Mitochondrial dysfunction: A potential target for Alzheimer’s disease intervention and treatment

Mitochondrial dysfunction, insulin resistance and potential genetic implications

(2020) Panjamaporn Sangwung et al.   ENDOCRINOLOGY

Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease

(2020) Hui Zhou et al.   BIOMATERIALS

The role of mitochondrial impairment on Alzheimer´s disease neurodegeneration: the Tau connection

(2020) Rodrigo A. Quntanilla et al.   Current Neuropharmacology

Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease

(2020) Monique Patricio Singulani et al.   EXPERIMENTAL GERONTOLOGY

Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells

(2020) Dominic D. Quintana et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin mediated novel therapies for the treatment of Alzheimer's disease

(2020) Sunil Kumar Dubey et al.   LIFE SCIENCES

Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease

(2020) Sachchida Nand Rai et al.   MOLECULAR NEUROBIOLOGY

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

(2020) Kai Kaarniranta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases

(2020) Xixi Zhang et al.   Aging-US

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

(2020) Zoe Arvanitakis et al.   ANNALS OF NEUROLOGY

Can nicotinamide riboside protect against cognitive impairment?

(2020) Nady Braidy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Long-term oral melatonin alleviates memory deficits, reduces amyloid-β deposition associated with downregulation of BACE1 and mitophagy in APP/PS1 transgenic mice

(2020) Cuimei Sun et al.   NEUROSCIENCE LETTERS

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

(2020) Ryohei Iwata et al.   SCIENCE

Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease

(2020) D. Allan Butterfield et al.   Antioxidants

Curcumin Formulations and Trials: What’s New in Neurological Diseases

(2020) Stella Gagliardi et al.   MOLECULES

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

(2019) Fabio Di Domenico et al.   Redox Biology

Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury

(2019) Zhonglong Liu et al.   Cell Death & Disease

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

(2019) Matt Kaeberlein et al.   Science Translational Medicine

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

The role of mitochondrial defects and oxidative stress in Alzheimer’s disease

(2019) Badar ul Islam et al.   JOURNAL OF DRUG TARGETING

ApoE4: an emerging therapeutic target for Alzheimer’s disease

(2019) Mirna Safieh et al.   BMC Medicine

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

(2019) Pierre Dourlen et al.   ACTA NEUROPATHOLOGICA

Rapamycin and Alzheimer disease: a double-edged sword?

(2019) Julian M Carosi et al.   Autophagy

Autophagy dysfunction in Alzheimer’s disease: mechanistic insights and new therapeutic opportunities

(2019) Antonio Di Meco et al.   BIOLOGICAL PSYCHIATRY

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

(2019) Giovanna Cenini et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dynamics and transport in Alzheimer's disease

(2019) Padraig J. Flannery et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondria and the Brain: Bioenergetics and Beyond

(2019) Pascale Belenguer et al.   NEUROTOXICITY RESEARCH

Alzheimer’s disease: Key developments support promising perspectives for therapy

(2019) Jacopo Meldolesi   PHARMACOLOGICAL RESEARCH

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

(2019) Candice E. Van Skike et al.   AGING CELL

Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer's disease models

(2019) Zhan Zhang et al.   AGING CELL

Differential activation of the mTOR/autophagy pathway predicts cognitive performance in APP/PS1 mice

(2019) Rasika S. Vartak et al.   NEUROBIOLOGY OF AGING

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

Mitochondrial calcium signaling as a therapeutic target for Alzheimer’s disease

(2019) Aston Jiaxi Wu et al.   Current Alzheimer Research

KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis

(2019) Xu Qian et al.   MOLECULAR CELL

Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease

(2018) Qing Chen et al.   ACS Nano

The mitochondrial ATP synthase is a shared drug target for aging and dementia

(2018) Joshua Goldberg et al.   AGING CELL

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

(2018) Thomas Goiran et al.   BIOLOGICAL PSYCHIATRY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

(2018) IsaacG Onyango   Neural Regeneration Research

Nutraceuticals: An emerging therapeutic approach against the pathogenesis of Alzheimer’s disease

(2018) Pritam Sadhukhan et al.   PHARMACOLOGICAL RESEARCH

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

(2018) Carola Rotermund et al.   Frontiers in Endocrinology

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives

(2018) Gantumur Battogtokh et al.   Acta Pharmaceutica Sinica B

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity

(2018) Xiao-Ping Li et al.   Neural Regeneration Research

Mitochondrial Pharmacology of Dimebon (Latrepirdine) Calls for a New Look at its Possible Therapeutic Potential in Alzheimer’s Disease

(2018) Schamim H Eckert et al.   Aging and Disease

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

(2018) María José Pérez et al.   Redox Biology

Accuracy and generalization capability of an automatic method for the detection of typical brain hypometabolism in prodromal Alzheimer disease

(2018) Fabrizio De Carli et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Mitochondrial dynamics, a key executioner in neurodegenerative diseases

(2018) Komal Panchal et al.   MITOCHONDRION

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

(2017) Xin Liu et al.   NATURE CELL BIOLOGY

Resveratrol ameliorates spatial learning memory impairment induced by Aβ 1–42 in rats

(2017) Rui Wang et al.   NEUROSCIENCE

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease

(2017) Walter E. Müller et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Dimebon (Latrepirdine) Enhances Mitochondrial Function and Protects Neuronal Cells from Death

(2017) Shouting Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Pioglitazone prevents tau oligomerization

(2016) Tadanori Hamano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism

(2016) Jana Hroudová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pioglitazone for the treatment of Alzheimer’s disease

(2016) Daniela Galimberti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease

(2016) Isaura V.A. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

(2016) Rita Maria Concetta Di Martino et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Mitocentric View of Alzheimer’s Disease

(2016) Hao Hu et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

(2016) A.M. Bertholet et al.   NEUROBIOLOGY OF DISEASE

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease

(2016) Kalpita Banerjee et al.   NEUROCHEMISTRY INTERNATIONAL

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

(2016) Omolola R. Oyenihi et al.   Journal of Diabetes Research

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

(2015) Antonio Currais et al.   Aging-US

The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis

(2015) Huawei Cheng et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Long-Term Vitamin E-Deficient Mice Exhibit Cognitive Dysfunction via Elevation of Brain Oxidation

(2015) Koji FUKUI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death

(2015) Natascia Guida et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Efficacy ofGinkgo bilobaextract EGb 761®in dementia with behavioural and psychological symptoms: A systematic review

(2015) Armin von Gunten et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases

(2015) Isha Solanki et al.   Advances in Nutrition

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial genome maintenance in health and disease

(2014) William C. Copeland et al.   DNA REPAIR

Mechanisms of action of brain insulin against neurodegenerative diseases

(2014) Mahesh Ramalingam et al.   JOURNAL OF NEURAL TRANSMISSION

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model

(2014) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Insulin protects against Aβ-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption

(2014) Rasoul Ghasemi et al.   NEUROPHARMACOLOGY

Targeting the Prodromal Stage of Alzheimer’s Disease: Bioenergetic and Mitochondrial Opportunities

(2014) Charles C. Caldwell et al.   Neurotherapeutics

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

(2013) John W. Steele et al.   Autophagy

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

(2013) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

(2013) P R Bharadwaj et al.   Translational Psychiatry

Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease

(2012) Gunter P. Eckert et al.   MOLECULAR NEUROBIOLOGY

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease

(2011) Qi Chen et al.   PLoS One

The Puzzling Rise and Fall of a Dark-Horse Alzheimer's Drug

(2010) G. Miller   SCIENCE

Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection

(2009) Merce Pallas et al.   CURRENT NEUROVASCULAR RESEARCH

Diffusion tensor imaging in mild cognitive impairment and Alzheimerʼs disease: a review

(2009) Terence C Chua et al.   CURRENT OPINION IN NEUROLOGY

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

(2009) Tomohiko Sato et al.   NEUROBIOLOGY OF AGING

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI

(2007) Clifford R. Jack et al.   NEUROBIOLOGY OF AGING