TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

IDH2 inhibition in AML: Finally progress?

(2015) Eytan M. Stein   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

(2015) X. Guo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

(2015) Maria Peiris-Pagès et al.   Cell Metabolism

Structural insight into substrate preference for TET-mediated oxidation

(2015) Lulu Hu et al.   NATURE

TET1 is a tumor suppressor of hematopoietic malignancy

(2015) Luisa Cimmino et al.   NATURE IMMUNOLOGY

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer

(2015) Rebecca S. Heist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature

(2015) Els Wauters et al.   THORAX

TET proteins and the control of cytosine demethylation in cancer

(2015) Laurianne Scourzic et al.   Genome Medicine

5-Hydroxymethylcytosine is a predominantly stable DNA modification

(2014) Martin Bachman et al.   Nature Chemistry

Connections between TET proteins and aberrant DNA modification in cancer

(2014) Yun Huang et al.   TRENDS IN GENETICS

MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling

(2013) Su Jung Song et al.   CELL

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

(2012) Kim De Keersmaecker et al.   NATURE GENETICS

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

(2012) H Yang et al.   ONCOGENE

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations

(2011) Y.-H. Kim et al.   JOURNAL OF CLINICAL PATHOLOGY

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Decitabine Effect on Tumor Global DNA Methylation and Other Parameters in a Phase I Trial in Refractory Solid Tumors and Lymphomas

(2009) D. J. Stewart et al.   CLINICAL CANCER RESEARCH

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE