Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease

Astrocytes and Behavior

(2021) Paulo Kofuji et al.   Annual Review of Neuroscience

Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease

(2021) Kun Leng et al.   NATURE NEUROSCIENCE

Serum d-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker

(2021) Luciano Piubelli et al.   Translational Psychiatry

Contribution of astrocytes to neuropathology of neurodegenerative diseases

(2021) Cigdem Acioglu et al.   BRAIN RESEARCH

Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca2+ alteration and multiphasic transmitter release

(2021) Cuong Pham et al.   Acta Neuropathologica Communications

Astroglial Connexins in Neurodegenerative Diseases

(2021) Xiaomin Huang et al.   Frontiers in Molecular Neuroscience

Astrocyte Diversity: Current Insights and Future Directions

(2020) Thomas Westergard et al.   NEUROCHEMICAL RESEARCH

Reactive Astrocytes as Therapeutic Targets for Brain Degenerative Diseases: Roles Played by Metabotropic Glutamate Receptors

(2020) Talia M. Planas-Fontánez et al.   NEUROCHEMICAL RESEARCH

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

(2020) Paulo Kofuji et al.   NEUROSCIENCE

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

Astrocytes modulate sensory-evoked neuronal network activity

(2020) Justin Lines et al.   Nature Communications

d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders

(2020) Herman Wolosker et al.   Translational Psychiatry

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Altered Expression of Glial Gap Junction Proteins Cx43, Cx30, and Cx47 in the 5XFAD Model of Alzheimer’s Disease

(2020) Stella Angeli et al.   Frontiers in Neuroscience

The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases

(2020) Alison C. Todd et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors

(2020) Sara Mederos et al.   NATURE NEUROSCIENCE

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

(2019) LingYan Xing et al.   Frontiers in Molecular Neuroscience

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

(2019) Edward Pajarillo et al.   NEUROPHARMACOLOGY

GABAergic astrocytes in Alzheimer’s disease

(2019) Olga Garaschuk et al.   Aging-US

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

(2019) Darrick T. Balu et al.   NEUROBIOLOGY OF DISEASE

Human astrocytes in the diseased brain

(2018) Elena Dossi et al.   BRAIN RESEARCH BULLETIN

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

(2018) Marc Fakhoury   Current Neuropharmacology

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

(2018) Nicole Reichenbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease

(2018) Upasana Roy et al.   NEUROBIOLOGY OF AGING

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

Glial function (and dysfunction) in the normal & ischemic brain

(2018) Shino D. Magaki et al.   NEUROPHARMACOLOGY

Reactive astrocytes in Alzheimer’s disease: A double-edged sword

(2018) Heejung Chun et al.   NEUROSCIENCE RESEARCH

Functional Astrocyte Heterogeneity and Implications for Their Role in Shaping Neurotransmission

(2018) Wendy Xin et al.   Frontiers in Cellular Neuroscience

Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain

(2018) Eiji Kobayashi et al.   Scientific Reports

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies

(2018) Paula Garcia-Esparcia et al.   Frontiers in Aging Neuroscience

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

Diversity of Astroglial Effects on Aging- and Experience-Related Cortical Metaplasticity

(2018) Ulyana Lalo et al.   Frontiers in Molecular Neuroscience

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

(2018) Paramita Mookherjee et al.   JOURNAL OF ALZHEIMERS DISEASE

Picomolar Amyloid-β Peptides Enhance Spontaneous Astrocyte Calcium Transients

(2018) Linda Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Diversity and Specificity of Astrocyte–neuron Communication

(2018) Caitlin A. Durkee et al.   NEUROSCIENCE

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

(2018) Yuji Kajiwara et al.   Acta Neuropathologica Communications

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

(2017) Stefano Tarantini et al.   EXPERIMENTAL GERONTOLOGY

Neuron-astrocyte signaling is preserved in the aging brain

(2017) Marta Gómez-Gonzalo et al.   GLIA

Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission

(2017) Ciaran Murphy-Royal et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors

(2017) M Jun et al.   MOLECULAR PSYCHIATRY

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Risk factors associated with the onset and progression of Alzheimer’s disease: A systematic review of the evidence

(2017) Mona Hersi et al.   NEUROTOXICOLOGY

Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN)

(2017) Adrienn Kovács et al.   Frontiers in Cellular Neuroscience

Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice

(2017) Oliver Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

(2017) Jose Viña et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of glial-specific Kir4.1 in normal and pathological states of the CNS

(2016) Sinifunanya E. Nwaobi et al.   ACTA NEUROPATHOLOGICA

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

(2016) C Yi et al.   CELL DEATH AND DIFFERENTIATION

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism

(2016) Rosario Gajardo-Gómez et al.   GLIA

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Astrocytic mGluR5 and the tripartite synapse

(2016) A. Panatier et al.   NEUROSCIENCE

Astrocytes: Orchestrating synaptic plasticity?

(2016) M. De Pittà et al.   NEUROSCIENCE

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Astrocytes regulate cortical state switching in vivo

(2016) Kira E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

(2016) J. K. Hefendehl et al.   Nature Communications

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

(2016) Gertrudis Perea et al.   eLife

Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain

(2016) Kazuki Harada et al.   Frontiers in Neuroscience

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

(2015) R. Martin et al.   SCIENCE

Do stars govern our actions? Astrocyte involvement in rodent behavior

(2015) João Filipe Oliveira et al.   TRENDS IN NEUROSCIENCES

Molecular approaches for manipulating astrocytic signaling in vivo

(2015) Alison X. Xie et al.   Frontiers in Cellular Neuroscience

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

(2015) C Madeira et al.   Translational Psychiatry

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Astrocytes and neuroinflammation in Alzheimer's disease

(2014) Emma C. Phillips et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

P2Y receptors in Alzheimer's disease

(2014) Laurie Erb et al.   BIOLOGY OF THE CELL

Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition

(2014) Bo-Eun Yoon et al.   JOURNAL OF PHYSIOLOGY-LONDON

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Astrocytes contribute to gamma oscillations and recognition memory

(2014) H. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABA as a rising gliotransmitter

(2014) Bo-Eun Yoon et al.   Frontiers in Neural Circuits

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

(2014) Ulyana Lalo et al.   PLOS BIOLOGY

Astrocytes revisited: concise historic outlook on glutamate homeostasis and signaling

(2013) Vladimir Parpura et al.   CROATIAN MEDICAL JOURNAL

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

D-serine as a gliotransmitter and its roles in brain development and disease

(2013) Marion R. Van Horn et al.   Frontiers in Cellular Neuroscience

The role of astrocytes in amyloid β-protein toxicity and clearance

(2012) Dietmar Rudolf Thal   EXPERIMENTAL NEUROLOGY

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

(2012) Sylvia O. Suadicani et al.   GLIA

Astrocyte-Originated ATP Protects A 1-42-Induced Impairment of Synaptic Plasticity

(2012) E. S. Jung et al.   JOURNAL OF NEUROSCIENCE

Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research

(2012) Christine L. Carter et al.   JOURNAL OF WOMENS HEALTH

Astrocyte signaling controls spike timing–dependent depression at neocortical synapses

(2012) Rogier Min et al.   NATURE NEUROSCIENCE

Aβ leads to Ca2+ signaling alterations and transcriptional changes in glial cells

(2012) Ambra A. Grolla et al.   NEUROBIOLOGY OF AGING

Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes

(2012) Cendra Agulhon et al.   Frontiers in Pharmacology

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

(2011) H. Rheinallt Parri et al.   BIOCHEMICAL PHARMACOLOGY

Glial connexin expression and function in the context of Alzheimer's disease

(2011) Annette Koulakoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

(2011) Aude Panatier et al.   CELL

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Triggers Exocytosis from Two Types of Organelles in a Single Astrocyte

(2011) T. Liu et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Reimagining Alzheimer's Disease--An Age-Based Hypothesis

(2010) K. Herrup   JOURNAL OF NEUROSCIENCE

Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes

(2010) Marta Navarrete et al.   NEURON

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

(2009) Christopher S. Casley et al.   BRAIN RESEARCH

Gliotransmission: Exocytotic release from astrocytes

(2009) Vladimir Parpura et al.   BRAIN RESEARCH REVIEWS

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Functional implications for Kir4.1 channels in glial biology: from K+buffering to cell differentiation

(2008) Michelle L. Olsen et al.   JOURNAL OF NEUROCHEMISTRY

Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-Mediated Slow Inward Currents in Pyramidal Neurons

(2008) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

(2008) Scott A. Small et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Synaptic modulation by astrocytes via Ca2+-dependent glutamate release

(2008) M. Santello et al.   NEUROSCIENCE

ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear

(2008) F. Anselmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE