Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration

(2020) Brian V. Lananna et al.   NEUROBIOLOGY OF DISEASE

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

(2019) Jorge L. Del-Aguila et al.   Alzheimers Research & Therapy

Assessment of the Genetic Architecture of Alzheimer’s Disease Risk in Rate of Memory Decline

(2018) Jorge L. Del-Aguila et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

(2018) Erik S. Musiek et al.   JAMA Neurology

K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

(2018) Ji Yeon Choi et al.   Journal of Neuroinflammation

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum

(2018) Ignacio Illán-Gala et al.   NEUROLOGY

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1

(2018) Brian V. Lananna et al.   Cell Reports

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

(2017) Marta Querol-Vilaseca et al.   Journal of Neuroinflammation

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

(2017) Franc Llorens et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration

(2017) Daniel Alcolea et al.   NEUROLOGY

Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40

(2016) Yuetiva Deming et al.   BMC Neurology

The intrinsic microglial clock system regulates interleukin-6 expression

(2016) Ryota Nakazato et al.   GLIA

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Microglia inflammatory responses are controlled by an intrinsic circadian clock

(2015) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

RelB/p50 Complexes Regulate Cytokine-Induced YKL-40 Expression

(2015) Reetika Bhardwaj et al.   JOURNAL OF IMMUNOLOGY

Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age

(2015) Courtney L. Sutphen et al.   JAMA Neurology

Circadian Clock Proteins and Immunity

(2014) Anne M. Curtis et al.   IMMUNITY

CSF levels of YKL-40 are increased in MS and decrease with immunosuppressive treatment

(2014) Clas Malmeström et al.   JOURNAL OF NEUROIMMUNOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Role for mammalian chitinase 3-like protein 1 in traumatic brain injury

(2014) Clayton A. Wiley et al.   NEUROPATHOLOGY

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2

(2013) Chuan Hua He et al.   Cell Reports

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Chitinase 3-like-1 Promotes Streptococcus pneumoniae Killing and Augments Host Tolerance to Lung Antibacterial Responses

(2012) Charles S. Dela Cruz et al.   Cell Host & Microbe

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

Exacerbation of Experimental Autoimmune Encephalomyelitis in the Absence of Breast Regression Protein 39/Chitinase 3-Like 1

(2012) Dafna Bonneh-Barkay et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

(2009) Chun Geun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE