Article
Medicine, Research & Experimental
Rui Kong, Nan Wang, Wei Han, Wen Bao, Jie Lu
Summary: Through bioinformatics analysis and in vitro experiments, fenofibrate was found to regulate cell cycle, promote apoptosis, suppress cell proliferation, and inhibit epithelial mesenchymal transition by activating PPARA, potentially serving as a therapeutic agent for colon cancer patients.
Article
Biochemistry & Molecular Biology
Waseem Ashraf, Tanveer Ahmad, Naif A. R. Almalki, Mounira Krifa, Liliyana Zaayter, Antonio Pizzi, Christian D. Muller, Ali Hamiche, Yves Mely, Christian Bronner, Marc Mousli
Summary: Maritime pine tannin extract (MPTE) has shown potential in anticancer therapy by inhibiting cancer cell proliferation and inducing apoptosis, while sparing non-cancerous cells. It plays a pro-oxidant role in cancer cells and affects the expression of tumor suppressor genes and protooncogenic proteins, indicating promising prospects for cancer treatment.
Article
Biochemistry & Molecular Biology
Qiting Zhang, Ziyan Wang, Xinyuan Chen, Haoxiang Qiu, Yifan Gu, Ning Wang, Tao Wang, Ze Wang, Huabin Ma, Yufen Zhao, Bin Zhang
Summary: The compound 8a acts as an HDAC1 inhibitor with anti-proliferative and pro-apoptotic activities against leukemia cells, mainly entering the nucleus and inducing cell apoptosis through the mitochondrial pathway. It also affects the expression of DNMT1, leading to inhibition of proliferation and promotion of apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yue Zhang, Hongdong Huang, Wenhu Liu, Sha Liu, Xue Yan Wang, Zong Li Diao, Ai Hua Zhang, Wang Guo, Xue Han, Xiaoqun Dong, Oleksandr Katilov
Summary: miR-21-5p regulates the role of endothelial progenitor cells-derived exosomes in sepsis-induced acute kidney injury through downregulation of RUNX1 expression. Upregulation of miR-21-5p improved renal function and reduced inflammation, while EPCs-exos showed similar effects in this process.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Inorganic & Nuclear
Salih Pasa, Omer Erdogan, Ozge Cevik
Summary: The procaine derivatives combined with palladium demonstrated significant cytotoxicity against human gastric cancer cells, inhibiting colony formation and wound healing, and inducing apoptosis. Furthermore, these complexes showed potential as new DNMT inhibitors for preventing cancer-induced DNA hypermethylation.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Oncology
Juanli Qiao, Yuan Tian, Xiaojing Cheng, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang, Lianhai Zhang, Jiafu Ji, Rui Xing, Dajun Deng
Summary: The study suggests that somatic copy number deletion of the CDKN2A gene may drive gastric cancer metastasis and could serve as a predictor for hematogenous metastasis of gastric cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dongxing Shao, Cihang Liu, Yingying Wang, Jing Lin, Xiaolei Cheng, Pei Han, Zhen Li, Dongdong Jian, Junwei Nie, Mingyang Jiang, Yuanzhi Wei, Junyue Xing, Zhiping Guo, Wengong Wang, Xia Yi, Hao Tang
Summary: This study reveals the interplay between DNA methylation by DNMT1 and mRNA methylation by NSun2 in regulating osteosarcoma cell apoptosis. DNMT1 induces promoter methylation of NSun2, resulting in its suppressed expression. Additionally, DNMT1 and NSun2 regulate the expression of anti-apoptotic genes AXL, NOTCH2, and YAP1 through DNA and mRNA methylation. The findings highlight the importance of DNA and RNA cytosine methylations in determining osteosarcoma resistance to apoptosis during chemotherapy.
Article
Biotechnology & Applied Microbiology
Xiangming Xu, Jiao Nie, Lin Lu, Chao Du, Fansheng Meng, Duannuo Song
Summary: This study demonstrates that LINC00337 facilitates tumorigenesis and angiogenesis in colorectal cancer by recruiting DNMT1 to inhibit the expression of CNN1.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiaofeng Zhou, Yingting He, Xiangchun Pan, Hongyan Quan, Bo He, Yongguang Li, Guofeng Bai, Nian Li, Zhe Zhang, Hao Zhang, Jiaqi Li, Xiaolong Yuan
Summary: DNA methylation and lncRNAs play important roles in follicular development. However, the mechanisms of lncRNAs mediated by DNA methylation in follicular development are still unclear. In this study, we found that inhibiting DNMT1 expression promotes granulosa cell apoptosis and inhibits follicular development. We identified a novel lncRNA called IFFD that is regulated by DNMT1 and inhibits follicular development by affecting granulosa cell proliferation, estrogen secretion, and apoptosis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Zhao-Hui Chen, Yi-Bo Chen, Hao-Ran Yue, Xue-Jie Zhou, Hai-Yan Ma, Xin Wang, Xu-Chen Cao, Yue Yu
Summary: This study identified PAX5 as the upstream regulator of miR-142-5p/3p and demonstrated that PAX5 functions as a tumor suppressor by positively regulating miR-142-5p/3p. The expression of PAX5 is regulated by DNMT1 and ZEB1-mediated methylation of its promoter region. Moreover, miR-142-5p/3p regulates the expression of DNMT1 and ZEB1 by binding to their 3'UTR region, respectively. In conclusion, PAX5-miR-142-DNMT1/ZEB1 forms a negative feedback loop to regulate the progression of breast cancer.
MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Yuting Tang, Fangling Hong, Siyang Ding, Jiashu Yang, Ming Zhang, Yunfei Ma, Que Zheng, Dawei Yang, Yucui Jin, Changyan Ma
Summary: In this study, it was found that the upregulation of long noncoding RNA (lncRNA) IGFBP7-OT and its maternal gene, IGFBP7, in osteoarthritic cartilage were positively correlated. Overexpression of IGFBP7-OT inhibited chondrocyte viability, promoted chondrocyte apoptosis, and reduced extracellular matrix components, while knockdown of IGFBP7-OT had the opposite effects. IGFBP7-OT overexpression promoted cartilage degeneration and aggravated the monosodium iodoacetate-induced osteoarthritis phenotype in vivo. Mechanistic research revealed that IGFBP7-OT promoted osteoarthritis progression by upregulating IGFBP7 expression through inhibiting methylation of the IGFBP7 promoter by suppressing the occupancy of DNMT1 and DNMT3a. The upregulation of IGFBP7-OT in osteoarthritis was partially controlled by METTL3-mediated N6-methyladenosine (m6A) modification.
Article
Biochemistry & Molecular Biology
S. Sun, Z. Wang, F. Yao, K. Sun, Z. Li, C. Li
Summary: The study found that microRNA-155 loaded by breast cancer cell-derived exosomes inhibits the generation of white adipose tissue and promotes the formation of brown adipose tissue, leading to cachexia. It was also discovered that this effect is associated with miR-155 targeting UBQLN1.
HUMAN MOLECULAR GENETICS
(2023)
Article
Biology
Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu, Huizhuo Xu
Summary: The study found that DNMT1-mediated PPAR alpha methylation promotes apoptosis and ROS levels in HRCPs, exacerbating retinal tissue damage in DR mice.
BIOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Romina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Ali Salaritabar, Mohammad Amin Javidi
Summary: The average survival of patients with glioblastoma is 12-15 months, making it crucial to find new treatment methods, especially for cases resistant to current therapies. This research investigates the antitumor effect of extremely low-frequency electromagnetic fields (ELF-EMF) on specific glioblastoma cell lines. The findings suggest that ELF-EMF induces apoptosis and regulates cell cycle progression, potentially offering a low-side effect cancer treatment option.
SCIENTIFIC REPORTS
(2023)
Review
Genetics & Heredity
Kommu Naga Mohan
Summary: DNMT1 is a key enzyme responsible for methylating the daughter strand in newly replicated DNA. Apart from its role in gene repression through methylation, recent data suggest that DNMT1 can also modulate gene expression independent of its catalytic activity and participate in various processes such as the cell cycle, DNA damage repair, and stem cell function.