The Role of Bromodomain Proteins in Regulating Gene Expression

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

(2012) Jonathan Seal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Bromodomain Protein Brd4 Associated with Acetylated Chromatin Is Important for Maintenance of Higher-order Chromatin Structure

(2012) Ranran Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

(2011) Alexander J. Ruthenburg et al.   CELL

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

(2011) Diana C Hargreaves et al.   CELL RESEARCH

A dual role of H4K16 acetylation in the establishment of yeast silent chromatin

(2011) Mariano Oppikofer et al.   EMBO JOURNAL

Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer

(2011) K Ted Thurn et al.   Future Oncology

Influence of Histone Tails and H4 Tail Acetylations on Nucleosome–Nucleosome Interactions

(2011) Ying Liu et al.   JOURNAL OF MOLECULAR BIOLOGY

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

(2011) S. Rahman et al.   MOLECULAR AND CELLULAR BIOLOGY

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

(2011) Martin Philpott et al.   Molecular BioSystems

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(2011) Jelena Vojinovic et al.   MOLECULAR MEDICINE

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms

(2011) Nilanjana Chatterjee et al.   NUCLEIC ACIDS RESEARCH

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2

(2010) Takashi Umehara et al.   FEBS LETTERS

Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2

(2010) J.-H. Kim et al.   GENES & DEVELOPMENT

Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain

(2010) Takashi Umehara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Dynamic changes in histone acetylation regulate origins of DNA replication

(2010) Ashwin Unnikrishnan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

(2010) A. Guidotti et al.   NEUROPHARMACOLOGY

The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association

(2010) Abdollah Allahverdi et al.   NUCLEIC ACIDS RESEARCH

Biochemical Profiling of Histone Binding Selectivity of the Yeast Bromodomain Family

(2010) Qiang Zhang et al.   PLoS One

Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14

(2010) W. R. Luebben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

(2009) Friederike Vollmuth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

(2009) Jeanne Morinière et al.   NATURE

The Euchromatic and Heterochromatic Landscapes Are Shaped by Antagonizing Effects of Transcription on H2A.Z Deposition

(2009) Sara Hardy et al.   PLoS Genetics

The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription

(2008) Gary LeRoy et al.   MOLECULAR CELL

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

(2008) Lei Zeng et al.   STRUCTURE