The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease

Hormesis and Ginkgo biloba (GB): Numerous biological effects of GB are mediated via hormesis

(2020) Edward J. Calabrese et al.   AGEING RESEARCH REVIEWS

MiRNA-137-mediated modulation of mitochondrial dynamics regulates human neural stem cell fate

(2020) Asha S. Channakkar et al.   STEM CELLS

Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases

(2020) Houman Kahroba et al.   BIOCHIMIE

Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

(2020) Giovanni Brunetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polydatin promotes the neuronal differentiation of bone marrow mesenchymal stem cells in vitro and in vivo: Involvement of Nrf2 signalling pathway

(2020) Jiheng Zhan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tetramethylpyrazine enhanced the therapeutic effects of human umbilical cord mesenchymal stem cells in experimental autoimmune encephalomyelitis mice through Nrf2/HO-1 signaling pathway

(2020) Lianshuang Zhang et al.   Stem Cell Research & Therapy

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models

(2020) Gabriele Di Rosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro

(2020) Qingyue Liu et al.   LIFE SCIENCES

Complete neural stem cell (NSC) neuronal differentiation requires a branched chain amino acids-induced persistent metabolic shift towards energy metabolism

(2020) Francesco Bifari et al.   PHARMACOLOGICAL RESEARCH

DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability

(2020) Behnaz banimohamad-shotorbani et al.   AGEING RESEARCH REVIEWS

Anti-inflammatory and Anti-oxidant Activity of Hidrox® in Rotenone-Induced Parkinson’s Disease in Mice

(2020) Rosalba Siracusa et al.   Antioxidants

Monitoring the Redox Status in Multiple Sclerosis

(2020) Masaru Tanaka et al.   Biomedicines

MicroRNA-146b-5p protects oligodendrocyte precursor cells from oxygen/glucose deprivation-induced injury through regulating Keap1/Nrf2 signaling via targeting bromodomain-containing protein 4

(2019) Xiaoquan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Nrf2/STAT3 axis in induction of apoptosis through sub‐G 1 cell cycle arrest mechanism in HT‐29 colon cancer cells

(2019) Issa Tajmohammadi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation

(2019) Jia-Wen Shou et al.   Frontiers in Cellular Neuroscience

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson’s Disease Cell Models

(2019) Pei-Cih Wei et al.   Oxidative Medicine and Cellular Longevity

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

(2019) Xiaozhen Dai et al.   TRENDS IN MOLECULAR MEDICINE

The Role of Nrf2 signaling in cancer stem cells: From stemness and self-renewal to tumorigenesis and chemoresistance

(2019) Houman Kahroba et al.   LIFE SCIENCES

Neuroinflammation in Huntington’s Disease: New Insights with 11C-PBR28 PET/MRI

(2018) Cristina Lois et al.   ACS Chemical Neuroscience

Redox Signaling Mechanisms in Nervous System Development

(2018) Mauricio Olguín-Albuerne et al.   ANTIOXIDANTS & REDOX SIGNALING

Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells

(2018) Mohammed A. El-Magd et al.   BIOMEDICINE & PHARMACOTHERAPY

A Role for Nrf2 Expression in Defining the Aging of Hippocampal Neural Stem Cells

(2018) S. Ray et al.   CELL TRANSPLANTATION

Oxidative Stress and Cancer: The Role of Nrf2

(2018) Soraya Sajadimajd et al.   CURRENT CANCER DRUG TARGETS

The role of Nrf2 signaling in counteracting neurodegenerative diseases

(2018) Albena T. Dinkova-Kostova et al.   FEBS Journal

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

(2018) Vittorio Calabrese et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside

(2018) Ravikanth Velagapudi et al.   MOLECULAR NEUROBIOLOGY

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress

(2018) Ming-Chang Chiang et al.   NEUROCHEMISTRY INTERNATIONAL

Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition

(2018) F Sarubbo et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

(2018) Wei Cai et al.   PROGRESS IN NEUROBIOLOGY

High Glucose Inhibits Neural Stem Cell Differentiation Through Oxidative Stress and Endoplasmic Reticulum Stress

(2018) Xi Chen et al.   STEM CELLS AND DEVELOPMENT

Neural stem cell therapy for subacute and chronic ischemic stroke

(2018) Austin C. Boese et al.   Stem Cell Research & Therapy

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

(2018) Vittorio Calabrese et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Parkinson Disease

(2018) Stephen G. Reich et al.   MEDICAL CLINICS OF NORTH AMERICA

Targeted hyaluronic acid-based lipid nanoparticle for apigenin delivery to induce Nrf2-dependent apoptosis in lung cancer cells

(2018) Shiva Mahmoudi et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

The role of oxidative stress in Friedreich's ataxia

(2017) Federica Lupoli et al.   FEBS LETTERS

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways

(2017) Junfeng Yu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain-Derived Neurotrophic Factor Increases Synaptic Protein Levels via the MAPK/Erk Signaling Pathway and Nrf2/Trx Axis Following the Transplantation of Neural Stem Cells in a Rat Model of Traumatic Brain Injury

(2017) Tao Chen et al.   NEUROCHEMICAL RESEARCH

Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes

(2017) Francesca Pistollato et al.   NEUROCHEMISTRY INTERNATIONAL

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

(2017) Luisa Quinti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells

(2017) Zohreh Mostafavi-Pour et al.   Oncology Letters

Oxidative stress promotes exit from the stem cell state and spontaneous neuronal differentiation

(2017) Qidong Hu et al.   Oncotarget

Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus

(2017) Natalia Robledinos-Antón et al.   Redox Biology

Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period

(2016) Mandi J. Corenblum et al.   AGING CELL

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children

(2016) Peter J. Wagner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Tetramethylpyrazine induces differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells in vitro

(2016) CHENGRUI NAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells

(2016) Yumin Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Resveratrol pretreatment attenuates injury and promotes proliferation of neural stem cells following oxygen-glucose deprivation/reoxygenation by upregulating the expression of Nrf2, HO-1 and NQO1 in vitro

(2016) Changbo Shen et al.   Molecular Medicine Reports

Neuroprotective Effects of Theaflavins Against Oxidative Stress-Induced Apoptosis in PC12 Cells

(2016) Jing Zhang et al.   NEUROCHEMICAL RESEARCH

Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway

(2016) Xiaohong Yang et al.   NEUROSCIENCE LETTERS

Neural stem cells injured by oxidative stress can be rejuvenated by GV1001, a novel peptide, through scavenging free radicals and enhancing survival signals

(2016) Hyun-Hee Park et al.   NEUROTOXICOLOGY

Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells

(2016) Tingting Dou et al.   Oxidative Medicine and Cellular Longevity

Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds

(2016) Isabel Denzer et al.   PHARMACOLOGICAL RESEARCH

Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks

(2016) Edward J. Calabrese   PHARMACOLOGICAL RESEARCH

Therapeutic potential of human olfactory bulb neural stem cells for spinal cord injury in rats

(2016) H E Marei et al.   SPINAL CORD

Optimal ROS Signaling Is Critical for Nuclear Reprogramming

(2016) Gang Zhou et al.   Cell Reports

NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming

(2016) Kate E. Hawkins et al.   Cell Reports

MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression

(2015) Savan Kabaria et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway

(2015) Qin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death

(2015) Amrita Datta Chaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular commitment in the developing cerebellum

(2015) Hassan Marzban et al.   Frontiers in Cellular Neuroscience

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells

(2014) Catarina C.F. Homem et al.   CELL

Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency

(2014) Julie Mathieu et al.   Cell Stem Cell

Stem cells and the impact of ROS signaling

(2014) C. L. Bigarella et al.   DEVELOPMENT

Mechanisms of white matter damage in multiple sclerosis

(2014) Hans Lassmann   GLIA

Human Olfactory Bulb Neural Stem Cells expressing hNGF Restore Cognitive Deficit in Alzheimer's Disease Rat Model

(2014) Hany E. S. Marei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-7 Protects against 1-Methyl-4-Phenylpyridinium-Induced Cell Death by Targeting RelA

(2014) D. C. Choi et al.   JOURNAL OF NEUROSCIENCE

Omega-3 Polyunsaturated Fatty Acids Protect Neural Progenitor Cells against Oxidative Injury

(2014) Qiang Liu et al.   Marine Drugs

Evaluation of Lovastatin Effects on Expression of Anti-apoptotic Nrf2 and PGC-1α Genes in Neural Stem Cells Treated with Hydrogen Peroxide

(2014) Alireza Abdanipour et al.   MOLECULAR NEUROBIOLOGY

Ginsenoside Rb1 Protects Rat Neural Progenitor Cells against Oxidative Injury

(2014) Na Ni et al.   MOLECULES

Efficacy and safety of delayed-release dimethyl fumarate in patients newly diagnosed with relapsing–remitting multiple sclerosis (RRMS)

(2014) Ralf Gold et al.   Multiple Sclerosis Journal

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Nrf2 Regulates Neurogenesis and Protects Neural Progenitor Cells Against Aβ Toxicity

(2014) Virve Kärkkäinen et al.   STEM CELLS

Frataxin Deficiency Leads to Defects in Expression of Antioxidants and Nrf2 Expression in Dorsal Root Ganglia of the Friedreich's Ataxia YG8R Mouse Model

(2013) Yuxi Shan et al.   ANTIOXIDANTS & REDOX SIGNALING

Doxycycline can stimulate cytoprotection in neural stem cells with oxygen–glucose deprivation–reoxygenation injury: A potential approach to enhance effectiveness of cell transplantation therapy

(2013) Yousra Saeed Malik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The fumaric acid ester BG-12: a new option in MS therapy

(2013) De-Hyung Lee et al.   Expert Review of Neurotherapeutics

Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons

(2013) Valentina D'Oria et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The patients with clinically isolated syndrome and relapsing remitting multiple sclerosis show different levels of advanced protein oxidation products and total thiol content in plasma and CSF

(2013) Srdjan Ljubisavljevic et al.   NEUROCHEMISTRY INTERNATIONAL

BG-12 in Multiple Sclerosis

(2013) Robert Fox et al.   SEMINARS IN NEUROLOGY

Systematic screen for genes involved in the regulation of oxidative stress in the nematode Caenorhabditis elegans

(2012) Shunsuke Ueno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective effects of incensole acetate on cerebral ischemic injury

(2012) Arieh Moussaieff et al.   BRAIN RESEARCH

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

(2012) Marc Thier et al.   Cell Stem Cell

Resveratrol, A Neuroprotective Supplement for Alzheimer's Disease

(2012) Fei Li et al.   CURRENT PHARMACEUTICAL DESIGN

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Minocycline-Preconditioned Neural Stem Cells Enhance Neuroprotection after Ischemic Stroke in Rats

(2012) H. Sakata et al.   JOURNAL OF NEUROSCIENCE

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Iron–sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia

(2012) Rachael A. Vaubel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Synthetic Condensed 1,4-naphthoquinone Derivative Shifts Neural Stem Cell Differentiation by Regulating Redox State

(2012) Daniela M. Santos et al.   MOLECULAR NEUROBIOLOGY

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem cell technology for neurodegenerative diseases

(2011) J. Simon Lunn et al.   ANNALS OF NEUROLOGY

Resveratrol and apoptosis

(2011) Hung-Yun Lin et al.   Annals of the New York Academy of Sciences

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1

(2011) Shao Xia Lin et al.   ASN Neuro

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Doxycycline-Mediated Protective Effect Against Focal Cerebral Ischemia–Reperfusion Injury Through the Modulation of Tight Junctions and PKCδ Signaling in Rats

(2011) Zhenhua Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

(2011) Trent M Woodruff et al.   Molecular Neurodegeneration

Gene Expression Profiling of Embryonic Human Neural Stem Cells and Dopaminergic Neurons from Adult Human Substantia Nigra

(2011) Hany E. S. Marei et al.   PLoS One

Pathology and pathogenesis of sensory neuropathy in Friedreich’s ataxia

(2010) Jennifer A. Morral et al.   ACTA NEUROPATHOLOGICA

Friedreich Ataxia: Molecular Mechanisms, Redox Considerations, and Therapeutic Opportunities

(2010) Renata Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro

(2010) Hailan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

(2010) Hong-Quan Wang et al.   BRAIN RESEARCH

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathophysiology of inflammation and tissue injury in multiple sclerosis: What are the targets for therapy

(2010) Hans Lassmann   JOURNAL OF THE NEUROLOGICAL SCIENCES

Tetramethylpyrazine promotes proliferation and differentiation of neural stem cells from rat brain in hypoxic condition via mitogen-activated protein kinases pathway in vitro

(2010) Yumei Tian et al.   NEUROSCIENCE LETTERS

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy metabolism in adult neural stem cell fate

(2010) Victoria A. Rafalski et al.   PROGRESS IN NEUROBIOLOGY

The potential of neural stem cells to repair stroke-induced brain damage

(2009) Yi Ping Liu et al.   ACTA NEUROPATHOLOGICA

Fumaric Acid and its Esters: An Emerging Treatment for Multiple Sclerosis

(2009) D. Moharregh-Khiabani et al.   Current Neuropharmacology

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

(2009) Steven G. Kernie et al.   NEUROBIOLOGY OF DISEASE

Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy

(2009) Marcel M Daadi et al.   Regenerative Medicine

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

(2008) M Alba Sorolla et al.   FREE RADICAL BIOLOGY AND MEDICINE

The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair

(2008) Agnieszka Arthur et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Incensole Acetate: A Novel Neuroprotective Agent Isolated from Boswellia Carterii

(2008) Arieh Moussaieff et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Generation of human-induced pluripotent stem cells

(2008) In-Hyun Park et al.   Nature Protocols

Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia

(2008) P. R. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA