Journal
FEBS LETTERS
Volume 585, Issue 21, Pages 3436-3441Publisher
WILEY
DOI: 10.1016/j.febslet.2011.09.035
Keywords
Reactive oxygen species; Oct-1; Catalase; Methylation; Hepatocellular carcinoma
Funding
- Ministry of Health and Welfare, Republic of Korea [A101530]
- Overseas Koreans Foundation
- Korea Health Promotion Institute [A101530] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Reactive oxygen species (ROS) caused oxidative stress plays a key role in carcinogenesis. The POU domain transcription factor Oct-1 and catalase is closely associated with ROS. However, a correlation between these two key proteins has not been demonstrated before. In this report, we show that Oct-1 acts as an activator of catalase, by binding to the catalase promoter in hepatocellular carcinoma (HCC) cell lines. In addition, we suggest that Oct-1 is downregulated by ROS via CpG island methylation in its promoter. These findings contribute to a better understanding of the epigenetic changes induced by ROS in the process of carcinogenesis. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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