Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

(2013) Kyle D. Konze et al.   ACS Chemical Biology

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming

(2013) Neha Tiwari et al.   CANCER CELL

Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition

(2013) Michael Amatangelo et al.   CELL CYCLE

Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

(2013) Pallavi Chaturvedi et al.   JOURNAL OF CLINICAL INVESTIGATION

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia

(2012) Delphine Tamara Marie-Egyptienne et al.   CANCER LETTERS

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Functional Importance of Dicer Protein in the Adaptive Cellular Response to Hypoxia

(2012) J. J. David Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Polycomb genes and cancer: Time for clinical application?

(2011) Francesco Crea et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma

(2011) R Banerjee et al.   ONCOGENE

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells

(2010) Sonia A. Melo et al.   CANCER CELL

Lineage-Specific Transcriptional Regulation of DICER by MITF in Melanocytes

(2010) Carmit Levy et al.   CELL

A MicroRNA Targeting Dicer for Metastasis Control

(2010) Graziano Martello et al.   CELL

miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells

(2010) Yuk Cheung Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer

(2010) Tony Blick et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

BRCA1 tumours correlate with a HIF-1α phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression

(2009) M Yan et al.   BRITISH JOURNAL OF CANCER

Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype

(2009) G Grelier et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Dicer1 functions as a haploinsufficient tumor suppressor

(2009) M. S. Kumar et al.   GENES & DEVELOPMENT

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

(2009) M. Barradas et al.   GENES & DEVELOPMENT

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

(2009) K. Agger et al.   GENES & DEVELOPMENT

Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response

(2009) Twan van den Beucken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

(2009) Sonia A Melo et al.   NATURE GENETICS

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Cancer Stem Cells, Hypoxia and Metastasis

(2009) Richard P. Hill et al.   SEMINARS IN RADIATION ONCOLOGY

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

(2008) William M. Merritt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE

Hypoxia Enhances Tumor Stemness by Increasing the Invasive and Tumorigenic Side Population Fraction

(2008) Bikul Das et al.   STEM CELLS