Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume -, Issue -, Pages 201820574
Publisher
Proceedings of the National Academy of Sciences
Online
2019-02-05
DOI
10.1073/pnas.1820574116
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study
- (2018) Lina Keller et al. JOURNAL OF ALZHEIMERS DISEASE
- Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
- (2018) Jiangbo Wei et al. MOLECULAR CELL
- m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
- (2017) Hua-Bing Li et al. NATURE
- RNA m6A methylation regulates the ultraviolet-induced DNA damage response
- (2017) Yang Xiang et al. NATURE
- m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
- (2016) Irmgard U. Haussmann et al. NATURE
- Reversible methylation of m6Am in the 5′ cap controls mRNA stability
- (2016) Jan Mauer et al. NATURE
- m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome
- (2016) Benoit Molinie et al. NATURE METHODS
- Dynamic m6A mRNA methylation directs translational control of heat shock response
- (2015) Jun Zhou et al. NATURE
- Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
- (2015) Bastian Linder et al. NATURE METHODS
- m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
- (2015) Shay Geula et al. SCIENCE
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- (2014) Xu Zhao et al. CELL RESEARCH
- Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
- (2014) Chao Xu et al. Nature Chemical Biology
- RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
- (2013) Jean-Michel Fustin et al. CELL
- The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
- (2013) Martin E Hess et al. NATURE NEUROSCIENCE
- FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA
- (2013) Ye Fu et al. Nature Communications
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- Crystal structure of the FTO protein reveals basis for its substrate specificity
- (2010) Zhifu Han et al. NATURE
- Overexpression of Fto leads to increased food intake and results in obesity
- (2010) Chris Church et al. NATURE GENETICS
- Structural and Mutational Analysis of Escherichia coli AlkB Provides Insight into Substrate Specificity and DNA Damage Searching
- (2010) Paul J. Holland et al. PLoS One
- The genetics of obesity: FTO leads the way
- (2010) Katherine A. Fawcett et al. TRENDS IN GENETICS
- Inactivation of the Fto gene protects from obesity
- (2009) Julia Fischer et al. NATURE
- Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
- (2008) Guifang Jia et al. FEBS LETTERS
- Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
- (2008) Cai-Guang Yang et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation