A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update

(2021) Karim Fifel et al.   Frontiers in Neuroscience

Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson’s disease and their targeted therapeutic approaches: a comprehensive review

(2021) Tapan Behl et al.   Translational Neurodegeneration

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration

(2021) Gregory J. Gillispie et al.   Life-Basel

Clocking cancer: the circadian clock as a target in cancer therapy

(2021) Francesca Battaglin et al.   ONCOGENE

Understanding the Multiple Role of Mitochondria in Parkinson’s Disease and Related Disorders: Lesson From Genetics and Protein–Interaction Network

(2021) Valentina Nicoletti et al.   Frontiers in Cell and Developmental Biology

A Multi‐Step Model of Parkinson's Disease Pathogenesis

(2021) Campbell Le Heron et al.   MOVEMENT DISORDERS

CHG: A Systematically Integrated Database of Cancer Hallmark Genes

(2020) Denan Zhang et al.   Frontiers in Genetics

A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson’s disease

(2020) Thomas B Stoker et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Sleep, circadian rhythms and health

(2020) Russell G. Foster   Interface Focus

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease

(2020) Müge Yalçin et al.   Cancers

Association of Circadian Abnormalities in Older Adults With an Increased Risk of Developing Parkinson Disease

(2020) Yue Leng et al.   JAMA Neurology

A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target

(2020) Andrea Ghelli Luserna di Rorà et al.   Journal of Hematology & Oncology

An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling

(2020) Janina Hesse et al.   Cancers

The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

(2020) Günther Deuschl et al.   Lancet Public Health

Circadian Dysregulation of the TGFβ/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells

(2020) Yin Li et al.   iScience

Cancer and Parkinson's Disease: Common Targets, Emerging Hopes

(2020) Panagiota S. Filippou et al.   MOVEMENT DISORDERS

Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia

(2020) Kathryn Lanza et al.   EXPERIMENTAL NEUROLOGY

Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review

(2019) Klaus Seppi et al.   MOVEMENT DISORDERS

Polo-like kinase 3 is associated with poor prognosis and regulates proliferation and metastasis in prostate cancer

(2019) Chunhao Lin et al.   Cancer Management and Research

New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx

(2019) Mohamed Mounir et al.   PLoS Computational Biology

Pharmacogenetic Profile and the Occurrence of Visual Hallucinations in Patients With Sporadic Parkinson's Disease

(2019) Erinaldo Ubirajara Damasceno dos Santos et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Neuropsychiatric aspects of Parkinson’s disease

(2019) Anna Nagy et al.   JOURNAL OF NEURAL TRANSMISSION

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

(2019) Wai Hoong Chang et al.   Journal of Translational Medicine

GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic Approaches

(2019) Giulietta M. Riboldi et al.   Cells

Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism

(2019) Consiglia Pacelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes

(2019) Fuhr et al.   Cancers

A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events

(2019) Rukeia El-Athman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toward understanding the origin and evolution of cellular organisms

(2019) Minoru Kanehisa   PROTEIN SCIENCE

Association between Parkinson’s Disease and Risk of Cancer: A PRISMA-compliant Meta-analysis

(2019) Pengcheng Zhang et al.   ACS Chemical Neuroscience

Assessing the role of nocturnal core body temperature dysregulation as a biomarker of neurodegeneration

(2019) Arabella K. Raupach et al.   JOURNAL OF SLEEP RESEARCH

Molecular mechanisms and physiological importance of circadian rhythms

(2019) Alina Patke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy lysosomal pathway dysfunction in Parkinson's disease; evidence from human genetics

(2019) Konstantin Senkevich et al.   PARKINSONISM & RELATED DISORDERS

Molecular crosstalk between cancer and neurodegenerative diseases

(2019) Jiyeon Seo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Disturbances of Sleep and Alertness in Parkinson’s Disease

(2018) Aleksandar Videnovic   Current Neurology and Neuroscience Reports

The overexpression of PXN promotes tumor progression and leads to radioresistance in cervical cancer

(2018) Qiuli Liu et al.   Future Oncology

Getting a good night sleep? The importance of recognizing and treating nocturnal hypokinesia in Parkinson’s disease

(2018) Roongroj Bhidayasiri et al.   PARKINSONISM & RELATED DISORDERS

The spectrum of “off” in Parkinson's disease: What have we learned over 40 years?

(2018) Kelvin L. Chou et al.   PARKINSONISM & RELATED DISORDERS

CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease

(2018) Fan Lou et al.   Parkinsons Disease

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer

(2018) Luise Fuhr et al.   EBioMedicine

Time to Check the Clock in Cardiovascular Research and Medicine

(2018) David Montaigne et al.   CIRCULATION RESEARCH

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

The reciprocal interplay between TNFα and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells

(2018) Mónica Abreu et al.   Scientific Reports

Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back

(2018) Federica De Lazzari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Emerging Evidence of the Parkinson Pandemic

(2018) E. Ray Dorsey et al.   Journal of Parkinsons Disease

The aging clock: circadian rhythms and later life

(2017) Suzanne Hood et al.   JOURNAL OF CLINICAL INVESTIGATION

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Analysis of blood-based gene expression in idiopathic Parkinson disease

(2017) Ron Shamir et al.   NEUROLOGY

The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor-associated genes in human oral squamous cell carcinoma

(2017) Xiaoli Su et al.   ONCOLOGY REPORTS

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

(2017) Lama M. Chahine et al.   SLEEP MEDICINE REVIEWS

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Bioinformatics analysis to screen the key prognostic genes in ovarian cancer

(2017) Li Li et al.   Journal of Ovarian Research

Glucocerebrosidase Mutations in Parkinson Disease

(2017) Grace O’Regan et al.   Journal of Parkinsons Disease

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity

(2017) Rukeia El-Athman et al.   PLOS BIOLOGY

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

(2017) Laura Civiero et al.   Frontiers in Molecular Neuroscience

Role of LRRK2 in the regulation of dopamine receptor trafficking

(2017) Mauro Rassu et al.   PLoS One

Circulating VEGF and eNOS variations as predictors of outcome in metastatic colorectal cancer patients receiving bevacizumab

(2017) Giorgia Marisi et al.   Scientific Reports

Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay

(2016) Rosella Scrima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos

(2016) Olga Cela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Differential rhythmicity: detecting altered rhythmicity in biological data

(2016) Paul F. Thaben et al.   BIOINFORMATICS

Visual dysfunction in Parkinson’s disease

(2016) Rimona S. Weil et al.   BRAIN

Alterations of the circadian system in Parkinson's disease patients

(2016) Karim Fifel   MOVEMENT DISORDERS

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

A New Perspective for Parkinson’s Disease: Circadian Rhythm

(2016) Siyue Li et al.   Neuroscience Bulletin

Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies

(2016) Hye-Jin Park et al.   Annals of Clinical and Translational Neurology

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

(2015) Joseph J. Locascio et al.   BRAIN

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

(2015) Laura Civiero et al.   JOURNAL OF NEUROCHEMISTRY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data

(2015) Antonio Colaprico et al.   NUCLEIC ACIDS RESEARCH

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese

(2015) Zhuqin Gu et al.   Scientific Reports

Circadian systems biology: When time matters

(2015) Luise Fuhr et al.   Computational and Structural Biotechnology Journal

Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach

(2015) Robert Lehmann et al.   PLoS One

PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy

(2015) Jian Chen et al.   Oncotarget

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Premotor and nonmotor features of Parkinsonʼs disease

(2014) Jennifer G. Goldman et al.   CURRENT OPINION IN NEUROLOGY

Induction of GADD45α protects M17 neuroblastoma cells against MPP*

(2014) Xiao-Feng Wang et al.   IUBMB LIFE

Detecting Rhythms in Time Series with RAIN

(2014) Paul F. Thaben et al.   JOURNAL OF BIOLOGICAL RHYTHMS

'The clocks that time us'—circadian rhythms in neurodegenerative disorders

(2014) Aleksandar Videnovic et al.   Nature Reviews Neurology

Disturbances in melatonin secretion and circadian sleep–wake regulation in Parkinson disease

(2014) S.J. Bolitho et al.   SLEEP MEDICINE

Rhythmic Degradation Explains and Unifies Circadian Transcriptome and Proteome Data

(2014) Sarah Lück et al.   Cell Reports

Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses

(2014) Kristina Ibáñez et al.   PLoS Genetics

Ras-Mediated Deregulation of the Circadian Clock in Cancer

(2014) Angela Relógio et al.   PLoS Genetics

Circadian Melatonin Rhythm and Excessive Daytime Sleepiness in Parkinson Disease

(2014) Aleksandar Videnovic et al.   JAMA Neurology

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

(2014) David P. Breen et al.   JAMA Neurology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The hallmarks of Parkinson's disease

(2013) Paul M. A. Antony et al.   FEBS Journal

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

(2013) Bernard M. H. Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death

(2013) Raul E. Salinas et al.   MOLECULAR BIOLOGY OF THE CELL

Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue

(2013) Mária Štorcelová et al.   MOLECULAR BIOLOGY REPORTS

“Sleep benefit” in Parkinson's disease: A systematic review

(2013) Merel M. van Gilst et al.   PARKINSONISM & RELATED DISORDERS

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Twenty-Four Hour Non-Invasive Ambulatory Blood Pressure and Heart Rate Monitoring in Parkinson’s Disease

(2013) Eva Stuebner et al.   Frontiers in Neurology

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

GADD45 Proteins: Central Players in Tumorigenesis

(2012) R. E. Tamura et al.   CURRENT MOLECULAR MEDICINE

An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors

(2012) Matúš Soták et al.   INTERNATIONAL JOURNAL OF CANCER

Sleep and Parkinson's disease: A review of case-control polysomnography studies

(2012) Tasneem Peeraully et al.   MOVEMENT DISORDERS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

NONO couples the circadian clock to the cell cycle

(2012) E. Kowalska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tef polymorphism is associated with sleep disturbances in patients with Parkinson’s disease

(2012) Ping Hua et al.   SLEEP MEDICINE

Recent Advances in the Genetics of Parkinson's Disease

(2011) Ian Martin et al.   Annual Review of Genomics and Human Genetics

Circadian rhythm of rest activity and autonomic nervous system activity at different stages in Parkinson's disease

(2011) Fumitoshi Niwa et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Diurnal Secretion Profiles of Growth Hormone, Thyrotrophin and Prolactin in Parkinson’s Disease

(2011) N. A. Aziz et al.   JOURNAL OF NEUROENDOCRINOLOGY

No paradox, no progress: inverse cancer comorbidity in people with other complex diseases

(2011) Rafael Tabarés-Seisdedos et al.   LANCET ONCOLOGY

Decreased expression of Bmal2 in patients with Parkinson's disease

(2011) Hui Ding et al.   NEUROSCIENCE LETTERS

Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops

(2011) Angela Relógio et al.   PLoS Computational Biology

Assessment of response fluctuations in Parkinson's disease by ambulatory wrist activity monitoring

(2010) J. J. Hilten et al.   ACTA NEUROLOGICA SCANDINAVICA

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Circadian clock control of the cellular response to DNA damage

(2010) Aziz Sancar et al.   FEBS LETTERS

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea

(2010) Hélène Plun-Favreau et al.   PLoS Genetics

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Expression of clock genesPer1andBmal1in total leukocytes in health and Parkinson’s disease

(2009) Y. Cai et al.   EUROPEAN JOURNAL OF NEUROLOGY

Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

(2009) Raymond C.S. Seet et al.   FREE RADICAL BIOLOGY AND MEDICINE

arrayQualityMetrics—a bioconductor package for quality assessment of microarray data

(2008) Audrey Kauffmann et al.   BIOINFORMATICS

Nitric oxide synthase genes and their interactions with environmental factors in Parkinson’s disease

(2008) Dana B. Hancock et al.   NEUROGENETICS

p73 Regulates Neurodegeneration and Phospho-Tau Accumulation during Aging and Alzheimer's Disease

(2008) Monica K. Wetzel et al.   NEURON

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease

(2008) Jan Gründemann et al.   NUCLEIC ACIDS RESEARCH

Multiple pathways regulated by the tumor suppressor PP2A in transformation

(2008) Jukka Westermarck et al.   TRENDS IN MOLECULAR MEDICINE