Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

The Role of the Syk/Shp-1 Kinase-Phosphatase Equilibrium in B Cell Development and Signaling

(2014) A. Alsadeq et al.   JOURNAL OF IMMUNOLOGY

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

(2014) Margarida A. Santos et al.   NATURE

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

(2012) Jianwei Wang et al.   CELL

Immunoaging induced by hematopoietic stem cell aging

(2011) Jianwei Wang et al.   CURRENT OPINION IN IMMUNOLOGY

Analysis of the Role of IL-21 in Development of Murine B Cell Progenitors in the Bone Marrow

(2011) N. Simard et al.   JOURNAL OF IMMUNOLOGY

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

(2011) Andre Limnander et al.   NATURE IMMUNOLOGY

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcutaneous Infection with S. aureus in Mice Reveals Association of Resistance with Influx of Neutrophils and Th2 Response

(2010) Nadine Nippe et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

(2010) Susie Lee et al.   PLoS One

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice

(2009) Z. Song et al.   BLOOD

Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

(2009) V. M. Vassin et al.   JOURNAL OF CELL SCIENCE

Aging in the lympho-hematopoietic stem cell compartment

(2009) Hartmut Geiger et al.   TRENDS IN IMMUNOLOGY

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

(2008) R. H. Cho et al.   BLOOD

Telomere maintenance and human bone marrow failure

(2008) R. T. Calado et al.   BLOOD

Hematopoietic Stem Cells and the Aging Hematopoietic System

(2008) Roi Gazit et al.   SEMINARS IN HEMATOLOGY