An Epigenetic Role of Mitochondria in Cancer

Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias

(2022) Yan Yi et al.   Journal of Hematology & Oncology

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

(2022) Sylvain Delaunay et al.   NATURE

Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers

(2022) Kuo Chen et al.   Frontiers in Oncology

Oxygen regulation of TET enzymes

(2021) Rugile Matuleviciute et al.   FEBS Journal

Proteogenomic and metabolomic characterization of human glioblastoma

(2021) Liang-Bo Wang et al.   CANCER CELL

Urinary malate dehydrogenase 2 is a new biomarker for early detection of non‐small cell lung cancer

(2021) Yu‐Chen Ma et al.   CANCER SCIENCE

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

(2021) Ram Prosad Chakrabarty et al.   Cell Stem Cell

Mitochondria ensure immune surveillance by retro-communication with the nucleus

(2021) Manuel Rigon et al.   Cell Metabolism

Mitochondrial Sirtuins in Stem cells and Cancer

(2021) Amit Jaiswal et al.   FEBS Journal

Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

(2021) Fengying Wu et al.   Nature Communications

5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease

(2021) Janise N. Kuehner et al.   Cell Reports

IDH Inhibitors in AML—Promise and Pitfalls

(2021) Hannah McMurry et al.   Current Hematologic Malignancy Reports

560TiP A phase I/IIa study to evaluate the safety and efficacy of CCS1477, a first in clinic inhibitor of p300/CBP, as monotherapy in patients with selected molecular alterations

(2021) S. Crabb et al.   ANNALS OF ONCOLOGY

NAD + homeostasis in human health and disease

(2021) Rubén Zapata‐Pérez et al.   EMBO Molecular Medicine

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

(2021) Hongtu Cui et al.   EUROPEAN HEART JOURNAL

Histone H3K4me1 and H3K27ac play roles in nucleosome eviction and eRNA transcription, respectively, at enhancers

(2021) Yujin Kang et al.   FASEB JOURNAL

DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer

(2021) Qian Wang et al.   JOURNAL OF HEPATOLOGY

Nanotherapeutic approaches to target mitochondria in cancer

(2021) Shalini Mani et al.   LIFE SCIENCES

Epigenetic regulation of energy metabolism in obesity

(2021) Wei Gao et al.   Journal of Molecular Cell Biology

Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord

(2021) Sudheer K. Tungtur et al.   Scientific Reports

Metabolic reprogramming and epigenetic modifications on the path to cancer

(2021) Linchong Sun et al.   Protein & Cell

Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects

(2021) An-Na Chen et al.   Frontiers in Immunology

Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective

(2021) Sutong Xu et al.   Frontiers in Cell and Developmental Biology

Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies

(2021) Francis Kayamba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Post-translational modifications on mitochondrial metabolic enzymes in cancer

(2021) Yunhua Peng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria govern histone acetylation in colorectal cancer

(2021) Kenji Ohshima et al.   JOURNAL OF PATHOLOGY

Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs

(2021) Eva Schöller et al.   MOLECULAR CELL

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues

(2021) Iacopo Bicci et al.   NUCLEIC ACIDS RESEARCH

RNA methylation and cancer treatment

(2021) Baochen Yang et al.   PHARMACOLOGICAL RESEARCH

Histone lactylation: epigenetic mark of glycolytic switch

(2021) Xiaofeng Dai et al.   TRENDS IN GENETICS

Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy

(2021) Yu Mao et al.   Cell Death & Disease

Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

(2021) Ienglam Lei et al.   eLife

Advances in Genetics and Epigenetic Alterations in Alzheimer’s Disease: A Notion for Therapeutic Treatment

(2021) Rubén Rabaneda-Bueno et al.   Genes

Role and Function of O-GlcNAcylation in Cancer

(2021) Jii Bum Lee et al.   Cancers

The DNA methylation landscape in cancer

(2020) Ksenia Skvortsova et al.   Essays in Biochemistry

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

Quantum scale organic semiconductors for SERS detection of DNA methylation and gene expression

(2020) Swarna Ganesh et al.   Nature Communications

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

(2020) Sue Han et al.   BRITISH JOURNAL OF CANCER

Epigenetic dynamics in cancer stem cell dormancy

(2020) Alejandra I. Ferrer et al.   CANCER AND METASTASIS REVIEWS

Epigenetics of T cell fate decision

(2020) Luigia Pace et al.   CURRENT OPINION IN IMMUNOLOGY

Mitochondrial lactate metabolism: history and implications for exercise and disease

(2020) Brian Glancy et al.   JOURNAL OF PHYSIOLOGY-LONDON

IDH1-dependent α-KG regulates brown fat differentiation and function by modulating histone methylation

(2020) Hyun Sup Kang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B

(2020) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

(2020) Bernd Schöpf et al.   Nature Communications

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

(2020) Luodan Yang et al.   Translational Neurodegeneration

Targeting O-GlcNAcylation to develop novel therapeutics

(2020) Yi Zhu et al.   MOLECULAR ASPECTS OF MEDICINE

Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

(2020) Lia Walcher et al.   Frontiers in Immunology

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

N 6 ‐methyladenosine (m 6 A) RNA modification in human cancer

(2020) Fu‐Chun Huo et al.   CELL PROLIFERATION

S‐adenosylmethionine: A metabolite critical to the regulation of autophagy

(2020) Yang Ouyang et al.   CELL PROLIFERATION

Mitochondrial-induced epigenetic modifications: from biology to clinical translation

(2020) Jahnavi Sharma et al.   CURRENT PHARMACEUTICAL DESIGN

Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease

(2020) Ying Zhang et al.   FASEB JOURNAL

In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance

(2020) Chi Chun Wong et al.   GASTROENTEROLOGY

Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)

(2020) Toufike Kanouni et al.   JOURNAL OF MEDICINAL CHEMISTRY

The evolving metabolic landscape of chromatin biology and epigenetics

(2020) Ziwei Dai et al.   NATURE REVIEWS GENETICS

Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers

(2020) Kuo Chen et al.   SEMINARS IN CANCER BIOLOGY

Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases

(2020) Sanjeethan C. Baksh et al.   TRENDS IN CELL BIOLOGY

Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells

(2020) Shiqi She et al.   Cell Death & Disease

Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity

(2020) Li-Wa Shao et al.   Nature Communications

The function and regulation of TET2 in innate immunity and inflammation

(2020) Boyi Cong et al.   Protein & Cell

Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1

(2020) Jingqian Guan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondria as a Novel Target for Cancer Chemoprevention: Emergence of Mitochondrial Targeting Agents

(2020) Mofei Huang et al.   Cancer Prevention Research

Targeting p300/CBP attenuates hepatocellular carcinoma progression through epigenetic regulation of metabolism

(2020) Ling-Yan Cai et al.   CANCER RESEARCH

Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis

(2020) Guang Yang et al.   EMBO REPORTS

Current development of CBP/p300 inhibitors in the last decade

(2020) Zhang-Xu He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual targeting of G9a and DNMT1 for the treatment of experimental cholangiocarcinoma

(2020) Leticia Colyn et al.   HEPATOLOGY

Revisiting the Warburg effect: historical dogma versus current understanding

(2020) Peter Vaupel et al.   JOURNAL OF PHYSIOLOGY-LONDON

TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

(2020) Ricardo A. Irizarry-Caro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

(2020) Tie-Gang Meng et al.   Nature Communications

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

The Roles of Mitochondrial SIRT4 in Cellular Metabolism

(2019) Zheying Min et al.   Frontiers in Endocrinology

DNA Methylation Reprogramming during Mammalian Development

(2019) Yang Zeng et al.   Genes

Mito-Nuclear Communication by Mitochondrial Metabolites and Its Regulation by B-Vitamins

(2019) Joëlle J. E. Janssen et al.   Frontiers in Physiology

Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates

(2019) Xiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress

(2019) Mengli Zhang et al.   PLoS One

Succinylation Links Metabolism to Protein Functions

(2019) Yun Yang et al.   NEUROCHEMICAL RESEARCH

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis

(2019) Yuanzhen Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

α-Ketoglutarate inhibits autophagy

(2019) Elisa Elena Baracco et al.   Aging-US

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart from Failure

(2019) Mariya Kronlage et al.   CIRCULATION

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma

(2019) Hanneke Vlaming et al.   EMBO JOURNAL

Epidrugs: targeting epigenetic marks in cancer treatment

(2019) Cristiana Libardi Miranda Furtado et al.   Epigenetics

Connections between metabolism and epigenetics in cancers

(2019) Chitra Thakur et al.   SEMINARS IN CANCER BIOLOGY

A Pan-cancer Transcriptome Analysis Reveals Pervasive Regulation through Alternative Promoters

(2019) Deniz Demircioğlu et al.   CELL

Epigenetics: The master control of endothelial cell fate in cancer

(2019) Ayappa V.Subramaniam et al.   LIFE SCIENCES

α-Ketoglutarate links p53 to cell fate during tumour suppression

(2019) John P. Morris et al.   NATURE

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication

(2019) Yang Liu et al.   SCIENCE

An Open-Label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477, a First in Clinic Inhibitor of the p300/CPB Bromodomains, As Monotherapy in Patients with Advanced Haematological Malignancies

(2019) Tomasz Knurowski et al.   BLOOD

Alcohol metabolism contributes to brain histone acetylation

(2019) P. Mews et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis

(2019) Nisha Nair et al.   RHEUMATOLOGY

The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1

(2019) Berhane Ghebrehiwet et al.   SEMINARS IN IMMUNOLOGY

Mitochondria – A Powerful Therapeutic Target

(2019) Claudia Willmes   TRENDS IN MOLECULAR MEDICINE

Targeting citrate as a novel therapeutic strategy in cancer treatment

(2019) Lan Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting Succinate Metabolism in Ischemia/Reperfusion Injury

(2019) Duvaraka Kula-Alwar et al.   CIRCULATION

Histone Lactylation: A New Role for Glucose Metabolism

(2019) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Where Hematopoietic Stem Cells Live: The Bone Marrow Niche

(2018) Krzysztof Szade et al.   ANTIOXIDANTS & REDOX SIGNALING

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

(2018) Eytan M. Stein et al.   BLOOD

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

(2018) Matthew S. Waitkus et al.   CANCER CELL

Dimethyl fumarate: targeting glycolysis to treat MS

(2018) Stefano Angiari et al.   CELL RESEARCH

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

Acetyl-CoA-directed gene transcription in cancer cells

(2018) Inmaculada Martínez-Reyes et al.   GENES & DEVELOPMENT

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling

(2018) Joyce V. Lee et al.   GENES & DEVELOPMENT

DNA Damage, Mutagenesis and Cancer

(2018) Ashis Basu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

(2018) Maria Cristina Manara et al.   MOLECULAR CANCER THERAPEUTICS

The landscape of genomic alterations across childhood cancers

(2018) Susanne N. Gröbner et al.   NATURE

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Malate valves: Old shuttles with new perspectives

(2018) Jennifer Selinski et al.   PLANT BIOLOGY

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

(2018) Janeta Popovici-Muller et al.   ACS Medicinal Chemistry Letters

SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A

(2018) Wenguang Liu et al.   Oncology Letters

Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine

(2018) Mao-Hua Cai et al.   Scientific Reports

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

(2018) Shigeru Matsuda et al.   Scientific Reports

The Antioxidative Function of Alpha-Ketoglutarate and Its Applications

(2018) Shaojuan Liu et al.   Biomed Research International

DNA methylation reprogramming of functional elements during mammalian embryonic development

(2018) Congru Li et al.   Cell Discovery

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

(2018) Amila Suraweera et al.   Frontiers in Oncology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

The role of α-ketoglutarate-dependent proteins in pluripotency acquisition and maintenance

(2018) Khoa Anh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

(2018) Xiaotu Ma et al.   NATURE

Mitochondrial translation requires folate-dependent tRNA methylation

(2018) Raphael J. Morscher et al.   NATURE

Genetic and epigenetic determinants of AML pathogenesis

(2018) Sheng F. Cai et al.   SEMINARS IN HEMATOLOGY

Epigenetics and Metabolism in Health and Disease

(2018) Evangelia Tzika et al.   Frontiers in Genetics

Beyond histone acetylation—writing and erasing histone acylations

(2018) Shuai Zhao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DNA Methyltransferase Inhibitors and Their Therapeutic Potential

(2018) Zehao Zhou et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Current trends in protein acetylation analysis

(2018) Issa Diallo et al.   Expert Review of Proteomics

Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell

(2018) Yibing Si et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer

(2018) Liang Shi et al.   Molecular Oncology

The many lives of KATs — detectors, integrators and modulators of the cellular environment

(2018) Bilal N. Sheikh et al.   NATURE REVIEWS GENETICS

DNA hydroxymethylation changes in response to spinal cord damage in a multiple sclerosis mouse model

(2018) Yan Tang et al.   Epigenomics

Mitochondria-Targeted Drugs

(2018) Roman A. Zinovkin et al.   Current Molecular Pharmacology

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

The effect of oxaloacetic acid on tyrosinase activity and structure: Integration of inhibition kinetics with docking simulation

(2017) Lin Gou et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence

(2017) Hyun-Jung Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain

(2017) Yuxun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Procaine is a specific DNA methylation inhibitor with anti-tumor effect for human gastric cancer

(2017) Yong-Chao Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Epigenetics in cancer stem cells

(2017) Tan Boon Toh et al.   Molecular Cancer

Intra-tumor heterogeneity from a cancer stem cell perspective

(2017) Pramudita R. Prasetyanti et al.   Molecular Cancer

Mechanisms of Pinometostat (EPZ-5676) Treatment–Emergent Resistance in MLL -Rearranged Leukemia

(2017) Carly T. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation

(2017) Laure Ferry et al.   MOLECULAR CELL

Histone methylation and the DNA damage response

(2017) Fade Gong et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

(2017) Yugang Wang et al.   NATURE

Intragenic DNA methylation prevents spurious transcription initiation

(2017) Francesco Neri et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

Maternal H3K27me3 controls DNA methylation-independent imprinting

(2017) Azusa Inoue et al.   NATURE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

(2017) Frank Lyko   NATURE REVIEWS GENETICS

A novel requirement for DROSHA in maintenance of mammalian CG methylation

(2017) Athanasia Stathopoulou et al.   NUCLEIC ACIDS RESEARCH

Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect

(2017) Smriti Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA modification landscape in human disease

(2017) Nicky Jonkhout et al.   RNA

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

(2017) Olli Matilainen et al.   TRENDS IN CELL BIOLOGY

Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma

(2017) Aditi Qamra et al.   Cancer Discovery

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation

(2017) Suman Das et al.   Cell Reports

Evidence Suggesting Absence of Mitochondrial DNA Methylation

(2017) Mie Mechta et al.   Frontiers in Genetics

Down-regulation of SIRT3 promotes ovarian carcinoma metastasis

(2016) Xue-cai Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuins, Cell Senescence, and Vascular Aging

(2016) Yujiro Kida et al.   CANADIAN JOURNAL OF CARDIOLOGY

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development

(2016) Rui Lu et al.   CANCER CELL

Intratumoral Heterogeneity of the Epigenome

(2016) Tali Mazor et al.   CANCER CELL

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State

(2016) Wen Gu et al.   Cell Stem Cell

O-GlcNAcylation of histone deacetylases 1 in hepatocellular carcinoma promotes cancer progression

(2016) Guizhou Zhu et al.   GLYCOBIOLOGY

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

(2016) Yasushi Taniguchi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

(2016) Yongcheng Song et al.   Journal of Hematology & Oncology

Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8

(2016) Daisuke Kurotaki et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Lactate metabolism is associated with mammalian mitochondria

(2016) Ying-Jr Chen et al.   Nature Chemical Biology

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management

(2016) Bernard Thienpont et al.   Epigenomics

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells

(2016) Luigi Ippolito et al.   Oncotarget

L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats

(2016) Indra N. Waack et al.   Biomed Research International

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer

(2015) Ke Chen et al.   CELL RESEARCH

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

ROS-Mediated DNA Methylation Pattern Alterations in Carcinogenesis

(2015) Qihan Wu et al.   CURRENT DRUG TARGETS

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

(2015) S. Meidhof et al.   EMBO Molecular Medicine

Histone demethylases in chromatin biology and beyond

(2015) E. Dimitrova et al.   EMBO REPORTS

A role for KMT1c in monocyte to dendritic cell differentiation

(2015) Rutger J. Wierda et al.   HUMAN IMMUNOLOGY

Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia

(2015) Franck Morschhauser et al.   INVESTIGATIONAL NEW DRUGS

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

(2015) Tuomas Laukka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic linkage of aging, cancer and nutrition

(2015) M. Daniel et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

OH, the Places You’ll Go! Hydroxylation, Gene Expression, and Cancer

(2015) Athanasios Ploumakis et al.   MOLECULAR CELL

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

(2015) Peter Bai   MOLECULAR CELL

Structural insight into substrate preference for TET-mediated oxidation

(2015) Lulu Hu et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

(2015) Bartlomiej Waclaw et al.   NATURE

Protein acetylation in metabolism — metabolites and cofactors

(2015) Keir J. Menzies et al.   Nature Reviews Endocrinology

Differential regulation of genomic imprinting by TET proteins in embryonic stem cells

(2015) Lizhi Liu et al.   Stem Cell Research

Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression

(2015) Yuan Shen et al.   TRENDS IN PLANT SCIENCE

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

(2015) Rajneesh Pathania et al.   Nature Communications

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors

(2015) Attje S. Hoekstra et al.   Oncotarget

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress

(2015) Benjamin Delatte et al.   Scientific Reports

Protein acetylation as a means to regulate protein function in tune with metabolic state

(2014) Lei Shi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells

(2014) Sahra Borges et al.   BREAST CANCER RESEARCH AND TREATMENT

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Anti-Tumoral Effect of the Non-Nucleoside DNMT Inhibitor RG108 in Human Prostate Cancer Cells

(2014) Ines Graca et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

5-Hydroxymethylcytosine and disease

(2014) Jingyu Wang et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression

(2014) Hong Wen et al.   NATURE

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

(2014) Daniel Kraus et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK regulates histone H2B O-GlcNAcylation

(2014) Qiuran Xu et al.   NUCLEIC ACIDS RESEARCH

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

(2014) Prithviraj Bose et al.   PHARMACOLOGY & THERAPEUTICS

Citrate Synthase Expression Affects Tumor Phenotype and Drug Resistance in Human Ovarian Carcinoma

(2014) Lilan Chen et al.   PLoS One

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Brief Reports: A Distinct DNA Methylation Signature Defines Breast Cancer Stem Cells and Predicts Cancer Outcome

(2014) Rita El Helou et al.   STEM CELLS

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

(2014) Twan van den Beucken et al.   Nature Communications

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

LSD1 promotes oxidative metabolism of white adipose tissue

(2014) Delphine Duteil et al.   Nature Communications

The Sirtuin 3 Expression Profile Is Associated with Pathological and Clinical Outcomes in Colon Cancer Patients

(2014) Chunyuan Liu et al.   Biomed Research International

New Nucleophilic Mechanisms of Ros-Dependent Epigenetic Modifications: Comparison of Aging and Cancer

(2014) Igor Afanas’ev   Aging and Disease

O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins

(2014) Vanessa Dehennaut et al.   Frontiers in Endocrinology

SIRT6, a protein with many faces

(2013) Asaf A. Gertler et al.   BIOGERONTOLOGY

Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line

(2013) Patricia García-Domínguez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

(2013) A. Chaturvedi et al.   BLOOD

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation

(2013) Lulu Hu et al.   CELL

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction

(2013) S. Martin et al.   CURRENT MEDICINAL CHEMISTRY

The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing

(2013) S. Imai et al.   DIABETES OBESITY & METABOLISM

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

(2013) Rachel Deplus et al.   EMBO JOURNAL

Sunitinib malate in the treatment of urothelial cancer

(2013) Francesc Pons et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

TET3-OGT interaction increases the stability and the presence of OGT in chromatin

(2013) Ryo Ito et al.   GENES TO CELLS

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regionally Specific and Genome-Wide Analyses Conclusively Demonstrate the Absence of CpG Methylation in Human Mitochondrial DNA

(2013) E. E. Hong et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

The nexus of chromatin regulation and intermediary metabolism

(2013) Philipp Gut et al.   NATURE

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

(2013) Olesya A Ulanovskaya et al.   Nature Chemical Biology

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

(2013) Christoph Plass et al.   NATURE REVIEWS GENETICS

DNA methylation dynamics in health and disease

(2013) Yehudit Bergman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lactate dehydrogenase A silencing in IDH mutant gliomas

(2013) Charles Chesnelong et al.   NEURO-ONCOLOGY

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

(2013) S. Rokudai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Role of DNA Methylation in the Pathogenesis and Treatment of Myelodysplastic Syndromes

(2013) Hina Khan et al.   SEMINARS IN HEMATOLOGY

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

Nuclear Exclusion of TET1 Is Associated with Loss of 5-Hydroxymethylcytosine in IDH1 Wild-Type Gliomas

(2012) Tim Müller et al.   AMERICAN JOURNAL OF PATHOLOGY

Histone/protein deacetylases and T-cell immune responses

(2012) T. Akimova et al.   BLOOD

MG98, a Second-Generation DNMT1 Inhibitor, in the Treatment of Advanced Renal Cell Carcinoma

(2012) Robert J. Amato et al.   CANCER INVESTIGATION

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

(2012) Romain Barrès et al.   Cell Metabolism

Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives

(2012) Kristopher L. Nazor et al.   Cell Stem Cell

Mitochondrial regulation of epigenetics and its role in human diseases

(2012) Sheroy Minocherhomji et al.   Epigenetics

Basic concepts of epigenetics

(2012) Elizabeth A. Mazzio et al.   Epigenetics

Targeting drugs to mitochondria

(2012) Anne Heller et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

The mitochondrial oxoglutarate carrier: from identification to mechanism

(2012) Magnus Monné et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

β-N-Acetylglucosamine (O-GlcNAc) Is a Novel Regulator of Mitosis-specific Phosphorylations on Histone H3

(2012) Jerry J. Fong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers

(2012) Jiyeon Yun et al.   LABORATORY INVESTIGATION

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Histone Acetylation Regulates Intracellular pH

(2012) Matthew A. McBrian et al.   MOLECULAR CELL

Epigenetic alterations involved in cancer stem cell reprogramming

(2012) Purificación Muñoz et al.   Molecular Oncology

TET2 promotes histone O-GlcNAcylation during gene transcription

(2012) Qiang Chen et al.   NATURE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms and potential functions of histone demethylases

(2012) Susanne Marije Kooistra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A two-way street: reciprocal regulation of metabolism and signalling

(2012) Kathryn E. Wellen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability

(2012) Mikako Yagi et al.   NUCLEIC ACIDS RESEARCH

Exogenous expression of UHRF1 promotes proliferation and metastasis of breast cancer cells

(2012) Xin-Li Li   ONCOLOGY REPORTS

Targeted proteomics for quantification of histone acetylation in Alzheimer's disease

(2012) Kangling Zhang et al.   PROTEOMICS

Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3

(2012) Kyoung Ah Kang et al.   TUMOR BIOLOGY

The Role of Bromodomain Proteins in Regulating Gene Expression

(2012) Gabrielle A. Josling et al.   Genes

Artefacts in cell culture: α-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media

(2011) Lee Hua Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

Primate CpG Islands Are Maintained by Heterogeneous Evolutionary Regimes Involving Minimal Selection

(2011) Netta Mendelson Cohen et al.   CELL

DNA Demethylation Dynamics

(2011) Nidhi Bhutani et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

(2011) Michael Van Meter et al.   CELL CYCLE

Mitochondrial Drug Targets in Cell Death and Cancer

(2011) Gustavo Ferrin et al.   CURRENT PHARMACEUTICAL DESIGN

Advances in the computational development of DNA methyltransferase inhibitors

(2011) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

Reactive oxygen species downregulate catalase expression via methylation of a CpG Island in the Oct-1 promoter

(2011) Xiaoyuan Quan et al.   FEBS LETTERS

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Modification of Histones by Sugar β-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated

(2011) Suisheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment

(2011) Emily Hodges et al.   MOLECULAR CELL

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

(2011) Dominique Ziech et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

GlcNAcylation of histone H2B facilitates its monoubiquitination

(2011) Ryoji Fujiki et al.   NATURE

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

(2011) Gabriella Ficz et al.   NATURE

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

(2011) Benjamin P Berman et al.   NATURE GENETICS

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

(2011) D. R. Borger et al.   ONCOLOGIST

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

DNA methylation in stem cell renewal and multipotency

(2011) María Berdasco et al.   Stem Cell Research & Therapy

Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis

(2010) Sang-Hoon Shin et al.   AMINO ACIDS

Identification of NAD interacting residues in proteins

(2010) Hifzur R Ansari et al.   BMC BIOINFORMATICS

A novel role for mitochondria in regulating epigenetic modifications in the nucleus

(2010) Dominic Smiraglia et al.   CANCER BIOLOGY & THERAPY

Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

(2010) A. Sottoriva et al.   CANCER RESEARCH

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells

(2010) R. David Hawkins et al.   Cell Stem Cell

Epigenetics Gets Sweeter: O-GlcNAc Joins the “Histone Code”

(2010) John A. Hanover   CHEMISTRY & BIOLOGY

Structural insights into histone lysine demethylation

(2010) Haifeng Hou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry

(2010) María Berdasco et al.   DEVELOPMENTAL CELL

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases

(2010) David C. Bedford et al.   Epigenetics

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

BlockingO-Linked GlcNAc Cycling inDrosophilaInsulin-producing Cells Perturbs Glucose-Insulin Homeostasis

(2010) Osamu Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication

(2010) Peter Paschka et al.   JOURNAL OF CLINICAL ONCOLOGY

Recruitment of Polycomb Complexes: a Role for SCM: FIG. 1.

(2010) Judith A. Kassis et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation

(2010) V. Fogal et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Chromatin structure and the inheritance of epigenetic information

(2010) Raphaël Margueron et al.   NATURE REVIEWS GENETICS

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

(2010) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

 -N-acetylglucosamine (O-GlcNAc) is part of the histone code

(2010) K. Sakabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis

(2009) Motoko Unoki et al.   BIOCHEMICAL PHARMACOLOGY

The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine

(2009) John A. Hanover et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors

(2009) Takayoshi Suzuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density

(2009) Romain Barrès et al.   Cell Metabolism

Molecular Modeling and Molecular Dynamics Studies of Hydralazine with Human DNA Methyltransferase 1

(2009) Narender Singh et al.   ChemMedChem

Epigenetics, stem cells and epithelial cell fate

(2009) Audrey Vincent et al.   DIFFERENTIATION

Imprinting evolution and human health

(2009) Radhika Das et al.   MAMMALIAN GENOME

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Protein methyltransferases as a target class for drug discovery

(2009) Robert A. Copeland et al.   NATURE REVIEWS DRUG DISCOVERY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)

(2009) D. A. R. Sinclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation

(2008) J. Zhang et al.   BLOOD

Evolution of decitabine development

(2008) Elias Jabbour et al.   CANCER

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression

(2008) Yinhong Song et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

(2008) Akiko Murayama et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Promoter CpG Methylation Contributes to ES Cell Gene Regulation in Parallel with Oct4/Nanog, PcG Complex, and Histone H3 K4/K27 Trimethylation

(2008) Shaun D. Fouse et al.   Cell Stem Cell

Chromatin remodeling during mouse and human embryonic stem cell differentiation

(2008) Jonathan L. Golob et al.   DEVELOPMENTAL DYNAMICS

Mitochondria andl-lactate metabolism

(2008) Salvatore Passarella et al.   FEBS LETTERS

Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter

(2008) Seung-Oe Lim et al.   GASTROENTEROLOGY

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

(2008) Liqin Zhu et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Genome-scale DNA methylation maps of pluripotent and differentiated cells

(2008) Alexander Meissner et al.   NATURE

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Introduction: diet, epigenetic events and cancer prevention

(2008) Sharon A Ross et al.   NUTRITION REVIEWS

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Stemming Cancer: Functional Genomics of Cancer Stem Cells in Solid Tumors

(2008) C. R. A. Regenbrecht et al.   Stem Cell Reviews and Reports

The functional consequences of alternative promoter use in mammalian genomes

(2008) Ramana V. Davuluri et al.   TRENDS IN GENETICS