Mechanisms linking circadian clocks, sleep, and neurodegeneration

Altered CSF Orexin and α-Synuclein Levels in Dementia Patients

(2018) Malin Wennström et al.   JOURNAL OF ALZHEIMERS DISEASE

The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish

(2016) Guodong Huang et al.   Autophagy

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

(2016) Guangrui Yang et al.   Science Translational Medicine

Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects

(2016) Ricardo S. Osorio et al.   SLEEP

Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects

(2016) Ricardo S. Osorio et al.   SLEEP

Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice

(2015) Amira A. H. Ali et al.   Aging-US

Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

(2015) Christian Benedict et al.   Alzheimers & Dementia

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

(2015) Alpar S. Lazar et al.   ANNALS OF NEUROLOGY

Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans

(2015) Joshua L. Wang et al.   ANNALS OF NEUROLOGY

Microglia inflammatory responses are controlled by an intrinsic circadian clock

(2015) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population

(2015) Q. Chen et al.   GENETICS AND MOLECULAR RESEARCH

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men

(2015) Jonathan Cedernaes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

(2015) Hyundong Song et al.   Molecular Neurodegeneration

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

(2015) Bryce A Mander et al.   NATURE NEUROSCIENCE

Circadian control of innate immunity in macrophages by miR-155 targetingBmal1

(2015) Anne M. Curtis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Imaging of the Central and Peripheral Effects of Sleep Deprivation and Suprachiasmatic Nuclei Lesion on PERIOD-2 Protein in Mice

(2015) Thomas Curie et al.   SLEEP

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese

(2015) Zhuqin Gu et al.   Scientific Reports

Misaligned feeding impairs memories

(2015) Dawn H Loh et al.   eLife

In Vivo Imaging of the Central and Peripheral Effects of Sleep Deprivation and Suprachiasmatic Nuclei Lesion on PERIOD-2 Protein in Mice

(2015) Thomas Curie et al.   SLEEP

A time to remember: The role of circadian clocks in learning and memory.

(2014) Benjamin L. Smarr et al.   BEHAVIORAL NEUROSCIENCE

Circadian modulation of proteasome activities and removal of carbonylated proteins

(2014) Audrey Desvergne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

(2014) Jee Hoon Roh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extended Wakefulness: Compromised Metabolics in and Degeneration of Locus Ceruleus Neurons

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

'The clocks that time us'—circadian rhythms in neurodegenerative disorders

(2014) Aleksandar Videnovic et al.   Nature Reviews Neurology

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration

(2014) Giulio Tononi et al.   NEURON

Survival of Adult Generated Hippocampal Neurons Is Altered in Circadian Arrhythmic Mice

(2014) Brooke D. Rakai et al.   PLoS One

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Sleep Deprivation Increases Serum Levels of Neuron-Specific Enolase (NSE) and S100 Calcium Binding Protein B (S-100B) in Healthy Young Men

(2014) Christian Benedict et al.   SLEEP

Circadian Melatonin Rhythm and Excessive Daytime Sleepiness in Parkinson Disease

(2014) Aleksandar Videnovic et al.   JAMA Neurology

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

(2014) David P. Breen et al.   JAMA Neurology

Polymorphism of CLOCK Gene rs 4580704 C>G Is Associated with Susceptibility of Alzheimer’s Disease in a Chinese Population

(2013) Hai-feng Chen et al.   ARCHIVES OF MEDICAL RESEARCH

Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

(2013) Sarah M. Rothman et al.   BRAIN RESEARCH

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

(2013) Atish Mukherji et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Sleep Disturbance is Associated with Incident Dementia and Mortality

(2013) Roxanne Sterniczuk et al.   Current Alzheimer Research

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

(2013) K. D. Nguyen et al.   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons

(2013) Andrew S. P. Lim et al.   SLEEP

Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series

(2013) Carlos H. Schenck et al.   SLEEP MEDICINE

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

(2013) Yoshinori Hayashi et al.   Scientific Reports

The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit

(2013) Pascale Bouchard-Cannon et al.   Cell Reports

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Circadian Oscillations of Molecular Clock Components in the Cerebellar Cortex of the Rat

(2012) Martin F. Rath et al.   CHRONOBIOLOGY INTERNATIONAL

Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome

(2012) Markus Stratmann et al.   MOLECULAR CELL

Peroxiredoxins are conserved markers of circadian rhythms

(2012) Rachel S. Edgar et al.   NATURE

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

(2012) Laura M. Beaver et al.   PLoS One

Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons

(2012) T. A. Wang et al.   SCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

(2012) J. H. Roh et al.   Science Translational Medicine

Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women

(2011) Gregory J. Tranah et al.   ANNALS OF NEUROLOGY

Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System

(2011) Yafei Huang   ARCHIVES OF NEUROLOGY

Circadian clock protein BMAL1 regulates cellular senescence in vivo

(2011) Rohini V. Khapre et al.   CELL CYCLE

Temporal orchestration of circadian autophagy rhythm by C/EBPβ

(2011) Di Ma et al.   EMBO JOURNAL

Circadian dysfunction in a mouse model of Parkinson's disease

(2011) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects

(2011) Nicolas Cermakian et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Age-Related Decline in Circadian Output

(2011) T. J. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Sleep Loss Reduces the DNA-Binding of BMAL1, CLOCK, and NPAS2 to Specific Clock Genes in the Mouse Cerebral Cortex

(2011) Valérie Mongrain et al.   PLoS One

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of circadian clocks has ramifications for metabolism, brain, and behavior

(2011) I. N. Karatsoreos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

(2010) Cathy A. Wyse et al.   BRAIN RESEARCH

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

(2010) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

(2010) O. Castanon-Cervantes et al.   JOURNAL OF IMMUNOLOGY

Disruption of Peripheral Circadian Timekeeping in a Mouse Model of Huntington's Disease and Its Restoration by Temporally Scheduled Feeding

(2010) E. S. Maywood et al.   JOURNAL OF NEUROSCIENCE

Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters

(2010) Erin M. Gibson et al.   PLoS One

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Expression of clock genesPer1andBmal1in total leukocytes in health and Parkinson’s disease

(2009) Y. Cai et al.   EUROPEAN JOURNAL OF NEUROLOGY

A circadian clock in macrophages controls inflammatory immune responses

(2009) Maren Keller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor

(2008) H. Reinke et al.   GENES & DEVELOPMENT

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities

(2008) Rixt F. Riemersma-van der Lek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE