOURAL BRAIN RESEARCH

Kinetic characteristics of euflammation: The induction of controlled inflammation without overt sickness behavior

(2014) Andrew J. Tarr et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

(2014) Diana M. Norden et al.   GLIA

Repeated Mild Traumatic Brain Injury Causes Chronic Neuroinflammation, Changes in Hippocampal Synaptic Plasticity, and Associated Cognitive Deficits

(2014) Stephanie L Aungst et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Macrophagic and microglial responses after focal traumatic brain injury in the female rat

(2014) L Turtzo et al.   Journal of Neuroinflammation

Microglia of Prefrontal White Matter in Suicide

(2014) Tatiana P. Schnieder et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Chronic variable stress activates hematopoietic stem cells

(2014) Timo Heidt et al.   NATURE MEDICINE

Injury timing alters metabolic, inflammatory and functional outcomes following repeated mild traumatic brain injury

(2014) Zachary M. Weil et al.   NEUROBIOLOGY OF DISEASE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model

(2013) Benoit C. Mouzon et al.   ANNALS OF NEUROLOGY

Re-establishment of Anxiety in Stress-Sensitized Mice Is Caused by Monocyte Trafficking from the Spleen to the Brain

(2013) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Immune Activation Promotes Depression 1 Month After Diffuse Brain Injury: A Role for Primed Microglia

(2013) Ashley M. Fenn et al.   BIOLOGICAL PSYCHIATRY

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning

(2013) Adriana del Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin

(2013) Keith W. Kelley et al.   BRAIN BEHAVIOR AND IMMUNITY

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

(2013) Dorothy P. Schafer et al.   CURRENT OPINION IN NEUROBIOLOGY

Training innate immunity: the changing concept of immunological memory in innate host defence

(2013) Mihai G. Netea   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Minocycline plus N-acetylcysteine synergize to modulate inflammation and prevent cognitive and memory deficits in a rat model of mild traumatic brain injury

(2013) Margalit Haber et al.   EXPERIMENTAL NEUROLOGY

Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast

(2013) P.M. Abdul-Muneer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Norepinephrine Modulates the Motility of Resting and Activated Microglia via Different Adrenergic Receptors

(2013) Stefka Gyoneva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion

(2013) Sandy R Shultz et al.   Journal of Neuroinflammation

Progressive Neurodegeneration After Experimental Brain Trauma

(2013) David J. Loane et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The p38  MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury

(2013) A. D. Bachstetter et al.   JOURNAL OF NEUROSCIENCE

Elevated MMP-9 in the Lumbar Cord Early after Thoracic Spinal Cord Injury Impedes Motor Relearning in Mice

(2013) C. N. Hansen et al.   JOURNAL OF NEUROSCIENCE

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

(2013) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via  -adrenergic induction of myelopoiesis

(2013) N. D. Powell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging

(2013) Elias Gebara et al.   Frontiers in Neuroscience

The Role of Markers of Inflammation in Traumatic Brain Injury

(2013) Thomas Woodcock et al.   Frontiers in Neurology

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

(2012) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice

(2012) Angela W. Corona et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of phospholipase A2s and lipid mediators in secondary damage after spinal cord injury

(2012) Samuel David et al.   CELL AND TISSUE RESEARCH

Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury

(2012) Jenna M Ziebell et al.   Journal of Neuroinflammation

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

(2012) Alok Kumar et al.   NEUROBIOLOGY OF AGING

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Interleukin-1R3 mediates interleukin-1–induced potassium current increase through fast activation of Akt kinase

(2012) Jiang Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice

(2012) Eric S. Wohleb et al.   PSYCHONEUROENDOCRINOLOGY

Acute Minocycline Treatment Mitigates the Symptoms of Mild Blast-Induced Traumatic Brain Injury

(2012) Erzsebet Kovesdi et al.   Frontiers in Neurology

Phagocytic Clearance in Neurodegeneration

(2011) Jennifer D. Sokolowski et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

Beneficial Effect of Interleukin-1 Receptor Antagonist Protein on Spinal Cord Injury Recovery in the Rat

(2011) Shaohui Zong et al.   INFLAMMATION

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Does Caring for a Spouse with Dementia Promote Cognitive Decline? A Hypothesis and Proposed Mechanisms

(2011) Peter P. Vitaliano et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

(2010) Angela M. Wynne et al.   BRAIN BEHAVIOR AND IMMUNITY

Cytokine levels in the blood may distinguish suicide attempters from depressed patients

(2010) Shorena Janelidze et al.   BRAIN BEHAVIOR AND IMMUNITY

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

(2010) Heidi A. Jurgens et al.   EXPERIMENTAL NEUROLOGY

Role of CCL2 (MCP-1) in Traumatic Brain Injury (TBI): Evidence from Severe TBI Patients and CCL2−/− Mice

(2010) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Involvement of nitric oxide in lipopolysaccharide induced anorexia

(2010) Thomas Riediger et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats

(2009) Karine Palin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Characterization of the sickness response in young and aging rats following E. coli infection

(2009) Ruth M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion

(2009) Isabelle Pineau et al.   BRAIN BEHAVIOR AND IMMUNITY

Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity

(2009) J. C. Gensel et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Cellular and molecular actions of Methylene Blue in the nervous system

(2009) Murat Oz et al.   MEDICINAL RESEARCH REVIEWS

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

How (and why) the immune system makes us sleep

(2009) Luca Imeri et al.   NATURE REVIEWS NEUROSCIENCE

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Consuming a Diet Supplemented with Resveratrol Reduced Infection-Related Neuroinflammation and Deficits in Working Memory in Aged Mice

(2009) Jayne Abraham et al.   REJUVENATION RESEARCH

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

(2008) Ruth M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

Neuroinflammation and cognitive function in aged mice following minor surgery

(2008) H.A. Rosczyk et al.   EXPERIMENTAL GERONTOLOGY

An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury

(2008) Feng Bao et al.   EXPERIMENTAL NEUROLOGY

Interleukin-1 (IL-1): A central regulator of stress responses

(2008) Inbal Goshen et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Requirement of Myeloid Cells for Axon Regeneration

(2008) B. Barrette et al.   JOURNAL OF NEUROSCIENCE

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNF -Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

(2008) A. R. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

Evidence for a cytokine model of cognitive function

(2008) J. McAfoose et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice

(2008) J.B. Buchanan et al.   PSYCHONEUROENDOCRINOLOGY

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

(2007) Jing Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

(2007) Y. Huang et al.   NEUROBIOLOGY OF AGING

Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120

(2006) J. Abraham et al.   NEUROBIOLOGY OF AGING