NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

Current Chemical Biology Approaches to Interrogate Protein Methyltransferases

(2012) Minkui Luo   ACS Chemical Biology

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Epigenetic Regulation of Cell Adhesion and Communication by Enhancer of Zeste Homolog 2 in Human Endothelial Cells

(2012) Henryk Dreger et al.   HYPERTENSION

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

Structural Basis of Substrate Recognition in Human NicotinamideN-Methyltransferase

(2011) Yi Peng et al.   BIOCHEMISTRY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

Glycine-N Methyltransferase Expression in HepG2 Cells Is Involved in Methyl Group Homeostasis by Regulating Transmethylation Kinetics and DNA Methylation

(2011) Yi-Cheng Wang et al.   JOURNAL OF NUTRITION

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Characterization of Nicotinamidases: Steady State Kinetic Parameters, Classwide Inhibition by Nicotinaldehydes, and Catalytic Mechanism

(2010) Jarrod B. French et al.   BIOCHEMISTRY

SNAI2/Slug promotes growth and invasion in human gliomas

(2010) Hong Wei Yang et al.   BMC CANCER

Nicotinamide N -methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells

(2010) Sai-Wen Tang et al.   CARCINOGENESIS

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

(2010) Marta Varela-Rey et al.   HEPATOLOGY

PME-1 Protects Extracellular Signal-Regulated Kinase Pathway Activity from Protein Phosphatase 2A-Mediated Inactivation in Human Malignant Glioma

(2009) P. Puustinen et al.   CANCER RESEARCH

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis

(2009) Tobias Joyce et al.   CLINICAL & EXPERIMENTAL METASTASIS

Serum levels of nicotinamide N-methyltransferase in patients with lung cancer

(2009) Mikio Tomida et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis

(2009) Jongmin Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A combined experimental and theoretical study of the pH-dependent binding mode of NAD+by water-soluble molecular clips

(2009) Jolanta Polkowska et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Kinetic flux profiling for quantitation of cellular metabolic fluxes

(2008) Jie Yuan et al.   Nature Protocols

Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration

(2008) Y Wu et al.   ONCOGENE