Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 179, Issue -, Pages 11-23Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2021.12.264
Keywords
TCA cycle; OXPHOS; Post-translational modification; Metabolism; Mitochondrial biogenesis; Mitophagy
Funding
- National Natural Science Foundation of China [81802787, 31700684, 31870848, 31770917, 31570777, 91649106, 32171102]
- National Basic Research Program of China [973 Program] [2015CB856302, 2015CB553602]
- China Postdoctoral Science Foundation [2018M643673]
- National Key Research and Development Projects of China [2019YFD1002400]
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Mitochondria play a crucial role in the initiation and development of tumor cells, with metabolic proteins serving as key mediators in tumorigenesis. Understanding mitochondria-related post-translational modifications is important for the future of cancer treatment.
Mitochondrion is the powerhouse of the cell. The research of nearly a century has expanded our understanding of mitochondrion, far beyond the view that mitochondrion is an important energy generator of cells. During the initiation, growth and survival of tumor cells, significant mitochondrial metabolic changes have taken place in the important enzymes of respiratory chain and tricarboxylic acid cycle, mitochondrial biogenesis and dynamics, oxidative stress regulation and molecular signaling. Therefore, mitochondrial metabolic proteins are the key mediators of tumorigenesis. Post-translational modification is the molecular switch that regulates protein function. Understanding how these mitochondria-related post-translational modification function during tumorigenesis will bring new ideas for the next generation of cancer treatment.
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