Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease

Dissecting Sex-Related Cognition between Alzheimer’s Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies

(2021) Ghulam Md Ashraf et al.   Oxidative Medicine and Cellular Longevity

Biological signatures of Alzheimer Disease

(2020) Poornima Sharma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Combination Drug Therapy for the Management of Alzheimer’s Disease

(2020) Md. Tanvir Kabir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Estrogen Signaling in Alzheimer’s Disease: Molecular Insights and Therapeutic Targets for Alzheimer’s Dementia

(2020) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

(2020) Sholpan Askarova et al.   Frontiers in Cellular and Infection Microbiology

Circadian and sleep dysfunction in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   AGEING RESEARCH REVIEWS

Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years

(2020) Joseph R. Winer et al.   CURRENT BIOLOGY

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multicenter Study on Sleep and Circadian Alterations as Objective Markers of Mild Cognitive Impairment and Alzheimer’s Disease Reveals Sex Differences

(2020) Biancamaria Guarnieri et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease

(2019) Brendan P. Lucey et al.   Science Translational Medicine

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort

(2019) Ping Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology

(2019) Md. Farhad Hossain et al.   MOLECULAR NEUROBIOLOGY

REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output

(2019) Ryosuke Ikeda et al.   Scientific Reports

The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer′s Disease (AD)

(2019) Mroczko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiome diversity is associated with sleep physiology in humans

(2019) Robert P. Smith et al.   PLoS One

Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep

(2019) Mercedes Arnes et al.   Frontiers in Aging Neuroscience

Interactions between sleep disturbances and Alzheimer’s disease on brain function: a preliminary study combining the static and dynamic functional MRI

(2019) Kaicheng Li et al.   Scientific Reports

Circadian Rhythms Disturbances in Alzheimer Disease

(2018) Ángela Milán-Tomás et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics

(2018) Brendan P. Lucey et al.   ANNALS OF NEUROLOGY

Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

(2018) Kurt A. Jellinger et al.   BMC Medicine

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition

(2018) Jessica A. Deaver et al.   Frontiers in Microbiology

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

(2018) Erik S. Musiek et al.   JAMA Neurology

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

(2018) Leonardo Iaccarino et al.   NeuroImage-Clinical

Field Measurements of Light Exposures and Circadian Disruption in Two Populations of Older Adults

(2018) Mariana G. Figueiro et al.   JOURNAL OF ALZHEIMERS DISEASE

Disruption of normal circadian clock function in a mouse model of tauopathy

(2017) Korey Stevanovic et al.   EXPERIMENTAL NEUROLOGY

Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders

(2017) Agnes Nadjar et al.   Frontiers in Cellular Neuroscience

A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms

(2017) Michael Rosbash   Cold Spring Harbor Perspectives in Biology

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

(2017) Olga Barca-Mayo et al.   Nature Communications

The role of melatonin in the onset and progression of type 3 diabetes

(2017) Juhyun Song et al.   Molecular Brain

Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits

(2016) Kaitlin H. Snider et al.   BEHAVIOURAL BRAIN RESEARCH

The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease

(2016) Cristiano Köhler et al.   CURRENT PHARMACEUTICAL DESIGN

Chronomedicine and type 2 diabetes: shining some light on melatonin

(2016) Andrew C. Forrestel et al.   DIABETOLOGIA

Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer’s Disease-Like Pathologies in AβPPswe/PS1ΔE9 Mice

(2016) Hongyan Qiu et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Aberrant Axonal Arborization of PDF Neurons Induced by Aβ42-Mediated JNK Activation Underlies Sleep Disturbance in an Alzheimer’s Model

(2016) Qian Song et al.   MOLECULAR NEUROBIOLOGY

Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly

(2016) Andrew W. Varga et al.   SLEEP

Circadian Rhythms, Sleep, and Disorders of Aging

(2016) Joanna Mattis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator

(2016) J. Patrick Pett et al.   PLoS Computational Biology

Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly

(2016) Andrew W. Varga et al.   SLEEP

The Polymorphism of CLOCK Gene 3111T/C C>T Is Associated With Susceptibility of Alzheimer Disease in Chinese Population

(2016) Yun-Kang Yang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

(2015) Christian Benedict et al.   Alzheimers & Dementia

Melanopsin retinal ganglion cell loss in Alzheimer disease

(2015) Chiara La Morgia et al.   ANNALS OF NEUROLOGY

Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability

(2015) Masashi Tabuchi et al.   CURRENT BIOLOGY

Sleep and Cognitive Decline: A Strong Bidirectional Relationship. It Is Time for Specific Recommendations on Routine Assessment and the Management of Sleep Disorders in Patients with Mild Cognitive Impairment and Dementia

(2015) Biancamaria Guarnieri et al.   EUROPEAN NEUROLOGY

Daytime somnolence as an early sign of cognitive decline in a community-based study of older people

(2015) Angeliki Tsapanou et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Circadian timing of metabolism in animal models and humans

(2015) C. Dibner et al.   JOURNAL OF INTERNAL MEDICINE

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

(2015) Hyundong Song et al.   Molecular Neurodegeneration

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock

(2015) Xue Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt

(2015) Aalim M. Weljie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep and Alzheimer's disease

(2015) Laure Peter-Derex et al.   SLEEP MEDICINE REVIEWS

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency

(2014) Li-You Chen et al.   Brain Structure & Function

Impact of sleep on the risk of cognitive decline and dementia

(2014) Adam P. Spira et al.   CURRENT OPINION IN PSYCHIATRY

Circadian disruption in the pathogenesis of metabolic syndrome

(2014) E. Maury et al.   DIABETES & METABOLISM

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease

(2014) K.-F. Chen et al.   Disease Models & Mechanisms

The light-dark cycle controls peripheral rhythmicity in mice with a genetically ablated suprachiasmatic nucleus clock

(2014) Jana Husse et al.   FASEB JOURNAL

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Relationships between the Circadian System and Alzheimer's Disease-Like Symptoms in Drosophila

(2014) Dani M. Long et al.   PLoS One

Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men

(2014) Sharon Ooms et al.   JAMA Neurology

Melanopsin retinal ganglion cells and circadian dysfunction in Alzheimer´s disease

(2013) C LA MORGIA et al.   ACTA OPHTHALMOLOGICA

A Change in Sleep Pattern May Predict Alzheimer Disease

(2013) Elizabeth A. Hahn et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

The therapeutics of Alzheimer's disease: Where we stand and where we are heading

(2013) Dennis J. Selkoe   ANNALS OF NEUROLOGY

Polymorphism of CLOCK Gene rs 4580704 C>G Is Associated with Susceptibility of Alzheimer’s Disease in a Chinese Population

(2013) Hai-feng Chen et al.   ARCHIVES OF MEDICAL RESEARCH

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Melatonin in Alzheimer’s Disease

(2013) Li Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin: Buffering the Immune System

(2013) Antonio Carrillo-Vico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population

(2013) Qian Chen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Sleep and Alzheimer disease pathology—a bidirectional relationship

(2013) Yo-El S. Ju et al.   Nature Reviews Neurology

Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study

(2013) S. Yasar et al.   NEUROLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons

(2013) Andrew S. P. Lim et al.   SLEEP

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

(2013) Géraldine Rauchs et al.   Frontiers in Behavioral Neuroscience

Cognitive dysfunction, elevated anxiety, and reduced cocaine response in circadian clock-deficient cryptochrome knockout mice

(2013) Dimitri De Bundel et al.   Frontiers in Behavioral Neuroscience

Self-reported Sleep and β-Amyloid Deposition in Community-Dwelling Older Adults

(2013) Adam P. Spira et al.   JAMA Neurology

Modification of the Relationship of the Apolipoprotein E ε4 Allele to the Risk of Alzheimer Disease and Neurofibrillary Tangle Density by Sleep

(2013) Andrew S. P. Lim et al.   JAMA Neurology

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

β-Amyloid Dynamics in Human Plasma

(2012) Yafei Huang et al.   ARCHIVES OF NEUROLOGY

The Circadian System in Alzheimer’s Disease: Disturbances, Mechanisms, and Opportunities

(2012) Andrew N. Coogan et al.   BIOLOGICAL PSYCHIATRY

Sleep disturbance induces neuroinflammation and impairment of learning and memory

(2012) Biao Zhu et al.   NEUROBIOLOGY OF DISEASE

Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

(2012) J. H. Roh et al.   Science Translational Medicine

Sleep Quality and 1-Year Incident Cognitive Impairment in Community-Dwelling Older Adults

(2012) Olivier Potvin et al.   SLEEP

Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women

(2011) Gregory J. Tranah et al.   ANNALS OF NEUROLOGY

PET/CT in diagnosis of dementia

(2011) Valentina Berti et al.   Annals of the New York Academy of Sciences

Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System

(2011) Yafei Huang   ARCHIVES OF NEUROLOGY

Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women

(2011) Kristine Yaffe et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Circadian Regulation of ATP Release in Astrocytes

(2011) L. Marpegan et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Regional Slow Waves and Spindles in Human Sleep

(2011) Yuval Nir et al.   NEURON

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

(2010) Cathy A. Wyse et al.   BRAIN RESEARCH

The memory function of sleep

(2010) Susanne Diekelmann et al.   NATURE REVIEWS NEUROSCIENCE

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Is there a link between sleep changes and memory in Alzheimerʼs disease?

(2010) Géraldine Rauchs et al.   NEUROREPORT

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour

(2009) Louisa M-C Wang et al.   ASN Neuro

Vascular Disease in Mice With a Dysfunctional Circadian Clock

(2009) Ciprian B. Anea et al.   CIRCULATION

Temporal dynamics of mouse hippocampal clock gene expression support memory processing

(2009) Antje Jilg et al.   HIPPOCAMPUS

Usual sleep duration and cognitive function in older adults in Spain

(2009) RAQUEL FAUBEL et al.   JOURNAL OF SLEEP RESEARCH

Brain perfusion SPECT with an automated quantitative tool can identify prodromal Alzheimer's disease among patients with mild cognitive impairment

(2009) Marie-Odile Habert et al.   NEUROBIOLOGY OF AGING

Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker

(2009) Kun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia

(2008) D. G. Harper et al.   BRAIN

Circadian Time-Place Learning in Mice Depends on Cry Genes

(2008) Eddy A. Van der Zee et al.   CURRENT BIOLOGY

Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease

(2008) Bruce A. Yankner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY