Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

Circadian clock protein Rev-erbα regulates neuroinflammation

(2019) Percy Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment

(2019) Taylor R. Jay et al.   GLIA

TREM2 function impedes tau seeding in neuritic plaques

(2019) Cheryl E. G. Leyns et al.   NATURE NEUROSCIENCE

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease

(2019) Deborah A. Roby et al.   PLoS One

Microglia-mediated synaptic pruning is impaired in sleep-deprived adolescent mice

(2019) Li-Heng Tuan et al.   NEUROBIOLOGY OF DISEASE

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

(2018) Marie Pariollaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

(2018) Erik S. Musiek et al.   JAMA Neurology

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

(2018) Meng-meng Jin et al.   Frontiers in Aging Neuroscience

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

Regulating the Suprachiasmatic Nucleus (SCN) Circadian Clockwork: Interplay between Cell-Autonomous and Circuit-Level Mechanisms

(2017) Erik D. Herzog et al.   Cold Spring Harbor Perspectives in Biology

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

(2017) Tian Zhou et al.   Frontiers in Neuroanatomy

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases

(2017) Gyun Jee Song et al.   Frontiers in Aging Neuroscience

Amyloid-β–Induced Changes in Molecular Clock Properties and Cellular Bioenergetics

(2017) Karen Schmitt et al.   Frontiers in Neuroscience

Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade

(2017) Changbin Zhu et al.   Acta Neuropathologica Communications

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Microglia inflammatory responses are controlled by an intrinsic circadian clock

(2015) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

The dynamics of monocytes and microglia in Alzheimer’s disease

(2015) Peter Thériault et al.   Alzheimers Research & Therapy

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

(2014) Jee Hoon Roh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

(2014) Deborah Doens et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα

(2014) Shogo Sato et al.   TheScientificWorldJOURNAL

Nuclear receptor Rev-erbα: up, down, and all around

(2014) Logan J. Everett et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

(2013) Michael T. Y. Lam et al.   NATURE

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

(2013) Estelle Woldt et al.   NATURE MEDICINE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The Circadian System in Alzheimer’s Disease: Disturbances, Mechanisms, and Opportunities

(2012) Andrew N. Coogan et al.   BIOLOGICAL PSYCHIATRY

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Circadian autophagy rhythm: a link between clock and metabolism?

(2012) Di Ma et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Selective Upregulation of Per1 mRNA Expression by ATP Through Activation of P2X7 Purinergic Receptors Expressed in Microglial Cells

(2011) Ryota Nakazato et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators

(2011) Jennifer A. Mohawk et al.   TRENDS IN NEUROSCIENCES

Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

(2010) Douglas Kojetin et al.   ACS Chemical Biology

Glial cell modulation of circadian rhythms

(2010) F. Rob Jackson   GLIA

A circadian clock in macrophages controls inflammatory immune responses

(2009) Maren Keller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE