Cancer stem cells: The challenges ahead

Molecular identification and targeting of colorectal cancer stem cells

(2015)   Oncotarget

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness

(2012) Enza Lonardo et al.   CELL CYCLE

The developing cancer stem-cell model: clinical challenges and opportunities

(2012) Louis Vermeulen et al.   LANCET ONCOLOGY

Stem cells: The right neighbour

(2012) Ilya A. Shestopalov et al.   NATURE

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer

(2012) Alejandra Bruna et al.   Nature Communications

Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

(2011) Suling Liu et al.   CANCER RESEARCH

ABCB5 Identifies a Therapy-Refractory Tumor Cell Population in Colorectal Cancer Patients

(2011) B. J. Wilson et al.   CANCER RESEARCH

Cancer Stem Cell Niche: The Place to Be

(2011) T. Borovski et al.   CANCER RESEARCH

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases

(2011) Sebastian M. Dieter et al.   Cell Stem Cell

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

(2011) Felipe de Sousa E Melo et al.   Cell Stem Cell

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

(2011) Enza Lonardo et al.   Cell Stem Cell

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice

(2011) Kuo–Shu Tsai et al.   GASTROENTEROLOGY

CD133 ProteinN-Glycosylation Processing Contributes to Cell Surface Recognition of the Primitive Cell Marker AC133 Epitope

(2011) Anthony B. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

(2011) Jan Paul Medema et al.   NATURE

The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation

(2011) J T Buijs et al.   ONCOGENE

CD44v6 Regulates Growth of Brain Tumor Stem Cells Partially through the AKT-Mediated Pathway

(2011) Mayumi Jijiwa et al.   PLoS One

Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity

(2010) A. Sottoriva et al.   CANCER RESEARCH

The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

(2010) K. Kemper et al.   CANCER RESEARCH

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Retinoid signaling regulates breast cancer stem cell differentiation

(2010) Christophe Ginestier et al.   CELL CYCLE

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

(2010) Roberta Pang et al.   Cell Stem Cell

Colon Cancer Stem Cells: Promise of Targeted Therapy

(2010) Matilde Todaro et al.   GASTROENTEROLOGY

Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

(2010) Ylenia Lombardo et al.   GASTROENTEROLOGY

Association of a Leukemic Stem Cell Gene Expression Signature With Clinical Outcomes in Acute Myeloid Leukemia

(2010) Andrew J. Gentles   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD133+ niches and single cells in glioblastoma have different phenotypes

(2010) Karina Christensen et al.   JOURNAL OF NEURO-ONCOLOGY

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Nuclear reprogramming to a pluripotent state by three approaches

(2010) Shinya Yamanaka et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers

(2010) Shan Deng et al.   PLoS One

The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

(2010) Irene Ma et al.   Stem Cell Reviews and Reports

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model

(2009) Kazuharu Kai et al.   CANCER SCIENCE

Tumor microvasculature supports proliferation and expansion of glioma-propagating cells

(2009) Tijana Borovski et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of CD44v6+/CD24− breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies

(2009) Eric L Snyder et al.   LABORATORY INVESTIGATION

Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors

(2008) J. M. Yi et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Cancer stem cells – old concepts, new insights

(2008) L Vermeulen et al.   CELL DEATH AND DIFFERENTIATION

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One

Prostate cancer stem cell therapy: hype or hope?

(2008) J R Masters et al.   PROSTATE CANCER AND PROSTATIC DISEASES

ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells

(2008) Julie Douville et al.   STEM CELLS AND DEVELOPMENT